The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats.

Background: Activation of Kv7 potassium channels may decrease the reactivity of mesolimbic dopaminergic neurons that are implicated in mediating the reinforcing effects of ethanol.

Objectives: The objective of this study was to determine whether the administration of the Kv7 potassium channel opener retigabine would decrease ethanol intake in Long Evans rats.

Methods: A limited access two-bottle choice model of alcohol (10% solution) consumption was used in this study.