293 results match your criteria: "Balanitis Xerotica Obliterans"
Current Potential Outcomes of Buccal Mucosal Graft Anterior Urethroplasty for Male Urethral Stricture: A Single-Centre Study in Nepal.
Cureus
September 2024
Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, NPL.
Article Synopsis
- This study analyzes the effectiveness and complications of Buccal Mucosal Graft (BMG) urethroplasty for treating anterior urethral strictures in 130 patients over a 48-month period.
- The results show an 84.6% success rate, with recurrence occurring in 15.4% of cases and complications such as erectile dysfunction (11%) and post-micturition dribbling (14%) reported.
- Key factors predicting stricture recurrence include age, stricture length, and anatomical location, with penile location being the strongest predictor.
Down Syndrome in Children: A Primary Immunodeficiency with Immune Dysregulation.
Children (Basel)
October 2024
Student Scientific Society, English Division, Poznań University of Medical Sciences, 61-701 Poznań, Poland.
The multisystemic features of Down syndrome (DS) in children are accompanied by immunodeficiency, making them susceptible to infections and immune dysregulation with autoimmune, allergic, inflammatory, and hematological complications. This study was aimed at a better understanding of the abnormalities within the B and T cell compartments and their correlations with clinical immunophenotypes. Medical records of 35 DS children were retrospectively reviewed, referring to clinical symptomatology including history of infections, immune dysregulation disorders, and humoral and cellular immune response.
View Article and Find Full Text PDFArticle Synopsis
- * A case study involved a 32-year-old male who received Ayurvedic Uttar Basti therapy over nine months, which includes the administration of medicated oil through the urethra.
- * The treatment led to significant improvements in urinary flow metrics, including a 25% increase in Maximum Flow rate and a 143% increase in Average Flow rate, also allowing the patient to avoid further surgery.
Meatotomy and meatoplasty on meatal stenosis due to balanitis xerotica obliterans.
Urol Case Rep
September 2024
Working Team of Research, Sulianti Saroso Hospital, Jakarta, Indonesia.
Balanitis xerotica obliterans (BXO) is a chronic inflammatory disease affecting the male genitalia that is mostly underdiagnosed and undertreatment. We presented a 40-year-old man with meatal stenosis and an inability to urinate. Discoloration at the tip of the penis was found, and he said it got wider as he grew up.
View Article and Find Full Text PDFSelective Histopathology Examination for Circumcision Specimens: A Retrospective Observational Study.
Cureus
August 2024
Urology, Royal Bournemouth Hospital, Bournemouth, GBR.
Article Synopsis
- Circumcision is commonly performed for various reasons, and this study aimed to assess if routine histopathological examinations of foreskin specimens are necessary after adult circumcision.
- A retrospective analysis of 334 male patients showed that only 2.7% had preoperative clinical suspicions, and among them, only 0.9% were found to have malignancy.
- The majority of patients (97.3%) with no suspicious features preoperatively showed no signs of malignancy, suggesting routine histopathological examination may not be required for every case.
Delay in diagnosis and undertreatment of lichen sclerosus in pediatric male patients: A retrospective case series.
J Am Acad Dermatol
December 2024
Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address:
Utilizing reflectance confocal microscopy for surveillance of neoplastic changes in penile lichen sclerosus: A report of two cases.
JAAD Case Rep
August 2024
Clinical and MOH's Services, Upstate Dermatology, Castleton on Hudson, New York.
Treatment algorithm for the comprehensive management of severe lichen sclerosus in boys based on the pathophysiology of the disease.
J Pediatr Urol
July 2024
Director of GU Reconstructive Center Mercy Health, Professor of Surgery University of Illinois College of Medicine Rockford, United States. Electronic address:
Article Synopsis
- Lichen sclerosus (LS) is a rare condition affecting about 1 in 200 boys, where mismanagement can lead to severe progression, requiring careful handling of urethral tissues.
- A study reviewed patients aged 6-10 with severe LS, analyzing treatments like topical steroids and surgeries, ultimately creating a management algorithm based on their cases.
- The findings emphasize the importance of early diagnosis and treatment, as improper management can worsen the condition, leading to difficult-to-treat complications.
Meatal Surgery at the Time of Circumcision for Lichen Sclerosus (LS/BXO) Does Not Reduce the Need for Later Meatal Intervention: A Retrospective Cohort Study.
J Pediatr Surg
September 2024
Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, L12 2AP, UK.
Article Synopsis
- The study investigates outcomes for boys who underwent circumcision to treat Lichen Sclerosus, focusing on those who had additional meatal procedures at the time of circumcision.
- A total of 382 patients were examined, revealing that a significant portion had meatal involvement and were more likely to undergo further interventions if they had a meatotomy or received postoperative steroids.
- The findings suggest that performing a meatotomy during circumcision increases the risk of needing additional meatal procedures later, indicating it may not be advisable.
Penile Carcinoma Secondary to Balanitis Xerotica Obliterans and Its Compounding Resultant Pathologies: A Case Report.
Cureus
May 2024
Pathology, Merit Health Wesley, Hattiesburg, USA.
Article Synopsis
- A 57-year-old African-American male faced urinary retention due to balanitis xerotica obliterans (BXO) and penile cancer, which complicated his situation and led to frequent hospital visits.
- *BXO is a progressive condition that causes inflammation and scarring of the male genital area, leading to various complications like urinary issues and an increased risk of cancer.
- *Treatment involved placing a Foley catheter, dilating strictures, and managing pain, emphasizing the need for ongoing monitoring and intervention to prevent further complications.
Neonatal Male Circumcision: Clearly Beneficial for Public Health or an Ethical Dilemma? A Systematic Review.
Cureus
February 2024
Urology, University of Washington, Seattle, USA.
Article Synopsis
- A systematic review of neonatal male circumcision (NMC) analyzed 61 articles and found it to be a low-risk procedure with significant immediate and long-term health benefits, rarely causing adverse effects.
- The review concludes that discouraging or denying NMC is unethical under the United Nations Convention on the Rights of the Child and is legally supported by case law.
- It emphasizes that reducing NMC rates in the U.S. could lead to an increase in adverse medical conditions, making NMC an important public health intervention.
Immunologic and nonimmunologic sclerodermal skin conditions - review.
Front Immunol
February 2024
Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica - CIM-CID), "Dunărea de Jos" University, Galaţi, Romania.
Article Synopsis
- * These lesions have been linked to autoimmune diseases (like generalized morphea and chronic graft versus host disease), tissue storage diseases, metabolic disorders, and some progeroid syndromes.
- * Accurate diagnosis is crucial for distinguishing these lesions from each other to ensure the right treatment is administered.
Clinical Classification of Urethrocutaneous Fistulas Developing after Hypospadias Repair.
Indian J Plast Surg
June 2023
Department of Burns and Plastic Surgery and Hypospadias and VVFs Clinic, Postgraduate Institute of Medical Sciences, University of Health Sciences, Rohtak, Haryana, India.
Article Synopsis
- A clinical classification system for urethrocutaneous fistulas (UCFs) was developed to help surgeons categorize different types of fistulas, choose appropriate treatments, and manage patient records effectively.
- The study analyzed data from 68 patients treated for UCFs between 2004 and 2016, classifying the fistulas into several categories (A to E) based on their characteristics and complexity, which influenced the treatment approach.
- Results showed that most patients did not experience recurrence of fistulas after treatment, supporting the utility of the classification system in guiding effective management of UCFs.
Genital and Extragenital Lichen Sclerosus et Atrophicus: A Case Series Written Using ChatGPT.
Cureus
May 2023
Department of Dermatology, Belagavi Institute of Medical Sciences, Belagavi, IND.
Article Synopsis
- Lichen sclerosus et atrophicus (LSEA) is a chronic skin condition affecting both genders, predominantly seen in postmenopausal women and can present in genital or extragenital areas.
- The study analyzed 20 LSEA patients from a South Indian teaching hospital, finding most were female, with a significant portion being postmenopausal and many experiencing associated health issues like joint pain and hypertension.
- The research highlights the need for careful diagnosis to distinguish LSEA from other skin disorders and suggests further investigation into its links with autoimmune diseases.
Lichen sclerosus: The 2023 update.
Front Med (Lausanne)
February 2023
Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Article Synopsis
- Lichen sclerosus (LS) is a poorly understood inflammatory condition primarily affecting the genital areas, mostly in postmenopausal women, but also seen in men and children; its causes are still unclear despite links to hormonal changes and autoimmune issues.
- The disease is characterized by chronic whitish patches, itching, and potential complications like genital scarring, sexual dysfunction, and an increased risk of squamous cell carcinoma; diagnosis is mostly clinical with skin biopsies performed as needed.
- Treatment typically involves potent topical corticosteroids, with some emerging alternatives like topical calcineurin inhibitors, but overall, LS has limited treatment options and requires further research to better understand its features and management.
Effectiveness and Safety of Ozone Therapy for Dermatological Disorders: A Literature Review of Clinical Trials.
Indian J Dermatol
January 2022
Faculdade de Farmácia, Departamento de Produção de Matéria-Prima, Universidade Federal do Rio Grande do Sul, Porto Alegre- RS, Brazil.
Article Synopsis
- * A review of 18 controlled clinical trials from the last decade involved 1279 patients, focusing on conditions like diabetic foot ulcers and skin burns, showing mostly positive results except for a few studies that reported the treatment's ineffectiveness.
- * While some mild side effects occurred, serious adverse effects were rare; overall, ozone therapy may serve as an alternative for difficult-to-treat skin issues, but further high-quality research is necessary to ensure its safety.
Reconstruction of the male external genitalia in diverse disease processes: Our reconstructive algorithm, techniques, and experience.
Curr Urol
September 2022
Department of Urology and Andrology, University Hospital Waterford, Waterford, Ireland.
Article Synopsis
- The study focuses on reconstructive surgery for male genital issues caused by non-cancerous diseases, assessing its psychological and functional impacts.
- A review of 14 cases from 2018 to 2020 highlighted various conditions leading to genital abnormalities and involved diverse surgical techniques tailored to each patient's needs.
- Findings suggest that reconstructive methods can significantly enhance both the appearance and function of the male genitalia affected by these medical issues.
Anterior urethral valve associated with balanitis xerotica obliterans: A rare case report.
Asian J Surg
March 2023
Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China.
Post-operative steroids in boys with histologically proven balanitis xerotica obliterans reduce the need for subsequent meatal dilatation.
J Paediatr Child Health
November 2022
Department of Paediatric Surgery, St George's Hospital, London, United Kingdom.
Article Synopsis
- - The study aimed to investigate whether the use of topical steroids after circumcision can lower the number of boys with balanitis xerotica obliterans (BXO) who need further meatal dilation procedures, regardless of the urethral meatus appearance.
- - A review of 117 pediatric patients with confirmed BXO showed that those given topical steroids had significantly lower rates of subsequent meatal dilation (only 1 out of 59 patients), compared to the overall cohort.
- - The findings suggest that topical steroids are beneficial in reducing the necessity for further meatal procedures in boys diagnosed with BXO, highlighting the importance of post-operative care in this condition.
Prevalence and sequelae of penile lichen sclerosus in males presenting for circumcision in regional Australia: a multicentre retrospective cohort study.
Transl Androl Urol
June 2022
Department of Urology, Toowoomba Hospital, Queensland, Australia.
Article Synopsis
- - The study analyzed the prevalence and consequences of lichen sclerosus (LS) in men who underwent circumcision across multiple hospitals in Australia from 2004 to 2018.
- - Out of 611 circumcised patients, 63.6% were confirmed to have LS, with a median diagnosis age of 65 years, highlighting a significant prevalence of this condition.
- - Among those with LS, 22.1% developed urethral strictures, while there were rare instances of penile squamous cell carcinoma and intraepithelial neoplasia.
Balanitis xerotica obliterans: An observational, descriptive and retrospective clinical study.
Exp Ther Med
May 2022
CMI DERMAMED Private Medical Office, 540530 Târgu Mureș, Romania.
Article Synopsis
- * A study analyzing data from 2006-2020 found 164 patients diagnosed with BXO, with a significant number (42.8%) in the 51-60 age group and most patients (75.6%) presenting at advanced disease stages, leading to severe symptoms.
- * Comorbidities like diabetes and obesity were common among patients, influencing the disease's progression, and the primary treatment involved using potent steroids, with few needing surgical intervention.
Primary care of preputial adhesions in children - a retrospective cohort study.
Malays Fam Physician
March 2022
MCh, Department of Pediatric Surgery, ESIC medical college Hospital, sanath nagar, Hyderabad.
Article Synopsis
- * A review of health records showed that 89.2% of the 65 symptomatic boys achieved complete retraction after adhesiolysis, while only 10.8% required circumcision due to persistent issues.
- * The findings suggest that preputial adhesiolysis is a safe and effective alternative to circumcision for young boys, and it should be considered a primary treatment option for this condition.
Comparison of lichen sclerosus in boys and girls: A systematic literature review of epidemiology, symptoms, genetic background, risk factors, treatment, and prognosis.
Pediatr Dermatol
May 2022
Department of Dermatology, Center of Paediatric Dermatology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
Article Synopsis
- A systematic review was conducted to compare how lichen sclerosus affects boys and girls, focusing on epidemiology, symptoms, genetics, risk factors, treatment, and prognosis.
- Out of 1780 articles reviewed, 90 met the criteria, revealing that boys and girls exhibit similar clinical characteristics but have different treatment and follow-up approaches.
- The findings suggest the need for further research, particularly on follow-up care, to enhance understanding and management of lichen sclerosus in children.