Molecular and immunohistochemical study of exon 16 and its possible role in colorectal carcinoma development.

Background: Colorectal cancer ranks second as a cause of cancer deaths. Mutations in the adenomatous polyposis coli () gene, especially in exon 16, could contribute to colorectal carcinoma development. This study explored the correlations between gene exon 16 variations/expression and colorectal carcinoma progression.