Unicondylar knee prosthesis: our experience.

Aim Of The Study: To compare unicompartmental knee arthroplasty with "all poly" tibial component and "metal back" from a clinical and functional point of view.

Materials And Methods: We evaluated prospectively 50 patients who underwent unicompartmental knee replacement at the Orthopedic Clinic of the University of Trieste. Patients were split into two groups (A and B); in patients from group A has been implanted a Mitus prosthesis (Link) with "all poly" tibial component, in patients from Group B has been implanted an Allegretto prosthesis (Zimmer) with a "metal back" tibial component.

Autologous transplantation and maintenance therapy in multiple myeloma.

Background: This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter of body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and compared lenalidomide maintenance therapy with no maintenance therapy in patients with newly diagnosed multiple myeloma.

Methods: We randomly assigned 273 patients 65 years of age or younger to high-dose melphalan plus stem-cell transplantation or MPR consolidation therapy after induction, and 251 patients to lenalidomide maintenance therapy or no maintenance therapy. The primary end point was progression-free survival.

Psoriasis beyond the skin surface: a pilot study on the ocular involvement.

The ocular involvement in psoriasis is not a completely well-known problem. The ophthalmologic involvement occurs in about 10 % of patients, particularly in case of arthropathic or pustular psoriasis. Ocular lesions are more common in males, and they often occur during psoriasis exacerbations.

Successful treatment of an overlapping choriocapillaritis between multifocal choroiditis and acute zonal occult outer retinopathy (AZOOR) with adalimumab (Humira™).

To report a case of overlapping choriocapillaritis that initially presented as multifocal choroiditis (MFC) but later showed features compatible with acute zonal occult outer retinopathy (AZOOR) resistant to standard immunosuppression that responded only to adalimumad therapy. A 41-year-old patient presented with multiple small, discrete yellow-whitish spots in both eyes, compatible with MFC. A few weeks later, despite treatment with sub-Tenon and systemic corticosteroids, a choroidal neovascularization occurred in the right eye.

Multiple sclerosis: long time modifications of seasonal differences in the frequency of clinical attacks.

Previous papers show different patterns of seasonal distribution of multiple sclerosis attacks. This paper compares long-time modifications. Salerno MS registry (Southern Italy), was reviewed, including 189 patients, age onset 12-51 years (mean = 29.

Adalimumab (Humira™): a promising monoclonal anti-tumor necrosis factor alpha in ophthalmology.

Tumor necrosis factor alpha (TNF-α) is a key soluble mediator involved in the inflammatory cascade of many disorders including uveitis. Among the anti-TNF-α agents, one of the most used in immune-mediated diseases, such as inflammatory arthropathies, is adalimumab (Humira™, Abbott Pharmaceutical Inc.), a fully humanized antibody.

[HPV infection: comparison between morphological studies and molecular biology].

Human Papilloma Virus plays an essential role in the development of cervical cancer. We investigated the global prevalence of Human Papilloma Virus infection in a population of 699 women recruited at the Ospedali Riuniti in Foggia for gynaecological controls from September 2005 to March 2007, and compared with a group of 90 women, selected on clinical aspects for Human Papilloma Virus features. The observed prevalence was 27.