Is more not always better? Untangling the impact of ESG disclosure transparency on idiosyncratic risk.

Environmental, social and governance (ESG) increasingly impacts firms' risk management and investment decisions. Based on instrumental stakeholder theory, this study uses data from Chinese-listed manufacturing firms from 2013 to 2021 to examine the relationship between ESG disclosure transparency and idiosyncratic risk (IR). Artificial intelligence (AI) intellectual property protection and institutional investor distraction are incorporated as moderating variables in examining this relationship.

Biodegradable silk fibroin membranes for potential localized treatment of melanoma: optimized preparation andstudy.

As a lethal skin cancer, melanoma is highly aggressive and metastatic with high recurrence rates and the common therapy is surgical resection followed by chemotherapy. To minimize the side effects of chemotherapeutic drugs and prevent tumor recurrence, localized therapy is a more suitable treatment method. Here, a fully biodegradable silk fibroin (SF) membrane loaded with the therapeutic drug doxorubicin (Dox) is fabricated for potential localized chemotherapy of melanoma.

TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma.

Intrinsic and acquired resistance represent major obstacles to optimize outcomes in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeted therapy in lung adenocarcinoma (LUAD). Hence, a deeper understanding of EGFR-TKI resistance mechanisms in LUAD will potentially assist in formulating strategies to delay or overcome such resistance. Herein, it was observed that trefoil factor 3 (TFF3) is a crucial mediator of the LUAD EGFR-TKI response.

Amelioration of arsenic-induced hepatic injury via sulfated glycosaminoglycan from swim bladder: Modulation of Nrf2 pathway and amino acid metabolism.

Arsenic, a known environmental pollutant with a carcinogenic risk, is associated with chronic liver toxicity. Prebiotic regulation represents an emerging dietary strategy to alleviate arsenic-induced hepatotoxicity; however, research in this area remains limited. This study employed sulfated swim bladder glycosaminoglycan (SBSG), a potential prebiotic, to assess its efficacy in mitigating arsenic-induced liver injury.

Citizens' engagement in health risk communication and preventive behaviors: the mediating role of perceived shared responsibility in the COVID-19 pandemic.

Background: In times of a public health emergency such as COVID-19, a government-centric approach may not be sufficient to contain the epidemic and ensure citizens' compliance. This study proposes a theoretical model that integrates individual-oriented, social-oriented, and community-oriented factors to predict individuals' engagement in preventive behaviors and citizen health emergency communication (CHEC). Perceived shared responsibility, which results from the communal nature of the pandemic, is tested as a mediator in the relationships between different motivations and behaviors in the context of COVID-19.

Anti-Obesity Effects of Adzuki Bean Saponins in Improving Lipid Metabolism Through Reducing Oxidative Stress and Alleviating Mitochondrial Abnormality by Activating the PI3K/Akt/GSK3β/β-Catenin Signaling Pathway.

Obesity is a chronic and complex disease defined by the excessive deposition of fat and is highly associated with oxidative stress. Adzuki bean saponins (ABS) showed anti-obesity activity in our previous in vivo study; however, the active saponins of adzuki beans and potential mechanisms are still unclear. This research aims to elucidate the anti-obesity effects of ABS in improving lipid metabolism and oxidative stress, exploring the effective ingredients and potential molecular mechanisms through UHPLC-QE-MS analysis, network pharmacology, bioinformatics, and in vitro experiments both in the 3T3-L1 cell line and HepG2 cell line.

Some Improvements on Good Lattice Point Sets.

Good lattice point (GLP) sets are a type of number-theoretic method widely utilized across various fields. Their space-filling property can be further improved, especially with large numbers of runs and factors. In this paper, Kullback-Leibler (KL) divergence is used to measure GLP sets.

The 1978 English boarding school influenza outbreak: where the classic SEIR model fails.

Previous work has failed to fit classic SEIR epidemic models satisfactorily to the prevalence data of the famous English boarding school 1978 influenza A/H1N1 outbreak during the children's pandemic. It is still an open question whether a biologically plausible model can fit the prevalence time series and the attack rate correctly. To construct the final model, we first used an intentionally very flexible and overfitted discrete-time epidemiologic model to learn the epidemiological features from the data.

Engineering a fluorescent probe for the visual and wearable detection of NH in foods, environment samples and biological imaging.

Hydrazine (NH), as an important chemical raw material widely used in many fields, caused serious harm to human, food and environment. Therefore, a smart fluorescent probe TPC-NH with intramolecular charge transfer (ICT) process was fabricated for colorimetric and fluorescent differentiating of NH in many samples. When TPC-NH met NH, blue emission at 451 nm was obviously observed attributed to the interruption of ICT process, resulting in the formation of the hydrazone structure.

PAMPHLET: PAM prediction HomoLogous-Enhancement toolkit for precise PAM prediction in CRISPR-Cas systems.

The CRISPR-Cas technology has revolutionized our ability to understand and engineer organisms, evolving from a singular Cas9 model to a diverse CRISPR toolbox. A critical bottleneck in developing new Cas proteins is identifying protospacer adjacent motif (PAM) sequences. Due to the limitations of experimental methods, bioinformatics approaches have become essential.

Critical review on the intervention effects of flavonoids from cereal grains and food legumes on lipid metabolism.

Obesity, often caused by disorders of lipid metabolism, is a global health concern. Flavonoids from staple grains and legumes are expected as a safer and more cost-effective alternative for the future development of dietary flavonoid-based anti-obesity dietary supplements or drugs. This review systematically summarized their content variation, metabolism in the human body, effects and molecular mechanisms on lipid metabolism.

Perceived feedback and school belonging: the mediating role of subjective well-being.

Introduction: This study examined the interplay between perceived feedback (PF), subjective wellbeing (SWB), and students' sense of belonging to school (SBS). School belonging is a key factor for decisions regarding academic studies, and is usually impacted by PF. The current study explored whether SWB mediates the established relationship between PF and SBS.

A Systematic Review of Aphantasia: Concept, Measurement, Neural Basis, and Theory Development.

People with aphantasia exhibit the inability to voluntarily generate or form mental imagery in their minds. Since the term "aphantasia" was proposed to describe this, it has gained increasing attention from psychiatrists, neuroscientists, and clinicians. Previous studies have mainly focused on the definition, prevalence, and measurement of aphantasia, its impacts on individuals' cognitive and emotional processing, and theoretical frameworks synthesizing existing findings, which have contributed greatly to our understanding of aphantasia.