2 results match your criteria: "Azienda Ospedaliera-University of Verona[Affiliation]"

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.

Nat Commun

September 2014

1] Department of Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, UK [2] Department of Haematology, University of Cambridge, Long Road, Cambridge CB2 0QQ, UK.

The analysis of rich catalogues of genetic variation from population-based sequencing provides an opportunity to screen for functional effects. Here we report a rare variant in APOC3 (rs138326449-A, minor allele frequency ~0.25% (UK)) associated with plasma triglyceride (TG) levels (-1.

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Article Synopsis
  • The INCIPE study examined the prevalence of chronic kidney disease (CKD) in 6200 Caucasian patients aged 40 and older in northeastern Italy, revealing a CKD prevalence of 13.2%.
  • Comparatively, this prevalence is lower than the 20.3% reported in U.S. Caucasians, largely due to differences in CKD stage 3 rates.
  • The study suggests that higher prevalence of renal risk factors in the U.S. contributes to the more significant CKD issue in that population compared to northeastern Italy.
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