Adaptation of antibiotics and antifungal strategy to preoperative biliary drainage to improve postoperative outcomes after pancreatic head resection.

Background: Biliary contamination significantly correlates with major comorbidities during pancreatic head resection. Recently, a piperacillin-tazobactam prophylaxis demonstrated a lower rate of infectious complications (IC) and postoperative pancreatic fistula (POPF) in this population. However, bacterial contamination is rare in patients without a preoperative biliary drainage (PBD) and probably could not benefit from this antibiotic.

Robotic versus laparoscopic liver resection for difficult posterosuperior segments: a systematic review with a meta-analysis of propensity-score matched studies.

Background: The outcomes of minimally invasive liver surgery for posterosuperior segments (PS) are still debated. Since the results of ongoing trials focusing on the results of laparoscopic liver resection (LLR) and robotic liver resection (RLR) in this setting are still awaited, the best evidence currently comes from retrospective propensity-score matched (PSM) studies. The aim of this meta-analysis was to assess the outcomes of RLR for difficult located lesions and to provide evidence for its use in clinical practice.

The Characterization of Natural Resins and a Study of Their Degradation in Interactions with Zinc Oxide Pigment.

In the last few years, the role of science in Cultural Heritage has assumed greater significance since diagnostics have become essential for the characterization of artworks. The development of conservation strategies involves growing the study of artworks and the knowledge of the materials used against the degradation plaguing the painted surfaces. This work focuses on the investigation of the degradation processes involving paintings on canvas, in particular delamination and progressive deterioration of the painted surfaces.

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After the normalization of social media in the Public Administration, they have become crucial to increasing citizen satisfaction. Alexandria Hospital has created a compliant website and an active presence on Facebook, Instagram, LinkedIn, X and YouTube. The main objectives of the "True or False" campaign are to educate the public on health issues, fight misinformation and evaluate knowledge on prevention.

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The initiative "Le parole della ricerca," launched in 2021, aims to enhance public understanding of health research through digital communication, using visual storytelling and local influencers. The project simplified complex research terms, linked to the DAIRI's activities, into 20 key concepts, illustrated by Gastini, and shared through social media. This campaign involved professionals explaining their work with the support of art, increasing public engagement.

Geological and mineralogical characterization of fibrous tremolite from Iacolinei quarry (Basilicata, Italy).

Naturally Occurring Asbestos (NOA) has drawn the attention worldwide when investigation revealed an increased incidence of malignant mesothelioma in population living near NOA sites. In Basilicata region (South Italy), population living in the villages of Castelluccio Superiore and Inferiore, Lauria, Latronico, Episcopia, San Severino Lucano, and Francavilla in Sinni may be considered at high risk of asbestos exposure because these villages are either surrounded by or built on NOA-rich ophiolitic outcrops. In this work we investigated an asbestos tremolite sample coming from the ophiolitic rocks outcropping in the quarry of Iacolinei, widely used in the past to extract aggregates for various applications.

Prostate-Specific Membrane Antigen Radioligand Therapy in Non-Prostate Cancers: Where Do We Stand?

Introduction: The term theragnostic refers to the combination of a predictive imaging biomarker with a therapeutic agent. The promising application of prostate-specific membrane antigen (PSMA)-based radiopharmaceuticals in the imaging and treatment of prostate cancer (PCa) patients opens the way to investigate a possible role of PSMA-based radiopharmaceuticals in cancers beyond the prostate. Therefore, the aim of this review was to evaluate the role of Lu-PSMA radioligand therapy (RLT) in malignancies other than prostate cancer by evaluating preclinical, clinical studies, and ongoing clinical trials.

Glycemic control and cancer outcomes in oncologic patients with diabetes: an Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), Italian Society of Pharmacology (SIF) multidisciplinary critical view.

Background:  Increasing evidence suggests that diabetes increases the risk of developing different types of cancer. Hyperinsulinemia, hyperglycemia and chronic inflammation, characteristic of diabetes, could represent possible mechanisms involved in cancer development in diabetic patients. At the same time, cancer increases the risk of developing new-onset diabetes, mainly caused by the use of specific anticancer therapies.

Diabetes and Cancer: The Perfect Storm and a PRICE to Pay.

Diabetes, obesity, cardiovascular diseases, and cancer are noncommunicable diseases representing the main global health challenges of the current century [...

Self-care behaviours and their determinants in people affected by coronary heart disease.

Objective: To describe self-care in Italian adults with coronary heart disease and to identify sociodemographic and clinical determinants of self-care.

Design: This is a cross-sectional analysis of data from the Italian multicentre longitudinal study.

Methods: We used the follow instruments: Self-Care of coronary heart disease inventory, Self-care Self Efficacy Scale, Charlson Comorbidity Index and Sociodemographic questionnaire.

Prostate-Specific Membrane Antigen Positron Emission Tomography Oncological Applications beyond Prostate Cancer in Comparison to Other Radiopharmaceuticals.

Background: Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein overexpressed on the surface of tumor cells in most of the patients affected by prostate adenocarcinoma (PCa). However, PSMA expression has also been demonstrated in the endothelial cells of newly formed vessels of various solid tumors, suggesting a role for PSMA in neoangiogenesis. In this scenario, gallium-68 (Ga) or fluoro-18 (F)-labeled PSMA positron emission tomography (PET) may play a role in tumors other than PCa, generally evaluated employing other radiopharmaceuticals targeting different pathways.

Environmental diseases, recognition for care: A qualitative study of nurses' perceptions.

Objectives: This study aims to investigate hospital nurses' perceptions of illness due to environmental exposures.

Design: A qualitative exploratory study, designed in accordance with the specified reporting guidelines for qualitative research.

Sample: Nurses working in Italian hospitals.

Psychometric testing of the caregiver contribution to self-care of coronary heart disease inventory.

Background: Caregivers are important contributors to the self-care of patients with coronary heart disease (CHD).

Aims: The aims of this study are to describe the development and psychometric properties of the caregiver contribution to self-care of coronary heart disease inventory (CC-SC-CHDI).

Methods: The CC-SC-CHDI was developed from the patient version of the scale, the Self-care of Coronary Heart Disease Inventory (SC-CHDI) and translated into Italian using forward and backward translation.

The clinical trial activation process: a case study of an Italian public hospital.

Background/aims: In order to make the centers more attractive to trial sponsors, in recent years, some research institutions around the world have pursued projects to reorganize the pathway of trial activation, developing new organizational models to improve the activation process and reduce its times. This study aims at analyzing and reorganizing the start-up phase of trials conducted at the Research and Innovation Department (DAIRI) of the Public Hospital of Alessandria (Italy).

Methods: A project was carried out to reorganize the trial authorization process at DAIRI by involving the three facilities responsible for this pathway: clinical trial center (CTC), ethics committee secretariat (ESC), and administrative coordination (AC).

Wound Repair and Ca Signalling Interplay: The Role of Ca Channels in Skin.

The process of wound healing is intricate and tightly controlled, involving a number of different cellular and molecular processes. Numerous cellular functions, especially those related to wound healing, depend critically on calcium ions (Ca). Ca channels are proteins involved in signal transduction and communication inside cells that allow calcium ions to pass through cell membranes.