34 results match your criteria: "BGSB University[Affiliation]"

Extensive research is now being conducted on the design and construction of logic circuits utilizing quantum-dot cellular automata (QCA) technology. This area of study is of great interest due to the inherent advantages it offers, such as its compact size, high speed, low power dissipation, and enhanced switching frequency in the nanoscale domain. This work presents a design of a highly efficient RAM cell in QCA, utilizing a combination of a 3-input and 5-input Majority Voter (MV) gate, together with a 2 × 1 Multiplexer (MUX).

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The utilization of stem cells in tissue engineering holds great promise as efficient tools for tissue regeneration and in treating numerous musculoskeletal diseases. However, several limiting factors, such as precise delivery and control of differentiation of these stem cells as well as mimicking the microenvironment required to modulate stem cell behaviour , have given rise to an urgent need for the development of new biomaterials which could be tailored to enhance cell renewal and/or direct cell fates. Keratin-rich biological materials offer several advantages, such as biocompatibility, tailorable mechanical properties, huge bioavailability, non-toxicity, non-immunogenic, and intrinsic tissue repair and/or regeneration capabilities, which makes them highly valued.

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Dengue virus (DENV) non-structural protein 1 (NS1) is a versatile quasi-protein essential for the multiplication of the virus. This study applied high-throughput virtual screening (HTVS) and molecular dynamics (MD) simulation to detect the potential marine natural compounds against the NS1 of DENV. The structure of the NS1 protein was retrieved from Protein Data Bank with (PDB ID: 4O6B).

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Intestinal parasitic infections pose a grave threat to human health, particularly in tropical and subtropical regions. The traditional manual microscopy system of intestinal parasite detection remains the gold standard procedure for diagnosing parasite cysts or eggs. This approach is costly, time-consuming (30 min per sample), highly tedious, and requires a specialist.

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Understanding the genetic diversity and population structure of pharmaceutically important endangered plant species is crucial for their conservation and sustainable use. Despite the continuous population decline in Trillium govanianum Wall. ex D.

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In the ever-evolving field of drug discovery, the integration of Artificial Intelligence (AI) and Machine Learning (ML) with cheminformatics has proven to be a powerful combination. Cheminformatics, which combines the principles of computer science and chemistry, is used to extract chemical information and search compound databases, while the application of AI and ML allows for the identification of potential hit compounds, optimization of synthesis routes, and prediction of drug efficacy and toxicity. This collaborative approach has led to the discovery, preclinical evaluations and approval of over 70 drugs in recent years.

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Plant invasion shifts soil microbiome and physico-chemical attributes along an elevational gradient in Kashmir Himalaya.

Environ Sci Pollut Res Int

July 2023

Centre for Biodiversity & Taxonomy, Department of Botany, University of Kashmir, Srinagar, 190 006, Jammu and Kashmir, India.

Soil microbial communities, being situated at the interface of aboveground plant and belowground soil systems, can play a pivotal role in determining ecosystem response to the drivers of global environmental change, including invasive species. In mountains, invasive plants occurring along elevational gradients offer a unique natural experimental system to investigate the impact of invasions in determining patterns and relationships of soil microbial diversity and nutrient pools at much shorter spatial distances. Here, we studied the impact of a global plant invader, Leucanthemum vulgare, on the diversity of soil microbiome and physico-chemical attributes along an elevational gradient (1760-2880 m) in Kashmir Himalaya.

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The daunting task of feeding an ever-growing population is an immense challenge for the contemporary scientific community, especially in view of the rapidly changing climate throughout the world. Amidst these threatening crises, we witness rapid development in genome editing (GE) technologies, revolutionizing the field of applied genomics and molecular breeding. Various GE tools have been developed during the last two decades, but the CRISPR/Cas system has most recently made a significant impact on crop improvement.

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Large-scale solar energy production is still a great deal of obstruction due to the unpredictability of solar power. The intermittent, chaotic, and random quality of solar energy supply has to be dealt with by some comprehensive solar forecasting technologies. Despite forecasting for the long-term, it becomes much more essential to predict short-term forecasts in minutes or even seconds prior.

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In this paper, a mathematical model for assessing the impact of COVID-19 on tuberculosis disease is proposed and analysed. There are pieces of evidence that patients with Tuberculosis (TB) have more chances of developing the SARS-CoV-2 infection. The mathematical model is qualitatively and quantitatively analysed by using the theory of stability analysis.

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The emerging resistance against commonly used antiparasitic drugs has driven investigators to explore alternative approaches using plant-derived active ingredients. These compounds have been tested for antiviral, antibacterial, and anthelmintic properties, particularly against adult worms. However, their effects on larval forms have been neglected.

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Glutathione (GSH) is an abundant tripeptide that can enhance plant tolerance to biotic and abiotic stress. Its main role is to counter free radicals and detoxify reactive oxygen species (ROS) generated in cells under unfavorable conditions. Moreover, along with other second messengers (such as ROS, calcium, nitric oxide, cyclic nucleotides, etc.

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The rise in antimicrobial resistance is a cause of serious concern since the ages. Therefore, a dire need to explore new antimicrobial entities that can combat against the increasing threat of antibiotic resistance is realized. Studies have shown that the activity of the strongest antibiotics has reduced drastically against many microbes such as microfungi and bacteria (Gram-positive and Gram-negative).

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In the developing world, parasites are responsible for causing several serious health problems, with relatively high infections in human beings. The traditional manual light microscopy process of parasite recognition remains the golden standard approach for the diagnosis of parasitic species, but this approach is time-consuming, highly tedious, and also difficult to maintain consistency but essential in parasitological classification for carrying out several experimental observations. Therefore, it is meaningful to apply deep learning to address these challenges.

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Soil nematodes contribute to nutrient cycling. This year-long study aimed to investigate the changes in the diversity of soil nematodes during the spring, summer, and winter seasons in rice fields at 24 sites and to determine the indicator nematode genera that inhibit the roots of rice plants. A total of 216 soil samples were collected during three seasons, and the collection of 72 root samples was carried out during rice cropping.

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The rhizosphere is the region around the plant roots where maximum microbial activities occur. In the rhizosphere, microorganisms' beneficial and harmful activities affect plant growth and development. The mutualistic rhizospheric bacteria which improve plant growth and health are known as plant growth-promoting rhizobacteria (PGPR).

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Objective: Diabetes is a chronic fatal disease that has affected millions of people all over the globe. Type 2 Diabetes Mellitus (T2DM) accounts for 90% of the affected population among all types of diabetes. Millions of T2DM patients remain undiagnosed due to lack of awareness and under resourced healthcare system.

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Throughout the ages, the common bean has been consumed by humanity as an important food staple crop and source of nutrition on a global scale. Since its domestication, a wide spectrum of phenotypic and genotypic investigations have been carried out to unravel the potential of this crop and to understand the process of nutrient accumulation along with other desirable characteristics. The common bean is one of the essential legume crops due to its high protein and micronutrient content.

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Ethnopharmacological Relevance: Microorganisms are developing resistance to synthetic drugs. As a result, the search for novel antimicrobial compounds has become an urgent need. Medicinal plants are commonly used as traditional medicine and Delphinium is one of the prominent genus used in the treatment of several diseases.

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Drought differs from other natural disasters in several respects, largely because of the complexity of a crop's response to it and also because we have the least understanding of a crop's inductive mechanism for addressing drought tolerance among all abiotic stressors. Overall, the growth and productivity of crops at a global level is now thought to be an issue that is more severe and arises more frequently due to climatic change-induced drought stress. Among the major crops, rice is a frontline staple cereal crop of the developing world and is critical to sustaining populations on a daily basis.

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UHPLC/ESI/MS/MS profiling followed by bioactivity guided isolation of () extract yielded two polyphenolic molecules, Methyl haematommate (PF-1) and Atraric acid (PF-2). These molecules were evaluated for bioactivity against five cancerous cell lines. The results revealed that atraric acid showed significant activity against ovarian cancer cell line (PA-1) having GI at 16.

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Nano-Drug Delivery Systems: Possible End to the Rising Threats of Tuberculosis.

J Biomed Nanotechnol

December 2021

Department of Bio-Resources, School of Biological Sciences, University of Kashmir, Srinagar 190006, J&K, India.

Tuberculosis (TB) is still one of the deadliest disease across the globe caused by (). invades host macrophages and other immune cells, modifies their lysosome trafficking proteins, prevents phagolysosomes formation, and inhibits the TNF receptor-dependent apoptosis in macrophages and monocytes. Tuberculosis (TB) killed 1.

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Article Synopsis
  • Protein modifications, especially phosphorylation, are essential for protein function and regulation in response to environmental changes and hormone signaling.
  • Phosphoproteomics focuses on identifying phosphate-modified proteins and their effects on protein structure, function, and localization, using advanced techniques for quantitative detection.
  • The review emphasizes novel biosensor technologies, such as fluorescence and nanobody-based systems, to detect phosphoproteins and diagnose diseases by identifying abnormal phosphorylation patterns.
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Plant pathology has been revolutionized by the emergence and intervention of next-generation sequencing technologies (NGS) which provide a fast, cost-effective, and reliable diagnostic for any class of pathogens. NGS has made tremendous advancements in the area of research and diagnostics of plant infecting viromes and has bridged plant virology with other advanced research fields like genome editing technologies. NGS in a broader perspective holds the potential for plant health improvement by diagnosing and mitigating the new or unusual symptoms caused by novel/unidentified viruses.

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Arid environments face extreme risk from contemporary climate change; therefore, predicting the shifts in species distribution range and niche breadth in these environments assumes urgent research priority. Here we report the potential distribution and predict future distribution range of two model plant species typically representing contrasting environments across Asia and Africa: hot-arid Ephedra foliata and cold-arid E. gerardiana.

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