Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals.

BACKGROUNDWeakly virulent environmental mycobacteria (EM) can cause severe disease in HLA-DRB1*15:02 or 16:02 adults harboring neutralizing anti-IFN-γ autoantibodies (nAIGAs). The overall prevalence of nAIGAs in the general population is unknown, as are the penetrance of nAIGAs in HLA-DRB1*15:02 or 16:02 individuals and the proportion of patients with unexplained, adult-onset EM infections carrying nAIGAs.METHODSThis study analyzed the detection and neutralization of anti-IFN-γ autoantibodies (auto-Abs) from 8,430 healthy individuals of the general population, 257 HLA-DRB1*15:02 or 16:02 carriers, 1,063 patients with autoimmune disease, and 497 patients with unexplained severe disease due to EM.

Anxiety disorders and mood disorders in hospital doctors: a literature review.

This paper is focused on mental health among hospital doctors. This is a review of the literature dated January 1, 2005-December 31, 2019, from the MedLine and Scopus databases. The prevalence of post-traumatic stress disorder and anxiety disorders ranged 2.

Coverage of soft tissue defects in acute surgery for deep burns of the limbs.

Burns of the limbs affect 48.6% of burn patients. Injury mechanisms condition their depth and degree of extension.

Glomerular disease and acute kidney injury in Sudan: Demographics, histological diagnosis and outcome.

Background: Acute kidney injury (AKI) is a relatively common clinical condition, associated with high rates of mortality. Although there is extensive literature on the nature and consequence of AKI in the developed world, much less is known in the developing world and more specifically in sub-Saharan Africa (SSA).

Objectives: To describe the demographics, histological diagnosis and clinical course of patients presenting with AKI to a single centre in Sudan.

Factors associated with malaria chemoprophylaxis compliance among French service members deployed in Central African Republic.

Background: Malaria is a public health concern in the French armed forces, with 400-800 cases reported every year and three deaths in the past 2 years. However, lack of chemoprophylaxis (CP) compliance is often reported among service members. The aim of this study was to explore factors associated with CP compliance.

Diagnosis of skull fractures according to postmortem interval: an experimental approach in a porcine model.

Most studies on fracture morphology of fresh or dry bones, specifically skull bones, have a limited focus, and they are often based on observations rather than experimental tests. This study characterized pig cranial fractures sustained under known impact conditions. An impact machine (mobile carriage guided by columns) was used to perform a fracture on each skull.

Cardiovascular disease in patients with spondyloarthropathies.

Spondyloarthropathies are associated with a greater cardiovascular risk than expected based on the cardiac lesions known to occur in these diseases. The prevalence of several conventional risk factors is high in spondyloarthropathy patients, and chronic inflammation also contributes to premature plaque formation. In addition, susceptibility genes for spondyloarthropathies may be associated with an increased risk of cardiovascular disease.

Amyloid arthropathy and Waldenström macroglobulinemia.

Amyloid arthropathy occurs chiefly as a manifestation of beta(2) microglobulin amyloidosis in patients receiving chronic hemodialysis. AL amyloidosis complicating multiple myeloma is a less common cause. Amyloid arthropathy is exceedingly rare in patients with Waldenström macroglobulinemia.

RS3PE revealing recurrent non-Hodgkin's lymphoma.

A patient meeting published criteria for remitting seronegative symmetrical synovitis with pitting edema (RS3PE) was found to have a synchronous recurrence of non-Hodgkin's malignant lymphoma. Reported cases of RS3PE associated with hematological malignancies and other forms of cancer are reviewed.

HLA B27 and respiratory involvement in axial spondylarthropathies. A retrospective study in 107 male patients.

Objective: To conduct a retrospective study of respiratory involvement in axial spondylarthropathies according to HLA B27 status.

Method: Schöber's index, chest expansion and lung function parameters were measured in 107 male inpatients with spondylarthropathies, including 78 with and 29 without the HLA B27 antigen (groups I and II, respectively). Active or severe spondylarthropathy was defined based on widely used clinical and laboratory test parameters.