Genome-wide analysis of TCP family genes and their constitutive expression pattern analysis in the melon (Cucumis melo).

Background: TCP proteins are plant-specific transcription factors that play essential roles in various developmental processes, including leaf morphogenesis and senescence, flowering, lateral branching, hormone crosstalk, and stress responses. However, a comprehensive analysis of genome-wide TCP genes and their expression patterns in melon is yet to be done.

Objective: The present study aims to identify and analyze the TCP genes in the melon genome and understand their putative functions.

Identification of potential biomarkers for 2022 Mpox virus infection: a transcriptomic network analysis and machine learning approach.

Monkeypox virus (MPXV), a zoonotic pathogen, re-emerged in 2022 with the Clade IIb variant, raising global health concerns due to its unprecedented spread in non-endemic regions. Recent studies have shown that Clade IIb (2022 MPXV) is marked by unique genomic mutations and epidemiological behaviors, suggesting variations in host-virus interactions. This study aimed to identify the differentially expressed genes (DEGs) induced by the 2022 MPXV infection through comprehensive bioinformatics analyses of microarray and RNA-Seq datasets from post-infected cell types with different MPXV clades.

How climate change is shaping young people's health: a participatory, youth co-led study from Bangladesh, Guatemala and Nigeria.

Introduction: Climate change is shaping adolescent and young people's (AYP) transitions to adulthood with significant and often compounding effects on their physical and mental health. The climate crisis is an intergenerational inequity, with the current generation of young people exposed to more climate events over their lifetime than any previous one. Despite this injustice, research and policy to date lacks AYP's perspectives and active engagement.

A novel hybrid ViT-LSTM model with explainable AI for brain stroke detection and classification in CT images: A case study of Rajshahi region.

Computed tomography (CT) scans play a key role in the diagnosis of stroke, a leading cause of morbidity and mortality worldwide. However, interpreting these scans is often challenging, necessitating automated solutions for timely and accurate diagnosis. This research proposed a novel hybrid model that integrates a Vision Transformer (ViT) and a Long Short Term Memory (LSTM) to accurately detect and classify stroke characteristics using CT images.

An insight into the genome-wide analysis of bacterial defense mechanisms in a uropathogenic Morganella morganii isolate from Bangladesh.

The gram-negative, facultative anaerobic bacterium Morganella morganii is linked to a number of illnesses, including nosocomial infections and urinary tract infections (UTIs). A clinical isolate from a UTI patient in Bangladesh was subjected to high-throughput whole genome sequencing and extensive bioinformatics analysis in order to gather knowledge about the genomic basis of bacterial defenses and pathogenicity in M. morganii.

Consolidated Newborn Bloodspot Screening Efforts in Developing Countries in the Asia Pacific-2024.

Approximately half of all births globally occur in the Asia Pacific Region. Concerted efforts to support local activities aimed at developing national newborn screening (NBS) have been ongoing for almost 30 years, first by the International Atomic Energy Agency (IAEA) and then through volunteer efforts. Sustainable newborn bloodspot screening (NBS) continues to be initiated and develop in many of the countries with developing economies in the region.

Determinants of physical function, as measured using PROMIS PF-10a, in patients with rheumatoid arthritis: results from the international COVID-19 Vaccination in Autoimmune Diseases (COVAD) study.

Objectives: Physical function in RA is largely influenced by multiple clinical factors, however, there is a growing body of evidence that psychological state and other comorbidities also play an essential role. Using data obtained in the COVID-19 Vaccination in Autoimmune Diseases study, an international self-reported e-survey, we aimed to explore the predictive ability of sociodemographic and clinical variables on Patient-Reported Outcomes Measurement Information System Physical Function Short Form 10a (PROMIS PF-10a) in RA and to investigate variation in disease activity and functional outcomes based on country-level socio-economic parameters.

Methods: Patient demographics, disease characteristics including current symptom status, functional status and treatment variables, as well as income level of the country of residence, were extracted from survey responses.

Therapeutic Approaches to Tackle the Challenge of Depression That Is Resistant to Treatment-A Narrative Review.

Background And Aims: The lack of therapeutic response characterizes treatment-resistant depression despite undergoing at least two adequate monotherapy trials with medications from distinct pharmacologic classes. The inability to attain remission in patients diagnosed with major depressive disorder (MDD) is a significant issue of concern within public health. Therefore, the management of treatment-resistant depression (TRD) poses significant obstacles for both patients and healthcare professionals.

The Significant Effects of Threshold Selection for Advancing Nitrogen Use Efficiency in Whole Genome of Bread Wheat.

Currently in wheat breeding, genome wide association studies (GWAS) have successfully revealed the genetic basis of complex traits such as nitrogen use efficiency (NUE) and its biological processes. In the GWAS model, thresholding is common strategy to indicate deviation of expected range of -(s), and it can be used to find the distribution of true positive associations under or over of test statistics. Therefore, the threshold plays a critical role to identify reliable and significant associations in wide genome, while the proportion of false positive results is relatively low.

Evaluation of the Clinicopathological Features Associated With Malignancy of Phyllodes Tumor of the Breast.

Objective: Phyllodes tumor (PT) is a variant of fibroepithelial proliferations of the breast, histologically demonstrating a leaf-like pattern. The WHO has categorized PTs as benign, borderline, or malignant based on their histological characteristics. The objective of this paper is to assess the clinicopathological factors with malignancy in PT of the breast.

ELW-CNN: An extremely lightweight convolutional neural network for enhancing interoperability in colon and lung cancer identification using explainable AI.

Cancer is a condition in which cells in the body grow uncontrollably, often forming tumours and potentially spreading to various areas of the body. Cancer is a hazardous medical case in medical history analysis. Every year, many people die of cancer at an early stage.

LipBengal: Pioneering Bengali lip-reading dataset for pronunciation mapping through lip gestures.

The dataset represents a significant advancement in Bengali lip-reading and visual speech recognition research, poised to drive future applications and technological progress. Despite Bengali's global status as the seventh most spoken language with approximately 265 million speakers, linguistically rich and widely spoken languages like Bengali have been largely overlooked by the research community. fills this gap by offering a pioneering dataset tailored for Bengali lip-reading, comprising visual data from 150 speakers across 54 classes, encompassing Bengali phonemes, alphabets, and symbols.

Investigating the impact of oligo-chitosan on the growth dynamics and yield traits of L. 'BRRI dhan29' under subtropical conditions.

Reducing the harmful chemical use along with obtaining potential yield in field is a worth exploring practice in rice cultivation. To mitigate the prevailing yield gap, the current study was designed to evaluate the effect of chitosan in improving growth, yield contributing characters and yield of rice. The experiment comprised eight different treatments control (no fertilizer and Chitosan) (T), conventional method (with fertilizers) (T), conventional method with foliar spray of 100 ppm chitosan solution (T), conventional method with foliar spray of 300 ppm chitosan solution (T), conventional method with foliar spray of 500 ppm chitosan solution (T), only foliar spray of 100 ppm chitosan solution (T), only foliar spray of 300 ppm chitosan solution (T), and only foliar spray of 500 ppm chitosan solution (T).

Clinical efficacy of electrosurgery and steel scalpel surgery for umbilical herniorrhaphy in bovine calves: A comparative analysis.

Electrosurgery (ES) offers a promising alternative to conventional steel scalpel surgery (SSS), providing superior hemorrhage control and efficient tissue dissection with minimal invasiveness. Given the limited literature, this study aims to compare the clinical efficacy of ES with that of SSS in bovine umbilical herniorrhaphy. Fourteen crossbred male calves with reducible umbilical hernias, aged less than one month and weighing 25-47 kg, were randomly assigned to two experimental groups: group A (ES) and group B (SSS), each containing seven calves.

Sensitivity analysis on natural convective trapezoidal cavity containing hybrid nanofluid with magnetic effect: Numerical and statistical approach.

The numerical analysis examines the attributes of magnetohydrodynamic natural convection in a closed cavity including a circular hollow. Because mono and hybrid nanofluids have many applications in thermal engineering and manufacturing, hybrid nanofluids are utilized as the substance within the entire domain. The investigation centers on a closed, trapezoidal-shaped hollow with a heated surface ring.

E-waste recycling in an optimized way for copper recovery by leaching and a case study on E-waste generation and management in Dhaka city.

The widespread adoption of electronic devices has enhanced living standards but has also led to a surge in electronic waste (e-waste), creating serious environmental and health challenges. Although various methods exist to recover valuable metals from e-waste, each has notable drawbacks. Among these, chemical leaching with aqua regia is widely used but is both highly corrosive and hazardous.

Continental Preferences in Reconstruction of Pharyngolaryngectomy Defects: A Multi-National Survey.

Objectives: Reconstruction of total pharyngolaryngectomy defects may restore pharyngeal function and enable tracheoesophageal speech after resection of locoregionally advanced malignancy. Little remains known about variations in the practices and preferences of surgeons across differing global regions.

Methods: A survey was sent to reconstructive head and neck surgeons across three continents with responses analyzed to evaluate trends.

Exploring the Involvement of New Members of the Interleukin Family in Cardiovascular Disease.

Cardiovascular diseases remain a significant reason for illness and death globally. Although certain interleukins have been extensively researched about cardiovascular disease (CVD), new findings have identified unique members of the interleukin family that could potentially play a role in cardiovascular well-being and ailments. This review discusses the current understanding of the role of these recently identified interleukins, such as IL-27, IL-31, IL-32, IL-33, and the IL-28 group (IL-28A, IL-28B, IL-29), in the development of cardiovascular diseases.

The proper application of logistic regression model in complex survey data: a systematic review.

Background: Logistic regression is a useful statistical technique commonly used in many fields like healthcare, marketing, or finance to generate insights from binary outcomes (e.g., sick vs.

GCL_FCS30: a global coastline dataset with 30-m resolution and a fine classification system from 2010 to 2020.

The coastline reflects coastal environmental processes and dynamic changes, serving as a fundamental parameter for coast. Although several global coastline datasets have been developed, they mainly focus on coastal morphology, the typology of coastlines are still lacking. We produced a Global CoastLine Dataset (GCL_FCS30) with a detailed classification system.

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection.

Background: Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are complex and challenging due to their intricate pathophysiology and limited treatment options.

Methods: This review systematically sourced articles related to neurodegenerative diseases, neurodegeneration, quercetin, and clinical studies from primary medical databases, including Scopus, PubMed, and Web of Science.

Results: Recent studies have included quercetin to impact the cellular and molecular pathways involved in neurodegeneration.

Cohort profile: the BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) cohort study.

Purpose: Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases (NCDs) in recent decades. There is, however, limited evidence about multidimensional determinants of NCDs in this population. The BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) study is a household-based prospective cohort study established to investigate biological, behavioural, environmental and broader determinants of NCDs.

Europe's extra-territorial mineral trade and clean energy metamorphosis in a landscape of multifaceted risks.

Despite modest reserves of energy transition minerals (ETMs) like copper, nickel, and aluminium, European nations largely depend on imports, a dynamic often marred by financial uncertainties, price volatility, and geopolitical tensions. The purpose of this study is to investigate the response of extra-territorial ETM imports to the clean energy objectives of 24 European nations, taking into account financial stress, mineral price volatility, and geopolitical instability. We analyse monthly data from January 2005 to October 2022, using the quantiles via moments (QvM) and the linear models multiway fixed effects (LMFE) approaches to account for heterogeneity, spatial dependence, heteroscedasticity, and endogeneity in the data.

Prospective role of lupeol from Pterocarpus santalinus leaf against diabetes: An in vitro, in silico, and in vivo investigation.

Diabetes mellitus (DM) can be treated with various medications. However, individuals in underdeveloped countries may face challenges in using these treatments due to side effects and high costs. Anti-diabetic medications can inhibit enzymes, such as α-amylase, which is responsible for breaking down carbohydrates.