64 results match your criteria: "Azienda Ospedaliera Universitaria Di Cagliari[Affiliation]"
J Stroke
May 2021
Department of Neurology & Stroke Program, University of Maryland School of Medicine, Baltimore, MD, USA.
The optimal management of patients with asymptomatic carotid stenosis (ACS) is the subject of extensive debate. According to the 2017 European Society for Vascular Surgery guidelines, carotid endarterectomy should (Class IIa; Level of Evidence: B) or carotid artery stenting may be considered (Class IIb; Level of Evidence: B) in the presence of one or more clinical/imaging characteristics that may be associated with an increased risk of late ipsilateral stroke (e.g.
View Article and Find Full Text PDFRisk Manag Healthc Policy
April 2021
Department of Surgical Science, University of Cagliari, Eye Clinic, Cagliari, Italy.
The pandemic of coronavirus disease 2019 (COVID-19) has led many countries of the world to impose a series of containment measures such as lockdowns (mass quarantines), curfews or similar restrictions (eg, stay-at-home orders, or shelter-in-place orders). All these restrictions were established in order to limit spread of COVID-19. Thus, approximately 3.
View Article and Find Full Text PDFPhys Med
April 2021
Department of Radiology, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA. Electronic address:
Purpose: Optimization of CT scan practices can help achieve and maintain optimal radiation protection. The aim was to assess centering, scan length, and positioning of patients undergoing chest CT for suspected or known COVID-19 pneumonia and to investigate their effect on associated radiation doses.
Methods: With respective approvals from institutional review boards, we compiled CT imaging and radiation dose data from four hospitals belonging to four countries (Brazil, Iran, Italy, and USA) on 400 adult patients who underwent chest CT for suspected or known COVID-19 pneumonia between April 2020 and August 2020.
Am J Ophthalmol Case Rep
June 2021
Eye Clinic, Department of Surgical Science, University of Cagliari, Cagliari, Italy.
Purpose: To report an unusual non-iatrogenic case of central macular and posterior full-thickness retinal holes (FTRHs).
Observations: A 60-year-old man presented with a progressive visual loss in the right eye. A complete ophthalmological evaluation including best corrected visual acuity (BCVA) measurement, fundus examination and spectral - domain optical coherence tomography (SD-OCT) was performed.
Crit Rev Oncol Hematol
January 2021
Medical Oncology Unit, University Hospital and University of Cagliari, Cagliari, Italy. Oncologia Medica, Azienda Ospedaliera Universitaria di Cagliari, Presidio Policlinico Universitario "Duilio Casula" S.S. 554, Km 4,500 Bivio per Sestu, 09042 Monserrato, Cagliari, Italy. Electronic address:
Advanced hepatocellular carcinoma (HCC) is the most frequent liver cancer. Immunotherapy has been explored in this disease in order to improve survival outcomes. Nowadays, scientific research is focusing especially on immune checkpoint inhibitors, in particular anti-PD1, anti-PD-L1 and anti-CTLA4 monoclonal antibodies (mAbs), as single-agent or in combination with other immunotherapy agents, target therapies, anti-vascular endothelial growth factor (VEGF) and other agents targeting specific molecular pathways.
View Article and Find Full Text PDFGraefes Arch Clin Exp Ophthalmol
April 2021
Department of Surgical Sciences, Eye Clinic, University of Cagliari, Via Ospedale 48, 09124, Cagliari, Italy.
Sci Rep
November 2020
San Giovanni di Dio Hospital, Clinica Oculistica, Azienda Ospedaliera Universitaria di Cagliari, via Ospedale 46, 09124, Cagliari, Italy.
The purpose of this study was to use a portable optical coherence tomography (OCT) for characterization of corneal stromal striae (CSS) in an ovine animal model and human corneas with histological correlation, in order to evaluate their architectural pattern by image analysis. Forty-six eyes from female adult sheep (older than 2 years), and 12 human corneas, were included in our study. The eyes were examined in situ by a portable OCT, without enucleation.
View Article and Find Full Text PDFSci Rep
September 2020
Department of Surgical Science, Eye Clinic, University of Cagliari, Via Ospedale 46, 09124, Cagliari, Italy.
To assess the repeatability and reproducibility of post-mortem central corneal thickness (CCT) measurements made by the portable iVue spectra-domain (SD) optical coherence tomography OCT (Optovue Inc, Fremont, CA) system in humans, and to prospectively establish the time-course of CCT after death. In a prospective multicenter setting, CCT measurements were obtained from 58 human eyes at the following 16 time-points after death: immediately (within 2 h), and at each hour by the next 17 h. The range of CCT values for each subject was determined and longitudinal data were used to illustrate the variation in open and close eye mode.
View Article and Find Full Text PDFBrain Connect
October 2020
Department of Radiology, Azienda Ospedaliera Universitaria di Cagliari, University of Cagliari, Cagliari, Italy.
To investigate the relationships between white matter hyperintensities (WMH) and hippocampal volume and their influence on brain networks by using resting-state functional connectivity (rs-fc) magnetic resonance (MR) according to their localization. In this exploratory cross-sectional study, 38 subjects from the public "Leipzig Study for Mind/Body/Emotion Interactions" (LEMON) data set were selected. Morphometric analyses of both WMH burden and the total hippocampal relative volume (tHRV) were performed for each subject with two automated software.
View Article and Find Full Text PDFJ Clin Med
July 2020
Clinica Oculistica, San Giovanni di Dio Hospital, Azienda Ospedaliera Universitaria di Cagliari, 09124 Cagliari, Italy.
The coronavirus disease 2019 (COVID-19) represents a global concern of public health caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its clinical manifestations are characterized by a heterogeneous group of symptoms and pictures (ranging from asymptomatic to lethal courses). The prevalence of conjunctivitis in patients with COVID-19 is at present controversial.
View Article and Find Full Text PDFJ Clin Med
May 2020
Department of Surgical Science, University of Cagliari, Eye Clinic, via Ospedale 46, 09124 Cagliari, Italy.
Ocular surgery is one of the most performed medical procedures in the world. Its limitation or suspension, recursively extended over time, could be associated with a significant increase in the number of blind people worldwide. Indeed, cataract causes more than half of all cases of visual impairment in those countries with limited availability of means for performing eye operations (e.
View Article and Find Full Text PDFJ Clin Med
April 2020
Department of Surgical Science, University of Cagliari, Eye Clinic, via Ospedale 46, 09124 Cagliari, Italy.
Coronavirus disease 2019 (COVID-19) is an important health problem that was defined as a pandemic by the World Health Organization on 11 March 2020. Although great concern has been expressed about COVID-19 infection acquired through ocular transmission, its underlying mechanism has not currently been clarified. In the current work, we analyzed and elucidated the two main elements that should be taken into account to understand the "ocular route", both from a clinical and molecular point of view.
View Article and Find Full Text PDFEur Radiol
September 2020
Department of Radiology, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
The original version of this article, published on 16 December 2019, unfortunately contained two mistakes.
View Article and Find Full Text PDFObjective: To investigate predictors of response, remission, low disease activity, damage, and drug discontinuation in patients with systemic lupus erythematosus (SLE) who were treated with belimumab.
Methods: In this retrospective study of a multicenter cohort of SLE patients who received intravenous belimumab, the proportion of patients who achieved remission, low disease activity, and treatment response according to the SLE Responder Index 4 (SRI-4) was determined, and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) was used to score disease damage yearly over the follow-up. Predictors of outcomes were analyzed by multivariate logistic regression with the results expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs).
Commun Biol
March 2020
Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
J Clin Med
March 2020
Clinica Oculistica, San Giovanni di Dio Hospital, Azienda Ospedaliera Universitaria di Cagliari, 09124 Cagliari, Italy.
In the last few decades, the ocular surface and the tear film have been noninvasively investigated in vivo, in a three-dimensional, high resolution, and real-time mode, by optical coherence tomography (OCT). Recently, OCT technology has made great strides in improving the acquisition speed and image resolution, thus increasing its impact in daily clinical practice and in the research setting. All these results have been achieved because of a transition from traditional time-domain (TD) to Fourier-domain (FD) technology.
View Article and Find Full Text PDFSci Rep
January 2020
Department of Biomolecular Sciences, Università degli Studi di Urbino "Carlo Bo", Urbino, Italy.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFTarget Oncol
February 2020
Department of Radiology, Azienda Ospedaliera Universitaria Di Cagliari, S.S: 554, km 4500, CAP: 09042, Monserrato, Cagliari, Italy.
The immunotherapy revolution in cancer treatment involves a variety of specialists, not only oncologists, but also internal medicine physicians, endocrinologists, dermatologists, gastroenterologists, rheumatologists, and radiologists, introducing new scenarios and novel challenges in the diagnosis and management of a number of novel immune-related adverse events. Among these, immune checkpoint inhibitor-induced pancreatic injury has been described (occurring in up to 4% of patients) and has been reported to be responsible for visits to the emergency departments in up to 1.9% of patients treated with immune checkpoint inhibitors.
View Article and Find Full Text PDFEur Radiol
April 2020
Department of Radiology, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Objective: To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study.
Materials And Methods: From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA.
Drug Des Devel Ther
June 2020
Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy.
Purpose: To evaluate the efficacy and safety of combined 25-gauge (G) pars plana vitrectomy (PPV) with intravitreal dexamethasone implant (DXI) for the treatment of advanced stage epiretinal membrane (ERM).
Methods: Forty consecutive pseudophakic eyes with idiopathic stage 3-4 ERM and intraretinal cysts were randomly assigned to two treatment groups. Twenty eyes underwent combined 25-G PPV, ERM peeling and slow-release DXI (DEX group), whereas 20 eyes underwent standard 25-G PPV with ERM peeling only (control group).
Sci Rep
August 2019
Department of Biomolecular Sciences, Università degli Studi di Urbino "Carlo Bo", Urbino, Italy.
Polymorphisms contribute to inter-individual differences and show a promising predictive role for chemotherapy-related toxicity in colon cancer (CC). TOSCA is a multicentre, randomized, non-inferiority, phase III study conducted in high-risk stage II/stage III CC patients treated with 6 vs 3 months of FOLFOX-4 or XELOX adjuvant chemotherapy. During this post-hoc analysis, 218 women and 294 men were genotyped for 17 polymorphisms: TYMS (rs34743033, rs2853542, rs11280056), MTHFR (rs1801133, rs1801131), ERCC1 (rs11615), XRCC1 (rs25487), XRCC3 (rs861539), XPD (rs1799793, rs13181), GSTP1 (rs1695), GSTT1/GSTM1 (deletion +/-), ABCC1 (rs2074087), and ABCC2 (rs3740066, rs1885301, rs4148386).
View Article and Find Full Text PDFDrug Des Devel Ther
February 2020
Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy.
Effective and tolerable therapeutic strategies for patients with refractory persistent epithelial defects (PEDs) are limited and generally provide poor outcomes. This retrospective case review describes four refractory cases of PEDs associated with recurrent corneal erosions (RCEs) and dry eye disease (DED), which were successfully treated with cyclosporine eye drops. Patients were treated with cyclosporine A 0.
View Article and Find Full Text PDFSci Rep
February 2019
From the San Giovanni di Dio hospital, Clinica Oculistica, Azienda Ospedaliera Universitaria di Cagliari, Cagliari, Italy.
The aim of the study was to define and characterize the optical behavior of the tear film during visual fixation in humans on en-face optical coherence tomography (OCT). We included 20 healthy participants, 60% female, aged from 25 to 42 years (33.05 ± 4.
View Article and Find Full Text PDFPLoS One
April 2019
Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy.
Purpose: To evaluate the feasibility of 3D anterior segment optical coherence tomography (AS-OCT) for the detection of corneal endothelial features in patients with Fuchs' Endothelial Corneal Dystrophy (FECD).
Methods: Twenty patients with clinical diagnosis of FECD (group A), and 20 control subjects (group B) were enrolled. In all patients a complete ophthalmological examination was performed, including best corrected visual acuity (BCVA), slit lamp examination for subjective grading of FECD and corneal endothelial specular microscopy.
Eur J Ophthalmol
September 2019
Department of Surgical Science, Eye Clinic, University of Cagliari, Cagliari, Italy.
Purpose: To report the evolution of optic disk noncalcified astrocytic hamartomas in a patient with retinitis pigmentosa throughout 8 years of follow-up.
Methods: Case report.
Results: A 42-year-old white man with a diagnosis of retinitis pigmentosa was referred to our medical retinal center for the first time in 2010, for the development of a new optic nerve head lesion in the right eye.