Bioactive Functionalized Chitosan Thermo-Responsive Hydrogels as Promising Platforms for Therapeutic, Regenerative Oral, and Maxillofacial Applications.

Due to their superior physicochemical features, chitosan thermosensitive hydrogels are multipurpose platforms that are frequently used in the biomedical industry. Many investigations have been conducted recently to modify their pore dimensions, expansion, biodegradability, stimulus-reaction characteristics, and other characteristics in order to better tailor them to the complex craniofacial tissues. They have been the focus of various studies that have attempted to load biological cargos for therapeutic and regenerative uses in the oro-facial tissues.

Preterm Births Attributable to Criteria Air Pollutant Exposure in Bangladesh During 2015-2019.

Criteria air pollutant exposure impacts human health through various pathways. Preterm birth (PTB) is one of the major adverse birth outcomes (ABO) associated with such exposure. Although numerous global and regional studies have been conducted on this issue, few have recently investigated the impact of major criteria air pollutant exposure on PTBs in Bangladesh, one of the world's most polluted countries with the highest relative PTB rate.

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies.

Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of a wide range of brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) cause neuroinflammation, alter brain function, and accelerate disease development. Despite progress in understanding these pathways, effective medicines targeting brain inflammation are still limited.

Exosomal Liquid Biopsy in Prostate Cancer: A Systematic Review of Biomarkers for Diagnosis, Prognosis, and Treatment Response.

Prostate cancer, a leading cause of cancer-related mortality among men, often presents challenges in accurate diagnosis and effective monitoring. This systematic review explores the potential of exosomal biomolecules as noninvasive biomarkers for the diagnosis, prognosis, and treatment response of prostate cancer. A thorough systematic literature search through online public databases (Medline via PubMed, Scopus, and Web of science) using structured search terms and screening using predefined eligibility criteria resulted in 137 studies that we analyzed in this systematic review.

Restoration of Genetic Code in Macular Mouse Fibroblasts via APOBEC1-Mediated RNA Editing.

RNA editing is a significant mechanism underlying genetic variation and protein molecule alteration; C-to-U RNA editing, specifically, is important in the regulation of mammalian genetic diversity. The ability to define and limit accesses of enzymatic machinery to avoid the modification of unintended targets is key to the success of RNA editing. Identification of the core component of the apoB RNA editing holoenzyme, APOBEC, and investigation into new candidate genes encoding other elements of the complex could reveal further details regarding APOBEC-mediated mRNA editing.

Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings.

Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming's warning about the misuse of antibiotics leading to resistant microbes. With a dwindling arsenal of effective antibiotics, it is imperative to concentrate on alternative antimicrobial strategies. Previous studies have not comprehensively discussed the advantages and limitations of various strategies, including bacteriophage therapy, probiotics, immunotherapies, photodynamic therapy, essential oils, nanoparticles and antimicrobial peptides (AMPs) within a single review.

Chia () Seed Oil Modulates the Haemato-Immunological Response, Antioxidative Status and Cytokine Gene Expression of Tropical Freshwater Teleost, .

The present investigation attempts to evaluate the impact of the dietary inclusion of chia () seed oil (CSO) on the indices of haemato-immunology, metabolic enzymes, and expression of immune-responsive cytokine genes in (rohu) fingerlings. The responses were observed in a 60-day feeding trial, set up with a total of 180 rohu fingerlings (19.74 ± 0.

Plant secondary metabolites against biotic stresses for sustainable crop protection.

Sustainable agriculture practices are indispensable for achieving a hunger-free world, especially as the global population continues to expand. Biotic stresses, such as pathogens, insects, and pests, severely threaten global food security and crop productivity. Traditional chemical pesticides, while effective, can lead to environmental degradation and increase pest resistance over time.

Associations between weather extremes and faecal contamination along pathogen transmission pathways in rural Bangladeshi households: a prospective observational study.

Background: Weather extremes are predicted to influence pathogen exposure but their effects on specific faecal-oral transmission pathways are not well investigated. We evaluated associations between extreme rain and temperature during different antecedent periods (0-14 days) and Escherichia coli along eight faecal-oral pathways in rural Bangladeshi households.

Methods: We used data from the WASH Benefits Bangladesh cluster-randomised controlled trial (NCT01590095).

Effectiveness of artificially planted mangroves on remediation of metals released from ship-breaking activities.

The pervasive and escalating issue of toxic metal pollution has gathered global attention, necessitating the exploration of innovative ecological strategies like phytoremediation. This study explored the extent of potentially toxic metal contamination status and the effectiveness of three planted mangrove species (Avicennia marina, Bruguiera gymnorhiza,and Excoecaria agallocha) in phytoremediation efforts to reduce pollution level. The results indicated that the mean concentrations of elements in the sediment of the area followed a descending sequence: Fe (27,136.

Exploring the dynamics of SARS-CoV-2 and HIV Co-infection: Mutation risks, therapeutic efficacy, and future variant prevention.

High mutation rates in SARS-CoV-2, particularly among immunocompromised patients living with HIV, continue to complicate the current COVID-19 pandemic. The threshold for severe COVID-19 and a greater risk of mortality have increased in many immunocompromised individuals due to a weakened immune system. Low CD4+ T-cell counts in people living with both HIV and COVID-19 lead to prolonged disease duration and, therefore, an increased likelihood of viral infection with SARS-CoV-2 mutations in such individuals.

Genome-wide identification and characterization of cation-proton antiporter (CPA) gene family in rice (Oryza sativa L.) and their expression profiles in response to phytohormones.

The cation-proton antiporter (CPA) superfamily plays pivotal roles in regulating cellular ion and pH homeostasis in plants. To date, the regulatory functions of CPA family members in rice (Oryza sativa L.) have not been elucidated.

Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae.

Rice blast, caused by Magnaporthe oryzae, is one of the most destructive fungal diseases in rice, resulting in major economic losses worldwide. Genetic and genomic studies have identified key genes and proteins, such as AvrPik variants and MAX proteins, that are crucial for the pathogen's virulence. These effector proteins interact with specific alleles of the Pik gene family on rice chromosome 11, modulating the host's immune response.

A Review of Potentially Toxic Elements in Sediment, Water, and Aquatic Species from the River Ecosystems.

There is concern over potential toxic elements (PTEs) impacting river ecosystems due to human and industrial activities. The river's water, sediment, and aquatic life are all severely affected by the release of chemical and urban waste. PTE concentrations in sediment, water, and aquatic species from river ecosystems are reported in this review.

Examining ozone effects on the tropical C crop .

Ozone (O), a major air pollutant, can negatively impact plant growth and yield. While O impacts have been widely documented in crops such as wheat and soybean, few studies have looked at the effects of O on sorghum, a C plant and the fifth most important cereal crop worldwide. We exposed grain sorghum ( cv.

Smartphone image dataset for radish plant leaf disease classification from Bangladesh.

Radishes, which are common root vegetables, are rich in vitamins and minerals, and contain low calories. This vegetable is known for its rapid growth. Nevertheless, the variety of leaf diseases where leaves get affected by various bacterial and fungal diseases can hinder the healthy growth of radish.

Optimizing CsCuBiBr double halide perovskite for solar applications: the role of electron transport layers in SCAPS-1D simulations.

Perovskite solar cells are commonly employed in photovoltaic systems because of their special characteristics. Perovskite solar cells remain efficient, but lead-based absorbers are dangerous, restricting their manufacture. Therefore, studies in the field of perovskite materials are now focusing on investigating lead-free perovskites.

A novel hybrid ViT-LSTM model with explainable AI for brain stroke detection and classification in CT images: A case study of Rajshahi region.

Computed tomography (CT) scans play a key role in the diagnosis of stroke, a leading cause of morbidity and mortality worldwide. However, interpreting these scans is often challenging, necessitating automated solutions for timely and accurate diagnosis. This research proposed a novel hybrid model that integrates a Vision Transformer (ViT) and a Long Short Term Memory (LSTM) to accurately detect and classify stroke characteristics using CT images.

ELW-CNN: An extremely lightweight convolutional neural network for enhancing interoperability in colon and lung cancer identification using explainable AI.

Cancer is a condition in which cells in the body grow uncontrollably, often forming tumours and potentially spreading to various areas of the body. Cancer is a hazardous medical case in medical history analysis. Every year, many people die of cancer at an early stage.

Sensitivity analysis on natural convective trapezoidal cavity containing hybrid nanofluid with magnetic effect: Numerical and statistical approach.

The numerical analysis examines the attributes of magnetohydrodynamic natural convection in a closed cavity including a circular hollow. Because mono and hybrid nanofluids have many applications in thermal engineering and manufacturing, hybrid nanofluids are utilized as the substance within the entire domain. The investigation centers on a closed, trapezoidal-shaped hollow with a heated surface ring.

E-waste recycling in an optimized way for copper recovery by leaching and a case study on E-waste generation and management in Dhaka city.

The widespread adoption of electronic devices has enhanced living standards but has also led to a surge in electronic waste (e-waste), creating serious environmental and health challenges. Although various methods exist to recover valuable metals from e-waste, each has notable drawbacks. Among these, chemical leaching with aqua regia is widely used but is both highly corrosive and hazardous.

Cohort profile: the BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) cohort study.

Purpose: Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases (NCDs) in recent decades. There is, however, limited evidence about multidimensional determinants of NCDs in this population. The BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) study is a household-based prospective cohort study established to investigate biological, behavioural, environmental and broader determinants of NCDs.

Prospective role of lupeol from Pterocarpus santalinus leaf against diabetes: An in vitro, in silico, and in vivo investigation.

Diabetes mellitus (DM) can be treated with various medications. However, individuals in underdeveloped countries may face challenges in using these treatments due to side effects and high costs. Anti-diabetic medications can inhibit enzymes, such as α-amylase, which is responsible for breaking down carbohydrates.

Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups.

The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). All participants completed the SWLS under largely uniform conditions.