[Transitional pain service in surgery as an optimal strategy for the treatment and prevention of chronic postoperative pain].

The problem of chronic postoperative pain (CPP) has remained relevant over the past decades, despite the active development of anesthesiology and surgery. Existing approaches to the treatment of acute postoperative pain do not provide effective prevention of CPP. The analysis of the results of studies on this problem was carried out.

Clinical validation of the novel CLIA-CA-62 assay efficacy for early-stage breast cancer detection.

Background: Without organized screening programs up to 60-70% of breast cancers are diagnosed at advanced stages that have significantly lower five-year survival rate and poorer outcomes, which is a serious global public health problem. The purpose of the blind clinical study was the assessment of the novel diagnostic chemiluminescent CLIA-CA-62 assay for early-stage breast cancer detection.

Methods: Blind serum samples of 196 BC patients with known TNM staging, 85% with DCIS, Stage I & IIA, and 73 healthy control subjects were analyzed with the CLIA-CA-62 and CA 15-3 ELISA assays.

The role of nutrition status correction in the rehabilitation of cancer patients.

Metabolic changes due to the progression of malignant neoplasms and the negative consequences of aggressive methods of its treatment lead to a decrease in food intake in patients, which contributes to the development of anorexia-cachexia syndrome in cancer patients due to complex interactions between pro-inflammatory cytokines and host metabolism. Within the framework of this article, the author analyzes the possibility of the influence of nutritional status in cancer patients. The analysis of the results of the study of a group of cancer patients with various nutritional statuses was carried out.

Different Phenotypes of Sarcomeric -Cardiomyopathy in the Same Family: Hypertrophic, Left Ventricular Noncompaction and Restrictive Phenotypes (in Association with Sarcoidosis).

The same variants in sarcomeric genes can lead to different cardiomyopathies within the same family. This gave rise to the concept of a continuum of sarcomeric cardiomyopathies. However, the manifestations and evolution of these cardiomyopathies in pathogenic variant carriers, including members of the same family, remains poorly understood.

Differential diagnosis of ascites in internal medicine: clinical case.

Ascites and hydrothorax may be the symptoms of congestive heart failure and do not always reflects presense of the decompensated liver cirrhosis. Clinical examination of patient with chronic hepatitis C which cyanosis of the lips, cervival veins pulsation, a triple heart rhythm indicated on pathology of the heart (constrictive pericarditis), which was confirmed by instrumental methods. Congestive heart failure has lead to the congestive liver in a young female patient.

Local repair of distal thoracal aortic dissections (Locus minoris resistencia).

The paper presents the method of local repair of distal aortic dissections. Local aortic grafting for surgical correction of type B dissecting aortic aneurysms helped to decrease hospital mortality up to 15.4%, the rate of paraparesis and multiorgan failure - up to 11.

Surgical treatment of a female patient with Turner's syndrome and a giant dissecting aneurysm of the ascending artery which occurred after two operations for aortic coarctation.

This paper reports a female patient with. Turner's syndrome and a giant aneurysm of the ascending aorta with pronounced aortic insufficiency in the presence of the bicuspid aortic valve, type II aortic dissection that occurred after two operations: resection of aortic coarctation with end-to-end anstomosis, recoarctation syndrome and aortic ascenoing-descending bypass grafting via the right-sided thoracotomy. The patient underwent prosthetics of the ascending aorta and aortic valve with ascending-descending repeated bypass grafting under conditions of complete peripheral cardiopulmonary bypass, hypothermia (22 degrees C) antegrade brain perfusion via the right subclavian artery.