Moringa oleifera Nanoparticles Demonstrate Antifungal Activity Against Plant Pathogenic Fungi.

Fungal diseases in plants are creating numerous problems in the developed and developing nations. Silver, a notable metal because of its inertness and its role in nanoscience, has received a considerable amount of focus in the development of an ecofriendly green solution to control many microbial infections. The herbal product from various plant sources with the combination of silver was used to develop nanoparticles, against the pathogens.

Phytocompounds of Onion Target Heat Shock Proteins (HSP70s) to Control Breast Cancer Malignancy.

Globally, breast cancer is one of the leading invasive cancers in women. Moreover, the use of chemotherapeutic drugs for treating cancer produces toxic side effects and has even led to drug resistance. This research paper focuses on targeting three heat shock proteins belonging to 70 kDa subfamily (HSP70s), predominantly, Mortalin, Binding Immunoglobulin Protein (BiP), and Stress Inducible HSP70 (Stress Inducible Heat Shock Protein 70) involved in breast cancer malignancy using different phytocompounds of onion.

A brief review of pre-installation requirements of earth-air heat exchanger system for space heating and cooling.

Demand for renewable energy sources has increased significantly during the past 15-20 years. Due to this demand, one positive scenario has occurred as there has been a decrease in the use of fossil fuels. Among various usages of the fuels, a significant amount of energy is being used in heating and cooling for commercial, domestic houses, etc.

Human Fungal Infection, Immune Response, and Clinical Challenge-a Perspective During COVID-19 Pandemic.

Fungi are a small but important part of the human microbiota and several fungi are familiar to the immune system, yet certain can cause infections in immunocompromised hosts and referred as opportunistic pathogens. The fungal coinfections in COVID-19 hosts with predisposing conditions and immunosuppressive medications are posing higher severity and death. The immunological counteraction (innate/adaptive immunity) is triggered when the PRRs on the host cells recognize the fungal PAMPs.

Virtually screened novel sulfathiazole derivatives as a potential drug candidate for methicillin-resistant and multidrug-resistant tuberculosis.

Methicillin-resistant (MRSA) and multidrug-resistant tuberculosis (MDR-TB) is a leading cause of severe hospital and infection-related morbidity and mortality in the general population. There is a critical need for dynamic, powerful medication candidates to combat MRSA and MDR-TB infections in this specific setting. As a result, the current research focuses on the development of novel sulfathiazole derivative compounds that could be used as anti-MRSA and anti-MDR-TB agents.

Estimating the Axial Compression Capacity of Concrete-Filled Double-Skin Tubular Columns with Metallic and Non-Metallic Composite Materials.

This research focuses on estimating the ACC (axial compression capacity) of concrete-filled double-skin tubular (CFDST) columns. The study utilised algorithms and 'six' evaluation methods (XGBoost, AdaBoost, Lasso, Ridge, Random Forest Regressor and artificial neural network (ANN) architecture-based regression) to study the empirical formulae and utilise the parameters as the research's features, in order to find the best model that has higher and accurate reliability by using the RMSE and R scores as performance evaluation metrics. Thus, by identifying the best model in empirical formulae for estimating the ACC of CFDST, the research offers a reliable model for future research.

Artificial Neural Network with a Cross-Validation Technique to Predict the Material Design of Eco-Friendly Engineered Geopolymer Composites.

A material-tailored special concrete composite that uses a synthetic fiber to make the concrete ductile and imposes strain-hardening characteristics with eco-friendly ingredients is known as an "engineered geopolymer composite (EGC)". Mix design of special concrete is always tedious, particularly without standards. Researchers used several artificial intelligence tools to analyze and design the special concrete.

Numerical Modelling of Geopolymer Concrete In-Filled Fibre-Reinforced Polymer Composite Columns Subjected to Axial Compression Loading.

In this research study, the performance of geopolymer concrete (GPC) in-filled fibre-reinforced polymer (FRP) composite (GPC-FRP) columns exposed to compressive loading is examined using the finite element (FE) analysis. The load-deflection behaviour is investigated by considering the impact of the strength of concrete, different fibre orientations and thicknesses of FRP tubes in terms of the diameter/thickness (D/t) ratio, surface friction in between the concrete and enclosing FRP tube, the lateral confinement and the axial stress distribution characteristics. The load-carrying capacity (LCC) of the GPC-FRP composite columns and cement concrete (CC) in-filled FRP composite (CC-FRP) columns is compared and the results imply that the LCC of the GPC-FRP composite columns is (0.

Photophysical Behaviour of Novel Quaternary Pyrenoyl Salts and Their Sensitivity Towards Bile Salt Micellization.

The present work describes the synthesis and characterization of pyrene derivatives, N-(1-Pyrenoylmethyl) pyridinium bromide (PM-PB) and N-(1-Pyrenoylmethyl)-N,N,N-triethylammonium bromide (PM-TAB). The photophysical behavior of these molecules has been studied in various protic and aprotic solvents. Using steady state fluorescence intensity, fluorescence anisotropy and dynamic fluorescence lifetime studies, the sensitivity of these molecules towards the micellization process of bile salts has been monitored.

Marine biome-derived secondary metabolites, a class of promising antineoplastic agents: A systematic review on their classification, mechanism of action and future perspectives.

Cancer is one of the most deadly diseases on the planet. Over the past decades, numerous antineoplastic compounds have been discovered from natural resources such as medicinal plants and marine species as part of multiple drug discovery initiatives. Notably, several marine flora (e.

Lipidomics: An excellent tool for chronic disease detection.

It has been known as almost all the cells consists a lipid molecule which has a considerable impact in various biological processes. Lipids have been investigated with a potential role for the formation of cellular membrane and thereby maintaining the structural integrity. Omics has placed as a combined technologies utilized for an exploaration of mechanistic actions in several kinds of molecules that make up the cells of an organism.

The exploration of the crystal nucleation parameters and physico-chemical analysis of a single crystal: 2-amino-4,6-dimethoxypyrimidinium hydrogen (2,3)-tartrate 2-amino-4,6-dimethoxypyrimidine.

This paper discusses the structural orientations and the physico-chemical properties of a single crystal of 2-amino-4,6-dimethoxypyrimidinium hydrogen (2,3)-tartrate 2-amino-4,6-dimethoxypyrimidine (2ADT). The experimental investigation of the properties of the compound improves the potential for the utilization of the crystalline compound in the fabrication of optical limiting and nonlinear optical devices. For the growth process, an organic nonlinear optical crystal of 2ADT is synthesized conventionally at varying molar concentrations to achieve an excellent yield.

Effective Multi Toxic Dyes Degradation Using Bio-Fabricated Silver Nanoparticles as a Green Catalyst.

Herein, we reported the preparation and characterization of silver nanoparticles from Kalanchoe brasiliensis leaves extract and their application in the photocatalytic degradation of Aniline Blue, Toludine Blue, Congo Red, Indigo Carmine, Auramine O, and Pyronin Y dyes. The synthesis of Kalanchoe brasiliensis extract derived silver nanoparticles (KK-AgNPs) was well characterized by several techniques. The surface plasma resonance (SPR) peak of 17 nm sized KK-AgNPs occurred at 445 nm, and the KK-AgNPs were stable for more than five months.

Mechanochemical Access to Functional Clickates with Nitro-Retentive Selectivity via Organocatalyzed Oxidative Azide-Olefin Cycloaddition.

4-Nitro-1,2,3-triazoles are crucial precursors for high energy materials, and their practical synthesis is a long-standing problem. Herein, we communicate a mechanochemical route for the selective synthesis of 4-nitro-1,2,3-triazoles via organocatalyzed oxidative [3 + 2] cycloaddition between β-nitrostyrenes and organic azides. Our conditions avoid divergent pathways and permit the retention of the valuable NO group on the product.

Effect of polyol osmolytes on the structure-function integrity and aggregation propensity of catalase: A comprehensive study based on spectroscopic and molecular dynamic simulation measurements.

Owing to the ability of catalase to function under oxidative stress vis-à-vis its industrial importance, the structure-function integrity of the enzyme is of prime concern. In the present study, polyols (glycerol, sorbitol, sucrose, xylitol), were evaluated for their ability to modulate structure, activity and aggregation of catalase using in vitro and in silico approaches. All polyols were found to increase catalase activity by decreasing K and increasing V resulting in enhanced catalytic efficiency (k/K) of the enzyme.

Unraveling the hazardous impact of diverse contaminants in the marine environment: Detection and remedial approach through nanomaterials and nano-biosensors.

Marine pollution is one of the most underlooked forms of pollution as it affects most aquatic lives and public health in the coastal area. The diverse form of the hazardous pollutant in the marine ecosystem leads the serious genetic level disorders and diseases which include cancer, diabetes, arthritis, reproductive, and neurological diseases such as Parkinson's, Alzheimer's, and several microbial infections. Therefore, a recent alarming study on these pollutants, the microplastics have been voiced out in many countries worldwide, it was even found to be in the human placenta.

Impact of benzo[a]pyrene with other pollutants induce the molecular alternation in the biological system: Existence, detection, and remediation methods.

The exposure of benzo [a]pyrene (BaP) in recent times is rather unavoidable than ever before. BaP emissions are sourced majorly from anthropogenic rather than natural provenance from wildfires and volcanic eruptions. A major under-looked source is via the consumption of foods that are deep-fried, grilled, and charcoal smoked foods (meats in particular).

A Systemic Review on the Synthesis, Characterization, and Applications of Palladium Nanoparticles in Biomedicine.

Palladium nanoparticles (Pd NPs) have been considered as a potential candidate in the field of biomedical applications due to its unique properties such as huge catalytic, hydrogen storage, and sensing behavior. Therefore, Pd NPs have shown to have a significant potential for the development of antimicrobials, wound healing, antioxidant, and anticancer property in recent days. There are plenty of reports that showed superior properties of noble metals.

Analysis of a solar still with photovoltaic modules and electrical heater - Energy and exergy approach.

The availability of drinkable water, along with food and air, is a fundamental human necessity. Because of the presence of higher amounts of salt and pollution, direct use of water from sources such as lakes, sea, rivers, and subsurface water reservoirs is not normally suggested. Solar is still a basic technology that can use solar energy to transform accessible waste or brackish water into drinkable water.

Investigating the binding mechanism of topiramate with bovine serum albumin using spectroscopic and computational methods.

Various spectroscopic techniques involving fluorescence spectroscopy, circular dichroism (CD), and computational approaches were used to elucidate the molecular aspects of interaction between the antiepileptic drug topiramate and the multifunctional transport protein bovine serum albumin (BSA) under physiological conditions. Topiramate quenched BSA fluorescence in a static quenching mode, according to the Stern-Volmer quenching constant (K ) data derived from fluorescence spectroscopy for the topiramate-BSA complex. The binding constant was also used to calculate the binding affinity for the topiramate-BSA interaction.

Mimusops elengi Flower-Mediated Green Silver Nanoparticles Control Staphylococcus aureus and Acinetobacter baumannii.

The use of antibiotics against infection-causing bacteria is inactivated, due to the presence of antibiotic-degrading enzymes. These enzymes resist the action of antibiotics and make difficult for the already existing antibiotics to break the drug resistance. Hence, there is a need to formulate alternate therapies against the enzymes providing multidrug resistance to bacteria including Staphylococcus aureus and Acinetobacter baumannii.

Performance analysis of a solar dryer integrated with thermal energy storage using PCM-Al2O3 nanofluids.

Solar energy will assist in lowering the price of fossil fuels. The current research is based on a study of a solar dryer with thermal storage that uses water and waste engine oil as the working medium at flow rates of 0.035, 0.

SARS-CoV-2 Inhibitors from Nigella Sativa.

The recently encountered severe acute respiratory syndrome coronavirus 2 creates huge predicaments among various countries. Lack of specific treatment of COVID-19 disease demands urgency in drug design against SARS-CoV-2 targets. Nigella sativa the miraculous herb native to South and Southwest Asia and belonging to the family Ranunculaceae, due to its beneficial bioactive properties, was used by us for performing in silico study to analyze the potential of its compounds so that they can target and inhibit SARS-COV-2 proteins including its main protease, the papain-like protease, its helicase, and also the RNA-dependent RNApolymerase, RNA-binding protein, Endoribonuclease, receptor-binding domain, and the RNA-binding domain of nucleocapsid phosphoprotein.