6 results match your criteria: "Bai Jerbai Wadia Children's Hospital[Affiliation]"

Case: We report a unique case of a combination of forearm fracture and traumatic radial artery pseudoaneurysm in an 8-year-old child. The fracture pattern was a Monteggia equivalent with a mid-diaphyseal ulnar fracture and a radial neck fracture with displacement of the distal radial diaphyseal fracture fragment. The pseudoaneurysm, which probably developed after vigorous manipulation by a bonesetter, thrombosed spontaneously, and the fracture was managed nonoperatively with a good outcome.

View Article and Find Full Text PDF

Objectives: Severe combined immunodeficiency (SCID) represents one of the most severe forms of Primary immunodeficiency (PID) disorders, characterized by T cell lymphopenia (TCL) and lack of cellular and humoral immune responses. However, not all patients with low T cell lymphocyte counts may have an abnormal T cell immunity and the observed TCL may be a temporary suppression resulting from transient lymphopenia secondary to severe infections. In such cases, it is necessary to estimate the severity of the observed TCL by assessing thymic capabilities.

View Article and Find Full Text PDF
Article Synopsis
  • Severe Combined Immunodeficiency (SCID) is a critical primary immunodeficiency disorder marked by weak immune response, with a study of 57 Indian patients revealing symptoms like recurrent pneumonia and failure to thrive predominantly appearing in infants under 6 months.
  • Hematopoietic Stem Cell Transplantation (HSCT) is the only effective treatment, though only four patients in the study received it, resulting in poor survival rates, and a significant 63% of patients exhibited lymphopenia.
  • Genetic analysis revealed a diverse array of mutations contributing to SCID, with 32 novel variants identified, while 14% of cases remained uncharacterized despite advanced sequencing techniques; most cases involved T
View Article and Find Full Text PDF

Congenital hyperinsulinism (HI) is characterized by profound hypoglycemia caused by inappropriate insulin secretion. HI is a heterogeneous disorder with at least two histologic lesions and several implicated genes. If HI is caused by a focal lesion, elective surgery is the treatment of choice because it leads to complete recovery without diabetes.

View Article and Find Full Text PDF

Congenital syphilis: The continuing scourge.

Indian J Sex Transm Dis AIDS

September 2015

Department of Pediatrics, Bai Jerbai Wadia Children's Hospital, Mumbai, Maharashtra, India.

Congenital syphilis is a severe, disabling infection that occurs due to the transmission of Treponema pallidum across the placenta during pregnancy or from contact with an infectious genital lesion during delivery. However, its early diagnosis is often difficult because more than half of the affected infants are asymptomatic, and the signs in symptomatic infants may be subtle and nonspecific. Although its incidence is declining, this long-forgotten disease continues to affect pregnant women, resulting in considerable perinatal morbidity and mortality.

View Article and Find Full Text PDF