External delay and dispersion correction of automatically sampled arterial blood with dual flow rates.

Objective: Arterial sampling for PET imaging often involves continuously measuring the radiotracer activity concentration in blood using an automatic blood sampling system (ABSS). We proposed and validated an external delay and dispersion correction procedure needed when a change in flow rate occurs during data acquisition. We also measured the external dispersion constant of [11C]CURB, [18F]FDG, [18F]FEPPA, and [18F]SynVesT-1.