Paternal adverse childhood experiences: Associations with infant DNA methylation.

Adverse childhood experiences (ACEs), or cumulative childhood stress exposures, such as abuse, neglect, and household dysfunction, predict later health problems in both the exposed individuals and their offspring. One potential explanation suggests exposure to early adversity predicts epigenetic modification, especially DNA methylation (DNAm), linked to later health. Stress experienced preconception by mothers may associate with DNAm in the next generation.

Morquio-like dysostosis multiplex presenting with neuronopathic features is a distinct -related phenotype.

Background: Morquio B disease (MBD) is a distinct -related dysostosis multiplex presenting a mild phenocopy of -related Morquio A disease. Previously reported cases from European countries carry the W273L variant on at least one allele and exhibit a pure skeletal phenotype (). Only a minority of MBD cases have been described with additional neuronopathic findings ().

Associations of peripheral blood DNA methylation and estimated monocyte proportion differences during infancy with toddler attachment style.

Attachment is a motivational system promoting felt security to a caregiver resulting in a persistent internal working model of interpersonal behavior. Attachment styles are developed in early social environments and predict future health and development outcomes with potential biological signatures, such as epigenetic modifications like DNA methylation (DNAm). Thus, we hypothesized infant DNAm would associate with toddler attachment styles.

Personal perspectives: Infant pain-A multidisciplinary journey.

Understanding of infant pain has been transformed in the past 30 years. From assumptions that newborns were insensitive to pain, fundamental work established not only the infants perceive pain, but also there are critical windows in which pain can have long-lasting consequences. My multidisciplinary work revealed that repetitive pain exposure during the late 2nd and 3rd trimesters of fetal life "ex-utero" in infants born very preterm is related to long-term adverse associations with altered brain development, programming of stress systems, and thereby neurodevelopment.

Morquio-B disease: Clinical and genetic characteristics of a distinct -related dysostosis multiplex.

Background: Morquio-B disease (MBD) is a distinct -related dysostosis multiplex involving the trabecular parts of long bones and spine, presenting a mild phenocopy of -related Morquio-A disease.

Methods: We analyzed 63 (n = 62 published) cases with MBD to describe their clinical, biochemical and genetic features.

Results: Forty-one of 51 cases with informative clinical data had including progressive growth impairment, kyphoscoliosis, coxa/genua valga, joint laxity, platyspondyly, odontoid hypoplasia.