72 results match your criteria: "Azra Naheed Medical College[Affiliation]"

Background and objective This study aims to investigate thrombocytosis and thrombocytopenia in treatment-naïve rheumatoid arthritis (RA) patients, addressing the lack of data on their prevalence and clinical significance. By focusing on untreated patients, this study seeks to clarify the disease's natural course without confounding factors from prior therapies. The research is particularly important in the Pakistani context, where regional variations in RA presentation are underexplored.

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Background: Exhumation of bodies for forensic purposes serves as a pivotal tool in medico-legal investigations, yet there is scant data on the practice within the Pakistani context, particularly in the District of Hyderabad. Aim & Objective were to investigate the prevalence and outcomes of exhumations in Hyderabad, contributing to the knowledge base and understanding the cultural and legal factors influencing post-mortem examinations.

Methods: A descriptive, observational, and retrospective analysis of 95 medicolegal exhumations carried out over two years, examining demographic data, the interval between death and exhumation, putrefactive changes, and the determination of the cause of death.

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Objective This study aims to determine whether disease activity was associated with health-related quality of life (HRQoL) in the Pakistani population with systemic lupus erythematosus (SLE). Methods This cross-sectional study was conducted in the Rheumatology Department of the National Hospital & Medical Centre, Lahore, Pakistan, from April 2021 to June 2022. A sample of 60 patients, both male and female, diagnosed with a case of SLE was collected through the purposive sampling technique.

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Article Synopsis
  • Adhesive capsulitis, characterized by shoulder stiffness and pain, is linked to conditions like diabetes, trauma, and autoimmune diseases, with a higher incidence found in patients with type 2 diabetes.
  • The objective of a study conducted at Bahawal Victoria Hospital in Pakistan is to determine how common adhesive capsulitis is among patients with type 2 diabetes.
  • The study involves diagnosing adhesive capsulitis based on clinical assessments and examining 430 patients from February to August 2024, focusing on their diabetes management and demographics.
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Article Synopsis
  • Adrenal masses include various abnormal growths in the adrenal gland, with pseudocysts being the most common type of cysts; there are currently no specific guidelines for their management due to their rare occurrence.
  • A systematic review of 39 studies from 2000 to 2023 focused on the clinical and radiological characteristics of adrenal gland pseudocysts, analyzing data from 45 patients, primarily adult women.
  • Findings indicated that many patients were asymptomatic or experienced vague abdominal pain, with the most notable imaging result being cystic lesions with calcifications; surgical intervention was necessary in cases of compression, growth, or cancer suspicion, with a majority undergoing open surgery.
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Relationship of microvascular density and tumor-associated macrophages with orofacial squamous cell carcinoma progression.

Oral Surg Oral Med Oral Pathol Oral Radiol

October 2024

Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madina, Al Munawwarra, Saudi Arabia; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, 346, United Arab Emirates; Department of Dentistry, University of Jordan, Amman, Jordan; Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, 4400, Pakistan.

Objective: The current study aimed to investigate the characteristics of tumor-associated macrophages (TAMs) and their association with microvascular density (MVD) in tumor progression in different grades of orofacial squamous cell carcinoma (OSCC) in the Pakistani population.

Study Design: This prospective study included 234 patients with oral cancer reported at different hospitals in Pakistan diagnosed with OSCC. Tumors were graded on the Anneroth grading system and the association between the frequency of TAMs and MVD was examined in vivo.

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Moyamoya disease (MMD) is considered a primary disorder of an unknown etiology. In contrast, Moyamoya syndrome (MMS) refers to MMD associated with other underlying diseases, such as meningitis in childhood, neurofibromatosis type II, Down syndrome, cranial irradiation, and different types of anemias, particularly hemoglobinopathies. We aimed to provide a comprehensive clinicopathological overview of MMS.

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A total of 271 young Pakistani adults responded to a selfdesigned multiple choice-based questionnaire (α = 0.83) which was then used to assess the levels of knowledge regarding breast cancer susceptibility (BRCA) gene mutation. Overall knowledge levels were assessed using the sum score of each response; any possible significance between knowledge scores and educational backgrounds as well as gender were also tested.

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Objective To determine the frequency of restless legs syndrome (RLS) among Pakistani patients with type 2 diabetes mellitus. Methods This observational cross-sectional study was carried out in the Department of Medicine at Bahawal Victoria Hospital, Quaid-e-Azam Medical College, Bahawalpur, Pakistan, from January 2024 to May 2024. The National Institute of Health (NIH) diagnostic criteria were used to diagnose RLS.

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Background In cirrhotic patients with ascites, primary prevention of spontaneous bacterial peritonitis (SBP) is a key strategy to lower morbidity and death. Rifaximin and fluoroquinolone used alternately as main prophylaxis are as effective as reported. This study aimed to compare the frequency of occurrence of SBP in patients with decompensated chronic liver disease treated with rifaximin alone and in combination with fluoroquinolone.

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Background: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as a prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers. This study analyzed the diagnostic/prognostic potential and clinical implications of CDCA8 across diverse cancers.

Methods: Bioinformatics and molecular experiments.

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Refractory Sarcoidosis.

J Ayub Med Coll Abbottabad

February 2024

Department of Rheumatology, National Hospital and Medical Center, Lahore, Pakistan.

A multi-organ granulomatous disease with characteristic lung manifestations, sarcoidosis generally responds well to glucocorticoid therapy but 10% of cases are refractory necessitating immunosuppressive therapy. A 58-year-old lady presented with a dry cough and progressively worsening shortness of breath for the last 12 months. On investigation, her ESR was raised but cultures, malignancy screen and TB quantiferon were negative.

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Lupus Vasculitis.

J Ayub Med Coll Abbottabad

February 2024

Department of Medicine & Allied, Azra Naheed Medical College, Superior University Lahore, Pakistan.

We present the case of a 30-year-old woman who presented with 8-month history of intermittent fever, joint pains with morning stiffness, recurrent oral ulcers, photosensitivity, weight loss and hair fall. For the last 2 months, she had developed a dry cough with progressive shortening of breath. On examination, a cachexic lady with malar hyperpigmentation, alopecia, pallor, nail dystrophy and erythema over her hands and feet were noted.

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Objective: To determine the association of serum kisspeptin, leptin, and other hormonal profile with non-obstructive azoospermia (NOA) in infertile male subjects.

Methods: This cross-sectional study was conducted at Australian Concept Infertility Medical Center, and Ziauddin University, Karachi from March 2018 to March 2020. The duration of the study was two years.

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Antibiotic resistance genes prevalence prediction and interpretation in beaches affected by urban wastewater discharge.

One Health

December 2023

Department of Oriental Medicine and Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si 17104, South Korea.

Background: The annual death toll of over 1.2 million worldwide is attributed to infections caused by resistant bacteria, driven by the significant impact of antibiotic misuse and overuse in spreading these bacteria and their associated antibiotic resistance genes (ARGs). While limited data suggest the presence of ARGs in beach environments, efficient prediction tools are needed for monitoring and detecting ARGs to ensure public health safety.

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The study aimed to synthesize zinc nanoparticles (Zn-NPs) using an aqueous extract derived from Acacia modesta Wall. leaves. Several characterization techniques were employed to confirm the successful formation of zinc nanoparticles.

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Background: Genus (Apiaceae) known as hedge parsley, encompasses 11-13 species distributed worldwide and shows potential pharmacological uses. Its phytochemical pattern is highly diversified including many phenolic and terpenic compounds.

Objective: This research-review provides new highlighting of structural organizations, structure-activity trends, taxonomical, tissue and geographical distribution of phytocompounds of genus from extensive statistical analyses of available data.

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Gastrointestinal (GI) intestinal stromal tumors account for 60% of mesenchymal GI tract tumors commonly located in the stomach and small intestine, predominantly solid tumors that rarely undergo cystic degeneration. A 65-year-old patient with increasing upper abdominal swelling and a computed tomography scan abdomen showed a large unilocular 17 × 16 × 15 cm lesion. A colossal cystic swelling in the lesser omentum, anterior to the stomach, was found upon exploration.

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Following the "rule of 2", Meckel's Diverticulum (MD) is 2 inches or 5cm long. However, we report the case of an extremely large MD. To the best of our elucidated literature search, it is the first case of Giant Meckel's Diverticulum (GMD) from Pakistan presenting with post-traumatic hemoperitoneum.

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As we head into the third year of the COVID-19 pandemic, there is an increasing need to consider the long-term mental health outcomes of health care workers (HCWs) who have experienced overwhelming work pressure, economic and social deprivation, burnout, and post-traumatic stress disorder (PTSD). This scoping umbrella review summarizes the mental health outcomes of published evidence syntheses on HCWs worldwide. We analyzed 39 evidence syntheses representing the findings from 1297 primary studies.

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Proteus syndrome is a rare disease manifested by progressive segmental overgrowth involving the skeletal, Cutaneous, subcutaneous, and nervous systems. We report the case of a 24-year-old female who was born with no obvious abnormality at birth. From the age of 1 year, she developed asymmetric enlargement of her left upper limb and bilateral lower limbs leading to enlargement of the right-hand phalanges with radial deviation, enlargement of the right big toe, lateral deviation of left foot, and discrepancy in the length of lower extremities and kyphoscoliosis.

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Rabies is an infectious viral disease endemic worldwide and is fatal after the onset of clinical symptoms. In 99% of cases, dogs contribute to infectious viral transmission in humans. It causes approximately 10,000 deaths per year, mainly in Asia and Africa, with 95% of deaths occurring in Asia alone.

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Objective: To determine the association between periodontal disease and low birth weight among pregnant women.

Methods: Data for this case-control study was collected from June 2019 till February 2020. All women in the Gynecology Department of Lady Willingdon Hospital, Lahore, who had delivered a baby within the last 24 h were invited to participate.

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Biomechanical effects of high heeled shoes on neck pain among females: A narrative review.

J Pak Med Assoc

February 2023

Imran Idrees Institute of Rehabilitation Sciences, Sialkot Medical College, Sialkot, Pakistan.

Neck pain is the fourth leading cause of disability, and is the most common musculoskeletal disorder. High-heel shoes, one of the significant identities of females, cause pain in the neck as well as in feet and ankle regions. The current narrative review was planned to explore evidence to highlight the biomechanical factors of high-heel shoes as the source of neck pain, which mostly remains undiagnosed.

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