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Risk of malignancy in renal biopsy: A review.

Cancer Cytopathol

March 2024

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.

The risks of malignancy for cytologic categories in renal biopsy specimens differ from the risks in most other sites. There are obvious areas in which cytopathologists can do better at classifying these cases, and the routine use of immunohistochemistry and core-needle biopsy may improve the accuracy of the classification of these specimens.

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Article Synopsis
  • An increasing number of renal cell carcinoma (RCC) cases require additional studies for accurate diagnosis, although most fine needle aspirates do not.
  • Key stains like cytokeratin 7 and CD117 help differentiate between different RCC types, while other stains such as CD68 and HMB45 aid in distinguishing RCC from other conditions and recognizing certain subtypes.
  • While many RCC diagnoses can be made based on morphology alone, using immunohistochemical and molecular techniques enhances subtyping and accuracy.
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Introduction: False-negative thyroid fine-needle aspirates (FNA) are not well characterized.

Methods: We correlated the results of all thyroid aspirations from 1997 to 2016 with histologic follow-up.

Results: There were 13,733 aspirates, 2,112 (15.

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Context: High-grade urothelial carcinoma (UC) cells have many appearances on urine cytology, but according to The Paris System, they can be easily distinguished from umbrella cells.

Objective: We aimed to define the incidence and appearance of high-grade UC cells that resemble umbrella cells in Cytospin preparations on urine cytology.

Results: Cytospin preparations from 331 cases with biopsy follow-up (230 benign/low-grade and 101 malignant [22 carcinoma in situ, 52 papillary, 19 invasive UC, 8 other] cases) were reviewed.

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