8 results match your criteria: "Baltimore (M.K.E.); and Brigham and Women's Hospital[Affiliation]"
Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults.
Neurology
May 2022
From the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Background And Objectives: Serum antioxidant vitamins and carotenoids may protect against neurodegeneration with age. We examined associations of these nutritional biomarkers with incident all-cause and Alzheimer disease (AD) dementia among US middle-aged and older adults.
Methods: Using data from the third National Health and Nutrition Examination Surveys (1988-1994), linked with Centers for Medicare & Medicaid follow-up data, we tested associations and interactions of serum vitamins A, C, and E and total and individual serum carotenoids and interactions with incident AD and all-cause dementia.
Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.
Stroke
August 2020
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (M.F.).
Background And Purpose: Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans.
Methods: The COMPASS (Consortium of Minority Population Genome-Wide Association Studies of Stroke) has conducted a genome-wide association meta-analysis of stroke in >22 000 individuals of African ancestry (3734 cases, 18 317 controls) from 13 cohorts.
Diagnosing and Treating Systemic Racism.
N Engl J Med
July 2020
From the National Institute on Aging, Baltimore (M.K.E.); and Brigham and Women's Hospital, Boston (L.R.).
Distributions of Subclinical Cardiovascular Disease in a Socioeconomically and Racially Diverse Sample.
Stroke
April 2017
From the Department of Psychology, University of Maryland, Baltimore County (C.R.W., S.R.W.); Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, NIH (C.R.W., M.K.E., A.B.Z.); Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine (S.R.W.); and Geriatric Research Education and Clinical Center, Baltimore VAMC, MD (S.R.W.).
Background And Purpose: Differential subgroup vulnerability to subclinical cardiovascular disease is likely, and yet few, if any, studies have addressed interactive relations of age, sex, race, and socioeconomic status (SES) to these conditions to examine nuances of known health disparities. We examined distributions of carotid atherosclerosis and arterial stiffness in a socioeconomically diverse, biracial, urban sample.
Methods: Participants (n=2270) in the population-based HANDLS study (Healthy Aging in Neighborhoods of Diversity Across the Life Span; 30-64 years old, 44% men, 57% African American, 39% with household income <125% federal poverty threshold) underwent carotid intimal medial thickness (IMT) and pulse wave velocity assessment.
Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.
Stroke
August 2015
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (C.L.C., C.K., A.R.); Center for Health Disparities, East Carolina University, Greenville, NC (K.L.K.); Baltimore Veterans Administration Medical Center, MD (Y.-C.C., S.J.K.); University of Maryland School of Medicine, Baltimore (Y.-C.C., S.J.K., B.D.M.); Mayo Clinic Florida, Jacksonville, FL (J.F.M.); Public Health Sciences, University of Virginia, Charlottesville (W.-M.C., S.S.R., M.M.S., B.B.W.); National Institute of Aging, NIH, Bethesda, MD (M.N., S.T., A.B.Z., M.K.E.); University of Washington, Seattle (J.C.B., W.T.L., B.M.P., A.R.); Wake Forest University, Winston-Salem, NC (C.D.L., Y.L.); Division of Cerebrovascular Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (R.G.); Department of Neurology, University of Mississippi Medical Center, Jackson (T.H.M.); Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson (E.S.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (D.W.); Department of Psychiatry, University of California, San Francisco (K.Y.); Institute for Stroke and Dementia Research, Munich Cluster for Systems Neurology (Synergy), Klinikum der Universität München, Ludwig-Maximilians-Universität; Munich, Germany (M.D., R.M.); Group Health Research Unit, Group Health Cooperative, Seattle, WA (B.M.P.); and Center for Human Genetics, University of Texas, Houston (M.F.).
Background And Purpose: The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African Americans, despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population Genome-Wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations.
Methods: Using METAL, we conducted meta-analyses of GWAS in 14 746 African Americans (1365 ischemic and 1592 total stroke cases) from COMPASS, and tested genetic variants with P<10(-6) for validation in METASTROKE, a consortium of ischemic stroke genetic studies in European-ancestry populations.
Dietary antioxidant intake and its association with cognitive function in an ethnically diverse sample of US adults.
Psychosom Med
January 2015
From the National Institute on Aging (M.A.B., M.H.K.-T., M.K.E., A.B.Z.), NIA/NIH/IRP, Baltimore, Maryland; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark, Delaware; Graduate Program in Public Health (H.A.B.), Eastern Virginia Medical School, Norfolk, Virginia; Department of Epidemiology, Biostatistics, and Occupational Health, (J.S.K.) McGill University, Montreal, Quebec, Canada; and Statistical Information Systems (M.A.M.), MedStar Research Institute, Baltimore, Maryland.
Background: Dietary antioxidants can inhibit reactions accompanying neurodegeneration and thus prevent cognitive impairment. We describe associations of dietary antioxidants with cognitive function in a large biracial population, while testing moderation by sex, race, and age and mediation by depressive symptoms.
Methods: This was a cross-sectional analysis of 1274 adults (541 men and 733 women) aged 30 to 64 years at baseline (mean [standard deviation] = 47.
PALB2 mutations and breast-cancer risk.
N Engl J Med
August 2014
From the Health Disparities Research Section, Laboratory of Epidemiology and Populations Sciences, National Institute on Aging, National Institutes of Health, Baltimore (M.K.E.).
Vitamin D-binding protein and vitamin D status of black Americans and white Americans.
N Engl J Med
November 2013
From the Department of Medicine, Brigham and Women's Hospital (C.E.P.), Division of Nephrology, Massachusetts General Hospital (J.W., H.T., I.B., R.T.), Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (A.H.B.), Division of Nephrology, Beth Israel Deaconess Medical Center (D.Z., S.A.K.), and Howard Hughes Medical Institute (D.Z., S.A.K.) - all in Boston; the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore (M.K.E., A.B.Z.); the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.N.); and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco (N.R.P.).
Background: Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency.
Methods: In the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort of blacks and whites (2085 participants), we measured levels of total 25-hydroxyvitamin D, vitamin D-binding protein, and parathyroid hormone as well as bone mineral density (BMD).