Powering up targeted protein degradation through active and passive tumour-targeting strategies: Current and future scopes.

Targeted protein degradation (TPD) has emerged as a prominent and vital strategy for therapeutic intervention of cancers and other diseases. One such approach involves the exploration of proteolysis targeting chimeras (PROTACs) for the selective elimination of disease-causing proteins through the innate ubiquitin-proteasome pathway. Due to the unprecedented achievements of various PROTAC molecules in clinical trials, researchers have moved towards other physiological protein degradation approaches for the targeted degradation of abnormal proteins, including lysosome-targeting chimeras (LYTACs), autophagy-targeting chimeras (AUTACs), autophagosome-tethering compounds (ATTECs), molecular glue degraders, and other derivatives for their precise mode of action.

Congential nasolacrimal duct obstruction: investigating the role of systemic inflammation through novel biomakers.

Objective: Congenital nasolacrimal duct obstruction (CNLDO) is a common lacrimal system anomaly in newborns and infants. We aimed to evaluate the role of inflammation in the pathogenesis of persistent CNLDO and its potential use in diagnosis and follow up, focusing on novel inflammatory biomarkers: Systemic Immune-Inflammation Index (SII), Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Red cell distribution width (RDW), and Mean platelet volume (MPV).

Methods: A retrospective case-control study involving 76 CNLDO patients and 47 age-matched healthy controls was conducted.

Comprehensive Evaluation of Serpentine Aneurysms: a Systematic Review and Meta-analysis with a Subanalysis for Treatment Approaches.

Purpose: This systematic review and meta-analysis aimed to systematically evaluate and enhance the understanding of optimal management strategies for serpentine aneurysms.

Methods: A systematic search was conducted in Medline, Scopus, and Cochrane databases up to July 8, 2024, using relevant keywords. Studies included were case series, prospective or retrospective cohorts, or randomized controlled trials with data on clinical and angiographic outcomes of intracranial serpentine aneurysms.

Evaluation of the effectiveness of the training on "Home care of COVID-19 positive/suspicious patients" given to nursing students: A quasi-experimental study.

Background: This study aims to evaluate the effects of education on home care of infected or suspected COVID-19 patients on the levels of knowledge, anxiety, and awareness of nursing students in Turkey.

Materials And Methods: The study is in quasi-experimental design. A sample of 158 volunteer students studying nursing at a private university in Turkey was formed.

The global immune-nutrition-inflammation index (GINI) as a robust prognostic factor in glioblastoma patients treated with the standard stupp protocol.

Background: Systemic inflammation can significantly impact gliomas' onset, progression, and prognosis. Glioblastoma multiforme (GBM) represents the glioma subtype characterized by the most profound inflammatory and immunosuppressive states. Consequently, various blood-borne biomarkers have been scrutinized concerning their prognostic value in GBM patients.

How is social dominance related to our short-term memory? An EEG/ERP investigation of encoding and retrieval during a working memory task.

Social hierarchies exist in all societies and impact cognitive functions, brain mechanisms, social interactions, and behaviors. High status individuals often exhibit enhanced working memory (WM) performance compared to lower status individuals. This study examined whether individual differences in social dominance, as a predictor of future status, relate to WM abilities.

Effects of personality traits and mood induction on metamemory judgments and metacognitive beliefs.

Although the effects of mood and personality traits on memory performance have previously been studied, their relationship to the metamemory and metacognitive processes is still unknown. In this study, we investigated the effects of mood induction (positive and negative) and personality traits (extroverted and neurotics) on metacognitive beliefs, memory confidence, the judgment of learning (JOL) and feeling of knowing (FOK) judgments during face-name recognition tasks. One hundred twenty-seven participants who met the criteria based on their extraverted and neurotic personality scores on the Big Five Personality Inventory were randomly assigned to positive and negative mood induction conditions.

Urge Symptoms after Vaginal Uterosacral Plication in Urinary Incontinence Patients without Proximal Urethral Mobility: A Prospective Study.

Introduction: The primary objective of this study was to evaluate the impact of vaginal uterosacral plication on urge symptoms and quality of life in a cohort of patients with uterosacral ligament insufficiency and urge symptoms.

Methods: A total of 40 female patients were included in the study, and their posterior fornix was supported with gauze to simulate the surgical procedure. Uterosacral plication was applied to patients who experienced a decrease in urinary incontinence, nocturia, a sense of urgency, and a decrease in urge urinary incontinence symptoms or complete recovery.

A Novel Medium Access Policy Based on Reinforcement Learning in Energy-Harvesting Underwater Sensor Networks.

Underwater acoustic sensor networks (UASNs) are fundamental assets to enable discovery and utilization of sub-sea environments and have attracted both academia and industry to execute long-term underwater missions. Given the heightened significance of battery dependency in underwater wireless sensor networks, our objective is to maximize the amount of harvested energy underwater by adopting the TDMA time slot scheduling approach to prolong the operational lifetime of the sensors. In this study, we considered the spatial uncertainty of underwater ambient resources to improve the utilization of available energy and examine a stochastic model for piezoelectric energy harvesting.

Assessing the Efficacy of Cyanobacterial Strains as Growth Biostimulants in Saline Environments.

Soil salinity, which affects plant photosynthesis mechanisms, significantly limits plant productivity. Soil microorganisms, including cyanobacteria, can synthesize various exometabolites that contribute to plant growth and development in several ways. These microorganisms can increase plant tolerance to salt stress by secreting various phytoprotectants; therefore, it is highly relevant to study soil microorganisms adapted to high salinity and investigate their potential to increase plant resistance to salt stress.

The Effect of Nonpharmacological Methods on Preoperative Anxiety in Breast Surgery Patients: Meta-analysis.

Purpose: To investigate the effect of nonpharmacological methods on anxiety before breast surgery, using the meta-analysis method.

Design: A meta-analysis.

Methods: Nine electronic databases were searched to identify studies published up to October 2023.

Postoperative pain after total pulpotomy and root canal treatment in mature molars according to the new and traditional classifications of pulpitis: a prospective, randomized controlled trial.

Background: The aim of this study was to compare postoperative pain following total pulpotomy (TP) and root canal treatment (RCT) in mature molar teeth with irreversible pulpitis. To compare the traditional pulpitis classification system with the Wolters system in evaluating postoperative pain.

Methods: Eighty mandibular molars with irreversible pulpitis were included and classified according to the Wolters (moderate/severe pulpitis).

In vitro Chondrogenic Induction Promotes the Expression Level of IL-10 via the TGF-β/SMAD and Canonical Wnt/β-catenin Signaling Pathways in Exosomes Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells.

Current treatment approaches cannot exactly regenerate cartilage tissue. Regarding some problems encountered with cell therapy, exosomes are advantageous because of their "cell-free" nature. This study examines the relationship between IL-10 and TGF-β and Canonical Wnt/β-catenin signal pathways in human adipose tissue-derived MSCs exosomes (hAT-MSCs-Exos) after in vitro chondrogenic differentiation.

Success of custom total joint replacement simultaneous with orthognathic surgery in patients with idiopathic condylar resorption.

The aim of this study was to evaluate the aesthetic and functional outcomes of custom alloplastic total joint replacement combined with orthognathic surgery (cTJR + OS) in patients with idiopathic condylar resorption. Thirteen patients who underwent cTJR + OS between 2015 and 2022 were analysed retrospectively. Primary outcomes were maximum inter-incisal opening (MIO), scores for joint pain, jaw function, diet, sleep apnoea, and aesthetics.

Associations between anemia and dependence on basic and instrumental activities of daily living in older women.

Aim: The aim of the present study was to examine the relationship between anemia and basic and instrumental activities of daily living in older female patients.

Methods: 540 older female outpatients were included in this cross-sectional study. Anemia was defined as a hemoglobin below 12 g/dL.

True empty follicle syndrome is a subtype of oocyte maturation abnormalities.

Objective: To review the outcomes of in vitro maturation (IVM) and in vitro fertilization (IVF) in women with empty follicle syndrome (EFS). The study evaluated the genetic underpinnings of EFS by analyzing mutations.

Materials And Methods: This retrospective case series involving 17 women with EFS over at least 2 IVF cycles was conducted.

Tricuspid Valve Transcatheter Edge-to-Edge Repair (TriClip): Initial Outcomes and Experience in Türkiye.

Objective: This study aims to assess the efficacy and safety of tricuspid valve (TV) transcatheter edge-to-edge repair (TEER) procedures using the MitraClip or TriClip device in high-risk patients with severe secondary tricuspid regurgitation (TR) and provide Turkish-specific data on procedural outcomes and clinical follow-up.

Methods: This study enrolled 42 high-risk patients with severe secondary TR who underwent transcatheter edge-to-edge repair using either the MitraClip or TriClip device. Patient selection criteria included severe TR, high surgical risk (EuroScore ≥ 8 and Tricuspid Regurgitation Impact Severity Score (TRI-SCORE) ≥ 6), symptomatic despite medical therapy, and anatomical suitability for TriClip.

Innovative Fluorescent Polymers in Niosomal Carriers: A Novel Approach to Enhancing Cancer Therapy and Imaging.

Cancer is anticipated to become the pioneer reason of disease-related deaths worldwide in the next two decades, underscoring the urgent need for personalized and adaptive treatment strategies. These strategies are crucial due to the high variability in drug efficacy and the tendency of cancer cells to develop resistance. This study investigates the potential of theranostic nanotechnology using three innovative fluorescent polymers (FP-1, FP-2, and FP-3) encapsulated in niosomal carriers, combining therapy (chemotherapy and radiotherapy) with fluorescence imaging.

Influence of Ultrasonication and UV-C Processing on the Functional Characteristics and Anticarcinogenic Activity of Blackthorn Vinegar.

In recent years, consumer trends have been changing toward fresh food products such as fruit juice, vinegar, etc. that are a good source of bioactive components, high nutritional characteristics, and beneficial microorganisms. Blackthorn ( L.

Comprehensive antigenotoxic profile of endemic Petrak extracts against hydrogen peroxide induced toxicity.

Cyto/genotoxicity have been widespread utilized for the safety risk assessment of synthetic/natural chemicals. Plants can protect organisms from harmful effects of xenobiotics. On the other hand, plants can extract toxic molecules from the environment which may disrupt mitosis and cytokinesis.