C-Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary Exacerbations.

Objective: Although studies have examined changes in C-reactive protein (CRP) during pulmonary exacerbations (PEX) in people with cystic fibrosis (PwCF), few have evaluated CRP profiles across age groups. Here, we characterize age-related CRP responses to PEX treatment.

Methods: We measured CRP concentrations at the beginning and end of intravenous (IV) antibiotic therapy for PEX in 100 pediatric and 147 adult PwCF at 10 US CF Centers.

Upper cervical spinal cord atrophy in MS: Sex, menopause, and neurodegeneration.

Background: Spinal cord (SC) atrophy is a key imaging biomarker of progressive multiple sclerosis (MS). Progressive MS is more common in men and postmenopausal women.

Objective: Investigate the impact of sex and menopause on SC measurements in persons with MS (pwMS).

Validation Status of Electronic Sphygmomanometers in China: A National Survey.

Background: Although the information on the validation status of electronic sphygmomanometer (ES) devices in use in health care institutions and households is much more clinically relevant than that of ES models available on the market, it remains insufficient.

Methods: A national survey was conducted across all administrative regions of mainland China to assess the validation status of ESs. Fifty-eight cities were selected with stratification by municipality, provincial capital, and other cities, and health care institutions and households in each city were chosen by convenience to identify ES devices in use according to the study protocol.

Effect of Patient Positioning on CT Number Accuracy: A Phantom Study Comparing Energy Integrating and Deep Silicon Photon Counting Detector CT.

Objective: Patient positioning during clinical practice can be challenging, and mispositioning leads to a change in CT number. CT number fluctuation was assessed in single-energy (SE) EID, dual-energy (DE) EID, and deep silicon photon-counting detector (PCD) CT over water-equivalent diameter (WED) with different mispositions.

Methods: A phantom containing five clinically relevant inserts (Mercury Phantom, Gammex) was scanned on a clinical EID CT and a deep silicon PCD CT prototype at vertical positions of 0, 4, 8, and 12 cm.

[Origanum vulgare and hemorrhagic risk, about a case].

Introduction: The use of medicinal plants in Algeria is an ancestral practice that remains relevant today. The population relies on plants to treat various diseases and everyday ailments, which can be dangerous, especially when taking medication [1,2]. The interaction between plants and medication can lead to a modification of the plasma concentrations of the latter, which can impact its therapeutic effectiveness and be responsible for toxicity or therapeutic failure [1,2].

Arthroscopic Suprapectoral Biceps Tenodesis Using an Onlay Technique.

Tenodesis of the long head of biceps is a common shoulder surgical procedure. Tenodesis can be performed either arthroscopically or open and within the glenohumeral joint, within the bicipital groove, or below the pectoralis major tendon insertion. Arthroscopic tenodesis of the biceps tendon reduces the risk of infection.

An Automatic Deep-Radiomics Framework for Prostate Cancer Diagnosis and Stratification in Patients with Serum Prostate-Specific Antigen of 4.0-10.0 ng/mL: A Multicenter Retrospective Study.

Rationale And Objectives: To develop an automatic deep-radiomics framework that diagnoses and stratifies prostate cancer in patients with prostate-specific antigen (PSA) levels between 4 and 10 ng/mL.

Materials And Methods: A total of 1124 patients with histological results and PSA levels between 4 and 10 ng/mL were enrolled from one public dataset and two local institutions. An nnUNet was trained for prostate masks, and a feature extraction module identified suspicious lesion masks.

Tenecteplase Thrombolysis for Stroke up to 24 Hours After Onset With Perfusion Imaging Selection: The CHABLIS-T II Randomized Clinical Trial.

Background: Whether it is effective and safe to extend the time window of intravenous thrombolysis up to 24 hours after the last known well is unknown. We aimed to determine the efficacy and safety of tenecteplase in Chinese patients with acute ischemic stroke due to large/medium vessel occlusion within an extended time window.

Methods: Patients with ischemic stroke presenting 4.

Colon-targeted engineered postbiotics nanoparticles alleviate osteoporosis through the gut-bone axis.

The potential for mitigating intestinal inflammation through the gut-bone axis in the treatment of osteoporosis is significant. While various gut-derived postbiotics or bacterial metabolites have been created as dietary supplements to prevent or reverse bone loss, their efficacy and safety still need improvement. Herein, a colon-targeted drug delivery system is developed using surface engineering of polyvinyl butyrate nanoparticles by shellac resin to achieve sustained release of postbiotics butyric acid at the colorectal site.

Comparison of conventional diffusion-weighted imaging and multiplexed sensitivity-encoding combined with deep learning-based reconstruction in breast magnetic resonance imaging.

Purpose: To evaluate the feasibility of multiplexed sensitivity-encoding (MUSE) with deep learning-based reconstruction (DLR) for breast imaging in comparison with conventional diffusion-weighted imaging (DWI) and MUSE alone.

Methods: This study was conducted using conventional single-shot DWI and MUSE data of female participants who underwent breast magnetic resonance imaging (MRI) from June to December 2023. The k-space data in MUSE were reconstructed using both conventional reconstruction and DLR.

Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses.

Combination chemotherapy remains essential for clinical management of triple-negative breast cancer (TNBC). Consequently, responses to multiple single agents cannot be delineated at the single patient level, even though some patients might not require all drugs in the combination. Herein, we conduct multi-omic analyses of orthotopic TNBC patient-derived xenografts (PDXs) treated with single agent carboplatin, docetaxel, or the combination.

A feasibility study of using virtual noncontrast images synthesized from dual-energy computed tomography for radiotherapy treatment planning.

Background: In the traditional computed tomography (CT) simulation process, patients need to undergo CT scans before and after injection of iodine-based contrast agent, resulting in a cumbersome workflow and additional imaging dose. Contrast-enhanced spectral CT can synthesize true contrast-enhanced (TCE) images and virtual noncontrast (VNC) images in a single scan without geometric misalignment. To improve work efficiency and reduce patients' imaging dose, we studied the feasibility of using VNC images for radiotherapy treatment planning, with true noncontrast (TNC) images as references and explored its dosimetric advantages compared to using TCE images.

ACKR1ECs Promote Aortic Dissection Through Adjusting Macrophage Behavior.

Background: Type A aortic dissection (TAAD) is a life-threatening condition characterized by complex pathophysiology, in which macrophages play a critical but not yet fully understood role. This study focused on the role of endothelial cells with elevated expression of ACKR1 (atypical chemokine receptor 1) and their interaction with proinflammatory macrophages in TAAD development.

Methods: Single-cell transcriptomic analysis of human aortic tissues was used to identify cellular heterogeneity in TAAD.

Quadrivalent meningococcal tetanus toxoid-conjugate booster vaccination in children aged 10-12 years: phase III randomized trial complementary analysis of immune persistence 3-6 years after priming.

Immune persistence following primary vaccination with a single dose of meningococcal quadrivalent conjugate vaccines, MenACYW-TT/MCV4-CRM, at age 10-12 years was demonstrated. Most participants primed with MenACYW-TT and MCV4-CRM maintained seroprotective titers against all serogroups, suggesting continued protection. Priming with MenACYW-TT resulted in higher persistent titers for serogroups C, W, and Y than MCV4-CRM.

Earlier Initiation of Supervised Physical Rehabilitation Is Not Associated With Decreased Arthrofibrosis After Isolated Arthroscopic Anterior Cruciate Ligament Reconstruction.

Purpose: To identify whether the timing of supervised physical rehabilitation initiation after isolated arthroscopic anterior cruciate ligament reconstruction (ACLR) is associated with (1) diagnosis of arthrofibrosis and (2) surgical intervention for arthrofibrosis within 12 months after surgery.

Methods: Outpatient isolated arthroscopic ACLR procedures in 2017-2020 were identified from the Merative MarketScan database. The cohort was limited to patients aged 18 to 64 years who initiated supervised physical rehabilitation at 0 to 30 days postoperatively and had continuous enrollment in the database for 12 months before and after surgery.

Computational Simulation and Biophysical Study on Cerium Chloride-Induced B-to-Z Transition in (CG) DNA.

Rare earth elements have been shown to trigger the B-to-Z DNA transition in diverse self-assembled branched DNA architectures. Herein, we investigated the influence of cerium chloride on the conformational changes of DNA sequences containing repeated cytosine-guanine (CG) or guanine-cytosine (GC) sequences. The CD results show that (CG) repeats were susceptible to the formation of Z-DNA at low concentrations of CeCl.

Innervated Coculture Device to Model Peripheral Nerve-Mediated Fibroblast Activation.

Cutaneous wound healing is a complex process involving various cellular and molecular interactions, resulting in the formation of a collagen-rich scar with imperfect function and morphology. Dermal fibroblasts are crucial to successful wound healing, migrating to the wound site where they are activated to provide extracellular matrix remodeling and wound closure. Peripheral nerves have been shown to play an important role in wound healing, with loss or damage to these nerves often leading to impaired healing and the formation of chronic nonhealing wounds.

A Novel Description of Medial Meniscus Vascularization: A Multicenter Study Introducing the "Medial Meniscal Artery".

Background: The microvasculature of the human meniscus has been previously described by Arnoczky and Warren. However, to date, the qualitative and quantitative extra-articular vascular anatomy of the medial meniscus has not been characterized.

Purposes: To perform a qualitative and quantitative anatomic study of the extra-articular medial meniscal vasculature and to introduce the novel "medial meniscal artery" (MMA), potentially providing future guidelines for the treatment of meniscal abnormalities.

Comparative performance analysis of mixed metal oxide sensors for dual-sensing leveraging machine learning.

This paper presents the synthesis of mixed metal oxide (BaTiO: ZnO) (B: Z) sensors with various molar ratios using a low-temperature hydrothermal method for dual sensing applications (gas and acceleration). The sensor developed with an equal molar ratio of 1B:1Z, showcases superior performance compared to unmixed and alternative mixed metal oxide sensors. This equilibrium in ratios optimally enhances synergistic effects between elements B and Z, resulting in improved sensing properties.