Promising Action of Cannabinoids on ER Stress-Mediated Neurodegeneration: An In Silico Investigation.

Neurodegeneration has been recognized as a clinical episode characterized by neuronal death, including dementia, cognitive impairment and movement disorder. Most of the neurodegenerative deficits, via clinical symptoms, includes common pathogenic features as protein misfolding and aggregation. Therefore, the focus highlights the cellular organelle endoplasmic reticulum (ER) critically linked with the quality control and protein homeostasis.

Phytocompounds From Edible Oil Seeds Target Hub Genes To Control Breast Cancer.

Breast cancer is one of the most commonly diagnosed cancers in woman which accounts for more than 1 in 10 new cancers in the entire world. The recently found four new potential hub genes that show a strong expression in breast cancer are CCNA2, CCNB1, MAD2L1, and RAD51. Nowadays, food habits and lifestyle of an individual are one of the factors for causing cancers.

Role of SELENBP1 and SELENOF in prostate cancer bioenergetics.

The contribution of selenium and selenoproteins in prostate cancer etiology remains elusive, potentially due to insufficient information regarding the biochemical pathways in which they are involved. There are twenty-five human selenocysteine-containing proteins or selenoproteins as well as a smaller class of selenium-containing proteins that do not include selenocysteine, and their cancer-associated aberrations, both genetic and functional, have evoked special interest, although their contribution to the metabolic reprogramming of prostate cancers remains has not been extensively studied. While benign prostate tissue exhibits a glycolytic phenotype, neoplastic events restore the truncated tricarboxylic acid cycle and enhance oxidative phosphorylation.

Screening of Anti-carcinogenic Properties of Phytocompounds from Allium ascalonicum for Treating Breast Cancer Through In Silico and In Vitro Approaches.

Plants, rich in phytocompounds, have been in usage since time immemorial for treating various diseases, namely, cancer. One such plant species, Allium ascalonicum (Shallot) belonging to Amaryllidaceae family is being studied here for its anti-carcinogenic properties against breast cancer. GC-MS characterization of A.

Prevalence and Early Prediction of Diabetes Using Machine Learning in North Kashmir: A Case Study of District Bandipora.

Diabetes is one of the biggest health problems that affect millions of people across the world. Uncontrolled diabetes can increase the risk of heart attack, cancer, kidney damage, blindness, and other illnesses. Researchers are motivated to create a Machine Learning methodology that can predict diabetes in the future.

Functional characterization of maltodextrin glucosidase for maltodextrin and glycogen metabolism in Vibrio vulnificus MO6-24/O.

Glycogen is important for transmission of V. vulnificus undergoing disparate environments of nutrient-rich host and nutrient-limited marine environment. The malZ gene of V.

Role of autophagy in tumor response to radiation: Implications for improving radiotherapy.

Autophagy is an evolutionary conserved, lysosome-involved cellular process that facilitates the recycling of damaged macromolecules, cellular structures, and organelles, thereby generating precursors for macromolecular biosynthesis through the salvage pathway. It plays an important role in mediating biological responses toward various stress, including those caused by ionizing radiation at the cellular, tissue, and systemic levels thereby implying an instrumental role in shaping the tumor responses to radiotherapy. While a successful execution of autophagy appears to facilitate cell survival, abortive or interruptions in the completion of autophagy drive cell death in a context-dependent manner.

Pisonia Alba Assisted Synthesis of Nanosilver for Wound Healing Activity.

Wound infection is a major clinical challenge, impacting patient morbidity and mortality, with significant economic implications. Our research focused on how Pisonia Alba (PA) leaves, which are used to treat wounds, are used to synthesize silver nanoparticles and study their wound healing property. UV-visible spectroscopy, X-ray diffraction analysis, and s electron microscope (SEM) analysis were employed to evaluate the synthesized silver nanoparticles.

Improving the performance of novel evacuated tube solar collector by using nanofluids: experimental study.

The main focus of the work is to determine the performance efficiency of water-%CuO nanofluids and water at varied flow rate of 0.035 lit/sec, 0.045 lit/sec, and 0.

Bioactive Compounds from Nyctanthes arbor tristis Linn as Potential Inhibitors of Janus Kinases (JAKs) Involved in Rheumatoid Arthritis.

Nyctanthes arbor tristis L (NAT) is one of the herbal plants whose parts are commonly used to treat diverse ailment including RA. Although the etiology of the autoimmune disorder RA is still unclear, actions of cytokines have been greatly associated with the mechanism of RA. Despite the huge development of drugs to combat this disorder, the search for alternative medicine is increasing due to the adverse effects of these synthetic drugs.

Synthesis and Characterization of Novel Schiff Bases Derived from 2-Butyl-4-chloro Imidazole for the Enhanced Antimicrobial Property.

In this study, a novel Schiff base was synthesized which comprises a core moiety of 2-butyl-4-chloro imidazole. The ligand was synthesized by the reaction between the carbonyl compound 4-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl) methyl] benzoate and primary hydrazine compounds such as 2,4-dinitrophenylhydrazine in the presence of an alcoholic solvent and an acid catalyst. The synthesized Schiff base ligand is characterized by mass and spectral analysis including NMR.

Myconanoparticles Break Antibiotic Resistance in Staphylococcus aureus and Acinetobacter baumannii.

In this current study, the extracts of endophytic fungi (Aspergillus niger) were utilized to synthesize the silver nanoparticles (AnNps). In silico screening was carried out by docking secondary metabolites of Aspergillus niger with drug-resistant proteins such as penicillin-binding protein (pbp2a) and clumping factor A of Staphylococcus aureus, penicillin-binding protein (PBP3), and outer membrane protein of Acinetobacter baumannii. The molecular docking analysis revealed the interaction between secondary metabolites of Aspergillus niger with virulence factors of the pathogenic bacteria.

Effects of foreign aid and energy aid inflows on renewable and non-renewable electricity production in BRICS countries.

We empirically examine the effects of overseas aggregate aid and energy aid inflows on renewable and non-renewable electricity production in selected BRICS countries (i.e., Brazil, India, China, and South Africa) from 1995 to 2015.

A comprehensive review on experimental, numerical and optimization analysis of EAHE and GSHP systems.

Geothermal energy is one type of renewable source of energy that can be used as shallow geothermal system for the use of cooling and heating of residential and commercial buildings. In this paper, an intense review is carried out on geothermal heating and cooling for air conditioning with a focus on Earth-Air Heat Exchanger (EAHE) and Ground Source Heat Pump (GSHP) systems. The study is carried out to understand the factors which have a significant effect on the performance of the EAHE and GSHP systems.

Examining the impact of electricity production on economic growth and environmental quality in Japan: a disaggregated level analysis.

For accelerating economic growth, the role of electricity production and consumption is undeniable. Thus, the economic growth aspect of electricity consumption has already been well established in the literature. However, the attainment of sustainable economic growth has become an important concern for most countries; mere focus on electricity consumption on economic growth is not sufficient.

Effect of pH on Diclofenac-Lysozyme Interaction: Structural and Functional Aspect.

As a nonsteroidal antiinflammatory drug, diclofenac (DCF) is used in the treatment of a variety of human ailments. It has already been reported that the use of this class of drugs for a longer duration is associated with numerous side effects such as cardiovascular implications, reno-medullary complications, etc. In the present study, the effect of DCF on the structure, stability, and function of lysozyme was studied.

Engineered green nanoparticles interact with Nigrospora oryzae isolated from infected leaves of Arachis hypogaea.

Oilseed crop diseases are a major concern around the world, particularly in India. The synthetic fungicides not only kill the pathogen, but they also harm the host plant and beneficial microbes and on continuous usage, they decrease the soil fertility. To overcome this problem, green nanotechnology has been a greater alternative with promising benefits.

Impact of industrial effluents on the environment and human health and their remediation using MOFs-based hybrid membrane filtration techniques.

The hazardous risk posed by industrial effluent discharge into the ecosystem has raised a plethora of environmental issues, public health, and safety concerns. The effluents from industries such as tanning, leather, petrochemicals, pharmaceuticals, and textiles are create significant stress on the aquatic ecosystem, which induces significant toxicity, involved in endocrine disruptions, and inhibits reproductive functions. Therefore, this review presented an overall abridgment of the effects of these effluents and their ability to synergize with modern pollutants such as pharmaceuticals, cosmetic chemicals, nanoparticles, and heavy metals.

Synthesis and Characterization of Tween-20 Capped Biosynthesized Silver Nanoparticles for Anticancer and Antimicrobial Property.

The Vitrus vinifera fruit extract was used to make silver nanoparticles (AgNPs) utilizing a green chemical technique. The biosynthesized Tween-20/Vitrus vinifera-AgNPs were observed by UV-Vis spectrophotometry. Fourier transform infrared spectroscopy, scanning transmission electron microscopy, selected area electron diffraction, and energy-dispersive X-ray spectroscopy were used to characterize the physiochemical properties.

Bioinformatics strategies for studying the molecular mechanisms of fungal extracellular vesicles with a focus on infection and immune responses.

Fungal extracellular vesicles (EVs) are released during pathogenesis and are found to be an opportunistic infection in most cases. EVs are immunocompetent with their host and have paved the way for new biomedical approaches to drug delivery and the treatment of complex diseases including cancer. With computing and processing advancements, the rise of bioinformatics tools for the evaluation of various parameters involved in fungal EVs has blossomed.

Autophagy and Programmed Cell Death Are Critical Pathways in Jasmonic Acid Mediated Saline Stress Tolerance in Oryza sativa.

Saline stress is the most limiting condition impacting the plant growth, development, and productivity. In this present study, jasmonic acid (JA) was used as a foliar spray on the rice seedlings grown under saline stress. Increase in photosynthetic pigments, anthocyanin, and total protein content was observed with JA treatment while NaCl showed reduction in biochemical constituents and enhanced antioxidant enzyme activity.

A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections.

As a significant public health hazard with several drug side effects during medical treatment, searching for novel therapeutic natural medicines is promising. Sulfated polysaccharides from algae, such as fucoidan, have been discovered to have a variety of medical applications, including antibacterial and immunomodulatory properties. The review emphasized on the utilization of fucoidan as an antiviral agent against viral infections by inhibiting their attachment and replication.

Safeguards and weightless of electronic chain of command consolidated for virtual patient evaluation.

The Internet of Things (IoT), 5G cellular technology, and Cyber-Physical Systems (CPS) are enabling a wide range of IoT-based application cases that are both intelligent. As one of the most impactful applications of the Internet of Things (IoT), healthcare makes use of AAL (Ambient Assisted Living), mobile health (mHealth), and electronic health (eHealth). Spending on health is a significant portion of people's income.