Anti-filarial efficacy of : unravelling the underlying mechanisms through biochemical, HRAMS proteomics and MD simulation approaches.

Traditionally, (CA) has been reported to be a potent anti-filarial, however no reports are available detailing its mechanism of action against filarial parasites. In this study, we have evaluated the anti-filarial activity of CA against lymphatic filarial parasites using biochemical, proteomics and approaches. The motility and viability of the parasites decreased significantly after treatment with CA concentrations of ≥125 μg mL.

Inkjet-printed flexible graphene paper electrode for the electrochemical determination of mercury.

Here, we report an inkjet-printed graphene paper electrode (IP-GPE) for the electrochemical analysis of mercuric ions (Hg(ii)) in industrial wastewater samples. Graphene (Gr) fabricated on a paper substrate was prepared by a facile solution-phase exfoliation method in which ethyl cellulose (EC) behaves as a stabilizing agent. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were utilized to determine the shape and multiple layers of Gr.

Enhanced mechanical properties of hBN-ZrO composites and their biological activities on : synthesis and characterization.

In this study, six compositions in the system [(h-BN)-(100 - )ZrO] (10 ≤ ≤ 90) were synthesized by a bottom up approach, , the solid-state reaction technique. XRD results showed the formation of a novel and main phase of zirconium oxynitrate ZrO(NO) and SEM exhibited mixed morphology of layered and stacked h-BN nanosheets with ZrO grains. The composite sample 10 wt% h-BN + 90 wt% ZrO (10B90Z) showed outstanding mechanical properties for different parameters, , density (3.

Insights into the interaction of potent antimicrobial chalcone triazole analogs with human serum albumin: spectroscopy and molecular docking approaches.

Mechanistic insights into the interaction of five previously chemically synthesized triazole-linked chalcone analogs (CTs) with human serum albumin (HSA) were sought using various spectroscopic techniques (UV-visible absorption, fluorescence, and circular dichroism) and molecular docking. The fluorescence quenching experiments performed at three different temperatures (288, 298 and 308 K) revealed the static mode of quenching and the binding constants ( ∼ 10) obtained indicated the strong affinity of these analogs for HSA. Furthermore, significant changes in the secondary structure of HSA in the presence of these analogs were also confirmed by far UV-CD spectroscopy.