Moderate sedation induced by general anaesthetics disrupts audio-spatial feature binding with sustained P3 components in healthy humans.

Feature binding is considered to be the basis for conscious stimulus perception, while anaesthetics exert a gradient effect on the loss of consciousness (LOC). By integrating these two streams of research, the present study assessed the effect of two anaesthetic agents (i.e.

Role of neutrophil to lymphocyte ratio as a prognostic indicator for epithelial ovarian cancer.

Objective: To determine whether level of preoperative peripheral blood neutrophil to lymphocyte ratio (NLR) was a prognostic indicator for epithelial ovarian cancer (EOC) patient. The present study further aimed to evaluate the impact of the change of preoperative/postoperative NLR on the survival.

Material And Method: Medical records of the patients undergoing an operation for EOC in Vajira Hospital between January 1, 2004 and December 31, 2009 were reviewed.

Clinicopathological features including hormonal receptor expression and survival in young endometrial cancer patients: a case control study.

Objective: To compare clinicopathological features, including hormonal receptor expression and survival, in young Thai endometrial carcinoma (EMC) patients with older patients.

Methods: Young EMC patients aged ≤45 years, treated in the institution from 1992 to 2008, were identified as cases. Controls included EMC patients aged >45 years who had an operation on the nearest dates to the cases.

Prevalence of hyperuricemia in Bangkok population.

To investigate the prevalence of hyperuricemia in general Thai population and to evaluate its association with metabolic syndrome. A total of 1,945 subjects who sought for routine annual health checkup in our hospital from 1 October 2009 to 31 March 2010 were enrolled into the study. Inclusion criteria were healthy individuals, aged ≥35 years old, and lived in Bangkok for over 10 years.

Endometrial cancer in Thai women: clinico-pathological presentation and survival.

Objective: To assess the characteristic features, treatment, survival, and prognostic factors of Thai endometrial cancer (EMC) patients.

Methods: Clinico-pathological data of EMC patients who were treated in the institution from 1992 to 2008 were collected. Survival rates and prognostic factors were studied.

Interval debulking surgery for advanced epithelial ovarian cancer.

Background: Interval debulking surgery (IDS), following induction or neoadjuvant chemotherapy, may have a possible role in treating advanced epithelial ovarian cancer (stage III to IV) where primary debulking surgery is not an option.

Objectives: To assess the effectiveness and complications of IDS for patients with advanced stage epithelial ovarian cancer.

Search Strategy: We searched the Cochrane Gynaecological Cancer Group's Specialised Register to July 2009, the Cochrane Central Register of Controlled Trials (CENTRAL) Issue 2, 2009, MEDLINE from January 1966 to June week 4 2009, and EMBASE from January 1966 to week 27 2009.

Expression of ER, PR, and Her-2/neu in endometrial cancer: a clinicopathological study.

Objective: To determine any association between expression of estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu and clinicopathological features, including survival, of endometrial carcinoma (EMC) patients.

Methods: Samples of formalin-fixed, paraffin-embedded tissue of 108 patients with EMC treated at our institution between January 1994 and December 2007 were immunohistochemically studied.

Results: ER, PR, and Her-2/neu expression were positive in 59.

Effects of posterior cruciate ligament resection in total knee arthroplasty using computer assisted surgery.

Objective: The authors prospectively measure the effects of Posterior Cruciate Ligament (PCL) excision in Total Knee Arthroplasty (TKA) using Computer Assisted Surgery (CAS).

Material And Method: Between April 2008 and June 2008, sixteen knees of fifteen patients with varus deformity less than 20 degree and grossly intact PCL were included in this study. Using CAS and tensioning device to maintain consistent pressure, extension and flexion gap on both medial and lateral side before and after resection of PCL was recorded.

A comparison of early clinical outcome in computer assisted surgery and conventional technique in minimally invasive total knee arthroplasty.

Objective: To compare the clinical outcomes of minimally invasive total knee arthroplasty (MIS TKA) with and without computer assisted surgery (CAS).

Material And Method: From September 2007 to February 2008, 64 patients (70 knees) underwent MIS TKA were included. Clinical data such as operative time, pain score, total blood loss and Radiographic data were recorded and compared.

Anatomical landmark of descending genicular artery for minimidvastus approach of the knee.

Objective: To determine the anatomical course of descending genicular artery and to identify a safety zone for minimidvastus approach.

Material And Method: Forty-eight knees from twenty-four fresh cadavers were dissected to identify the descending genicular artery, and to measure the distance between such artery and superomedial pole of the patella as well as the entry angle of such artery to the perpendicular line of the vertical axis of the patella.

Results: The average distance between the descending genicular artery and superomedial pole of the patella was 8.

Comparison of the accuracy of quadriceps isometric exercise between using quadriceps education device (QED) and not using QED for osteoarthritic knee patients: a randomized controlled trial.

Objective: To compare the accuracy when osteoarthritic knee patients do quadriceps isometric exercise using quadriceps education device (QED) and not using QED after being instructed on the exercise program by doctors.

Material And Method: A randomized controlled study was conducted. Sixty patients were divided into 2 groups, QED group (patients using QED) and non-QED group (patients not using QED).

A comparison of blood loss in minimally invasive surgery with and without electromagnetic computer navigation in total knee arthroplasty.

Objective: To compare the blood loss after minimally invasive surgery total knee arthroplasty (MIS-TKA) between the procedures performed with and without electromagnetic computer navigation.

Material And Method: Eighty patients were recruited for a cohort study of the minimally invasive surgery total knee arthroplasty (MIS-TKA) for the treatment of osteoarthritis. They were divided into two groups, 40 patients had a computer-assisted surgery procedure for the minimally invasive surgery total knee arthroplasty (CAS-MIS-TKA) and the other 40 patients had a conventional procedure for the minimally invasive surgery total knee arthroplasty (MIS-TKA).

Liqui-Prep® versus conventional Papanicolaou smear to detect cervical cells abnormality by split-sample technique: a randomized double-blind controlled trial.

To assess the diagnostic performances of LiquiPrep® (LP) to detect cervical cellular abnormality in comparison to Papanicolaou (Pap) smear in 194 women with abnormal cervical cytology who were scheduled for colposcopy at the institution between January 2008 and November 2008. The women were randomized to undergo a repeated cervical cytologic evaluation by Pap smear followed by LP, or the two methods in alternating order. The pathologist was blinded to previous cytologic diagnosis and the pair of slides assigned for each woman.

Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes.

Objective: To evaluate clinico-pathological features, treatment, survival, and prognostic factors of patients with malignant ovarian germ cell tumors.

Design: Descriptive study.

Setting: Bangkok Metropolitan Administration Medical College and Vajira Hospital and Prince of Songkla University.

Oral etoposide for refractory or recurrent epithelial ovarian cancer.

Objective: To study the response rate (RR), toxicity, progression-free survival (PFS), and overall survival (OS) of the patients with recurrent or refractory epithelial ovarian cancer (EOC), who had oral etoposide at dosage of 75 mg/day.

Material And Method: Patients with recurrent or refractory EOC who were treated with oral etoposide between January 1998 and December 2007 were identified from the Archive of the Gynecologic Oncology Unit of the institution. Clinical and pathological data were reviewed.

Management of endometrial cancer in Asia: consensus statement from the Asian Oncology Summit 2009.

Endometrial cancer is one of the gynaecological cancers that carries good overall prognosis because it is often detected at early stages of disease. The International Federation of Gynecology and Obstetrics replaced clinical staging with surgical staging in 1988 and updated the system in 2009. Controversies remain regarding the recommended screening protocol for women with a high risk of endometrial cancer, the role and benefit of retroperitoneal lymph-node dissection, the necessity of ovarian resection, the benefit and type of adjuvant radiation therapy, and the safety of hormone-replacement therapy after treatment.

Comparison between clinical and surgical staging for endometrial cancer in Thailand.

Objectives: To compare preoperative clinico-pathological findings and clinical staging of endometrial cancers (EMC) with postoperative surgico-pathological findings and final surgical staging.

Materials And Methods: All EMC patients who underwent surgical staging between January 1993 and December 2008 were identified from the tumor registry of the Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, of our institution. Clinico-pathological data were extracted from the patients' charts and pathological reports, including clinical stage assignments before the operation, and compared to the surgico-pathological findings.

Accuracy of fine needle aspiration cytology from breast masses in Thailand.

Objective: To evaluate the accuracy and diagnostic performance of fine needle aspiration FNA cytology in diagnoses of breast masses.

Methods: Women who had FNA diagnoses for breast masses and underwent subsequent histopathologic evaluation during January 2003-December 2006 were accessed from the archive of the Anatomical Pathology Department of our institution. Cytologic diagnoses were classified as unsatisfactory, benign, atypical probably benign, suspicious probably malignant, and malignant, and were compared to the histopathologic diagnoses obtained from core needle biopsy, excisional biopsy, or mastectomy to give an assessment of the diagnostic performance of FNA.

Treatment outcomes and prognostic factors of patients with breast cancer: a retrospective review.

Objective: To determine overall survival (OS), disease-free survival (DFS), and prognostic factors for survival in patients with invasive breast cancer treated with combined-modality therapy at BMA Medical College and Vajira Hospital.

Material And Method: The authors retrospectively analyzed the patient-tumor characteristic and treatment outcomes of 615 patients with invasive breast cancer who were treated in our radiation oncology division between 1997 and 2006. The authors used the Kaplan-Meier method to describe OS and DFS.

The ratio of 2nd and 4th digit length in autistic children.

Objective: To compare 2D:4D ratios of autistic to non-autistic children as a risk factor of autism.

Material And Method: A hospital based case-control study was conducted from March 2007 to July 2008. Demographic data and general risk factors of autism had been collected using questionnaires from case and age matched control subjects aged 18 months to 15 years.

Risk assessment for preeclampsia in women with gestational diabetes mellitus.

Aim: To develop a clinical model to assess the risk of preeclampsia in women with gestational diabetes mellitus (GDM).

Methods: We studied clinical characteristics of 813 consecutive women who had GDM between January 2003 and February 2008 at our institution. The clinical features which were significantly associated with preeclampsia by multiple logistic regression analysis were integrated into a risk model.

Expressions of estrogen and progesterone receptors in epithelial ovarian cancer: a clinicopathologic study.

Although estrogen (ER) and progesterone (PR) receptors are well recognized as important prognostic indicators of breast and endometrial cancers, their clinical significance in epithelial ovarian cancer is not clear with the limited data from only few immunohistochemical studies. The aim of this study was to evaluate the expressions of ER and PR in patients with epithelial ovarian cancer who were treated in our institution during the period 1996 to 2003. Their associations with clinicopathologic factors of age, stage, histologic subtypes, and grade and their prognostic role to survivals were also examined.

A risk score for selective screening for gestational diabetes mellitus.

Objective: To develop a risk score to predict women who are likely to have an abnormal glucose challenge test (GCT) for gestational diabetes mellitus (GDM) screening.

Study Design: A cohort of 1876 pregnant women who underwent a GCT between March 2005 and December 2005 at our institution were studied. A multivariable analysis was performed to determine the clinical features that were significantly associated with an abnormal GCT.

Interval debulking surgery for advanced epithelial ovarian cancer.

Background: Primary debulking surgery, a crucial step in the management of epithelial ovarian cancer, is not always an option in patients with advanced stage disease (stage III to IV). In some circumstances, surgery may not yield satisfactory results with residual tumour masses > 1 to 2 cm (so called suboptimal surgery). Induction or neoadjuvant chemotherapy followed by interval debulking surgery (IDS) may have an alternative role in this setting.