Relationship between working posture/movement and measures to prevent low back pain among care workers: a cross-sectional study in the Kansai region of Japan.

We investigated the implementation of safe work practices for preventing low back pain (LBP) among care workers (CWs) to ascertain the interrelationships between appropriate device use and the frequency of working postures/movements that cause LBP. This cross-sectional study used an anonymous, self-administered questionnaire of CW team leaders (one per facility) working at long-term care facilities in Japan. Data on bed-height adjustment, the use of devices for repositioning in bed and bed- and wheelchair-transfer assistance, and the frequency of awkward postures/movements were cross-tabulated and analyzed using Haberman's residuals.

Visual exposure to green light therapy reduces knee joint pain and alters the lipidome in osteoarthritic rats.

Visual exposure to dim, green, light has been found to reduce pain levels in patients living with migraine, low back pain, and fibromyalgia. Preclinical studies discovered that the analgesic effect of green light was due to the central release of endogenous opioids and a reduction in inflammatory cytokines in the cerebrospinal fluid. The present study assessed the effect of green light therapy (GLT) on joint pain in a rat model of osteoarthritis (OA) and investigated the role of endolipids.

Neuropeptide Y Y2 receptors in acute and chronic pain and itch.

Pain and itch are regulated by a diverse array of neuropeptides and their receptors in superficial laminae of the spinal cord dorsal horn (DH). Neuropeptide Y (NPY) is normally expressed on DH neurons but not sensory neurons. By contrast, the Npy2r receptor (Y2) is expressed on the central and peripheral terminals of sensory neurons but not on DH neurons.

Cellular and Molecular Mechanisms of Hypertrophy of Ligamentum Flavum.

Hypertrophy of the ligamentum flavum (HLF) is a common contributor to lumbar spinal stenosis (LSS). Fibrosis is a core pathological factor of HLF resulting in degenerative LSS and associated low back pain. Although progress has been made in HLF research, the specific molecular mechanisms that promote HLF remain to be defined.

Impact of chronic low back pain on implicit motor imagery assessed by a new laterality judgment task.

It is clear that implicit motor imagery (IMI) is impaired by chronic pain in peripheral regions (hand, feet), but unclear in axial regions (neck, shoulder, back). Previous IMI tasks displayed small-amplitude movements of axial regions, which limits person-centered IMI processes mobilization. This study aimed to assess the impact of chronic low back pain (CLBP) on IMI processes with a new task displaying large-amplitude whole-body movements mobilizing the lumbar spine.

Anti-arthritic potential and antioxidant properties of infusion, fractions and flavonoid glycosides from Dipteryx alata (baru) leaves.

Ethnopharmacological Relevance: Dipteryx alata Vogel., popularly known as "baru", is a native species of Brazilian cerrado used by "Ribeirinhos" in the North Araguaia microregion. In the traditional medicine, maceration of barks or leaves infusion are used to treat back and muscle pain, osteoporosis and rheumatism.

Altering prosthetic alignment does not affect hip and low back joint loading during sit-to-stand in people with a transtibial amputation.

People with a transtibial amputation (TTA) have greater prevalence of low back and hip joint pain compared to the general population. Altered movement, loading patterns, and neuromuscular activation during daily tasks like sit-to-stand likely contribute to these high rates of pain. In addition, muscle activation, ground reaction forces, and trunk range of motion can be affected by prosthetic alignment during sit-to-stand.

Froin's Syndrome: A Comprehensive Review of the Literature and the Addition of Two New Cases.

Background: Froin's syndrome (FS) is a rare entity with uncertain prevalence and prognosis, defined by a pathognomonic triad: cerebrospinal fluid (CSF) xanthochromia, elevated protein levels in the CSF, and hypercoagulated CSF, usually obtained through lumbar puncturing below the level of a partial or complete spinal block.

Methods: We conducted a comprehensive review of the literature on FS from its first description in 1903 to December 2023, utilizing PubMed and Google Scholar, and included two new cases from our clinical practice.

Results: We describe two patients who suffered from Froin's syndrome secondary to spinal abscesses.

Protective effects of PDGF-AB/BB against cellular senescence in human intervertebral disc.

Cellular senescence, characterized by a permanent state of cell cycle arrest and a secretory phenotype contributing to inflammation and tissue deterioration, has emerged as a target for age-related interventions. Accumulation of senescent cells is closely linked with intervertebral disc (IVD) degeneration, a prevalent age-dependent chronic disorder causing low back pain. Previous studies have highlighted that platelet-derived growth factor (PDGF) mitigated IVD degeneration through anti-apoptosis, anti-inflammation, and pro-anabolism.

Plaque-like cutaneous mucinosis associated with pain: A case report.

Plaque-like cutaneous mucinosis (PCM) is a rare atypical subtype of Lichen myxedematosus, characterized by hyperpigmented plaques typically found on the midline trunk. We report the case of a 26-year-old woman with a 1-year history of painful, pruritic, hyperpigmented plaques over her spine. Physical examination revealed soft plaques in the midline of the back, and histopathology showed dermal mucin deposition, consistent with PCM.

Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration.

Background: Lower back pain, as a typical clinical symptom of spinal degenerative diseases, is emerging as a major social problem. According to recent researches, the primary cause of this problem is intervertebral disc degeneration (IVDD). IVDD is closely associated with factors such as age, genetics, mechanical stimulation (MS), and inadequate nutrition.

Percutaneous Vesselplasty for the Treatment of Vertebral Osteoporotic Collapse Fractures.

A 78-year-old woman with vertebral compression fractures (VCFs) and chronic back pain was the subject of this case study. To treat symptomatic VCFs, less invasive procedures such as balloon kyphoplasty and vertebroplasty were developed. Vertebroplasty involves injecting polymethylmethacrylate (PMMA) into the vertebral body to mechanically stabilize it.

Antinociceptive and antineuropathic effects of Trifolium resupinatum L. on formalin-induced nociception and cervical spinal cord hemi-contusion: Underlying Mechanisms.

Ethnopharmacological Relevance: Trifolium resupinatum L. (Fabaceae), known as Persian clover, ethnomedicinally used in Persian folk medicine to treat peritoneal inflammation, rheumatism, and back pain.

Aim Of The Study: To investigate the antineuropathic and antinociceptive activities of Trifolium resupinatum leaves essential oil (TREO) in male Wistar rats, as well as to explore the potential mechanisms of action.

Polyphenol-modified biomimetic bioadhesives for the therapy of annulus fibrosus defect and nucleus pulposus degeneration after discectomy.

Discectomy is the surgical standard of care to relieve low back pain caused by intervertebral disc (IVD) herniation. However, there remains annulus fibrosus (AF) defect and nucleus pulposus (NP) degeneration, which often result in recurrent herniation (re-herniation). Herein, we develop a polyphenol-modified waterborne polyurethane bioadhesives (PPU-glues) to promote therapy prognosis after discectomy.

What can I do for my low back pain? The Work In Progress questionnaire!

Background: There is growing evidence on Commitment Therapy for people with low back pain (LBP). A self-reported questionnaire is lacking which evaluates commitment by relying on the most recommended actions, the most important core outcome domains, and the most evidenced treatment options.

Aim: To describe the development and psychometric validation of the Work In Progress (WIP) questionnaire.

Two Acute Stroke Patients Whose Lower Back and Lower Limb Pain Hampered Their Rehabilitation: The Effectiveness of Peripheral Nerve Blocks.

Lower back and lower limb pain can hamper the rehabilitation of cerebral stroke patients. We report that peripheral nerve blocks enabled two patients to continue rehabilitation. Case 1 was an 83-year-old female with left hemiparesis due to cerebral infarction of the right basal ganglia.

Senolytics cocktail dasatinib and quercetin alleviate chondrocyte senescence and facet joint osteoarthritis in mice.

Background Context: Low back pain (LBP) is a pervasive issue, causing substantial economic burden and physical distress worldwide. Facet joint osteoarthritis (FJ OA) is believed to be a significant contributor to this problem. However, the precise role of chondrocyte senescence in FJ OA remains unclear, as does whether the clearance of chondrocyte senescence can alleviate the progression of FJ OA.

Deciphering the Effect of Hyaluronic Acid/Collagen Hydrogel for Pain Relief and Tissue Hydration in a Rat Model of Intervertebral Disc Degeneration.

Intervertebral disc (IVD) degeneration is one of the primary causes of low back pain, causing disability; hence, there is no regenerative nature of the current treatments. Hyaluronic acid (HA) was reported to facilitate tissue repair and alleviate pain. Herein, we determined the therapeutic effect of HA and type II collagen (COLII) hydrogel for tissue repair targeting pain in IVD degeneration.

Effects of Spinal Decompression and Segmental Spinal Instrumentation on Lower Limb Functionality in Patients with Spinal Osteoarthritis.

Spinal osteoarthritis, a degenerative condition of the spine, significantly impairs quality of life, causing pain, stiffness, and limited mobility. Treatment primarily aims to improve functionality and quality of life. This study investigated the effects of lower back surgery (e.

Machine learning in the diagnosis, management, and care of patients with low back pain: a scoping review of the literature and future directions.

Background Context: Low back pain (LBP) remains the leading cause of disability globally. In recent years, machine learning (ML) has emerged as a potentially useful tool to aid the diagnosis, management, and prognostication of LBP.

Purpose: In this review, we assess the scope of ML applications in the LBP literature and outline gaps and opportunities.

The role of diurnal variation in development of musculoskeletal pain during prolonged standing.

Background: Research suggests mechanical changes occur to the body over the course of the day including shrinking of the intervertebral disc height which can increase rotational stiffness and rigidity of the spinal column. Further, pain sensitivity has been observed to fluctuate throughout the day, suggesting variations in pain sensitivity. Previous work has identified biomechanical and neuromuscular features related to the development of musculoskeletal pain during prolonged standing; however, many protocols have not controlled for time of day.