120 results match your criteria: "Azad University of Tehran[Affiliation]"

Functionalized terahertz plasmonic metasensors: Femtomolar-level detection of SARS-CoV-2 spike proteins.

Biosens Bioelectron

April 2021

Faculty of Electrical & Computer Engineering, Science and Research Branch, Islamic Azad University of Tehran, Tehran, Iran; Department of Electrical Engineering, Varamin (Pishva) Branch Islamic Azad University, Varamin, Iran.

Effective and efficient management of human betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 virus infection i.e., COVID-19 pandemic, required sensitive and selective sensors with short sample-to-result durations for performing desired diagnostics.

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Pregnancy complications including preeclampsia, preterm birth, intrauterine growth restriction, and gestational diabetes are the main adverse reproductive outcomes. Excessive inflammation and oxidative stress play crucial roles in the pathogenesis of pregnancy disorders. Curcumin, the main polyphenolic compound derived from Curcuma longa, is mainly known by its anti-inflammatory and antioxidant properties.

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Transformational management properties could make the weakest organizations strong with the right and efficient approach build. The aim of this study was to determine the transformational management properties among hospital managers in Gonbad-e-Kavus. In terms of data collection, the present study is an an applied research involving objective and descriptive-analytical surveys.

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In December 2019, a novel coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or (2019-nCoV) with unknown origin spread in Hubei province of China. The epidemic disease caused by SARS-CoV-2 called coronavirus disease-19 (COVID-19). The presence of COVID-19 was manifested by several symptoms, ranging from asymptomatic/mild symptoms to severe illness and death.

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Background: Acne vulgaris is a common complication that patients referred to dermatologist, also there are medications to manage of this such as isotretinoin, and incidence of low back pain in these patients is more than general population, so in this study we aimed to evaluate of Incidence of low back pain and sacroiliitis in military families with acne vulgaris under isotretinoin therapy.

Methods: This cross-sectional study was performed on 113 acne vulgaris patients treated with isotretinoin (at least 3 months) referred to dermatology clinic of Imam Reza Hospital of Army Medical Sciences, Tehran, Iran during 2018 to 2019. All data of patients such as dosage and duration of medication, severity of acne, incidence of low back pain, sacroiliitis and inflammatory back pain and lab data were recorded.

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Background: Adherence to rehabilitation regimens is a major issue in the treatment of stroke. Despite the agreement on the importance of adherence, there is still no clear definition of this concept in rehabilitation. The aim of this study was the concept analysis of the concept of adherence to rehabilitation regimens in stroke patients.

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Background: This study aimed to investigate the effects of curcumin supplementation alone and in combination with aerobic training on body composition, glycemic variables, serum levels of C-reactive protein (CRP) and lipid profiles in overweight women.

Methods: In this randomized, double-blind, placebo-controlled trial, 40 healthy sedentary overweight females (aged 30-45 years with body mass index [BMI] of 25-30 kg/m) were randomly assigned to four groups of 10 subjects each: curcumin supplementation (Cur), placebo (Pla), placebo+aerobic training (Pla+Tra), curcumin supplementation+aerobic training (Cur+Tra). Curcumin or placebo capsules (500 mg/day) were administered for 8 weeks.

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Adherence to rehabilitation has significant effects on patient outcomes. This study aimed to explore factors affecting adherence to rehabilitation in Iranian stroke patients. This is a descriptive, qualitative study.

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An insight of microRNAs performance in carcinogenesis and tumorigenesis; an overview of cancer therapy.

Life Sci

January 2020

Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran. Electronic address:

Importance of dysregulation and expression of microRNAs (miRNAs) has been confiemed in many disorders comprising cancer. In this way, different approaches to induce reprogramming from one cell type to another in oerder to control the cell normal mechanisem, comprising microRNAs, combinatorial small molecules, exosome-mediated reprogramming, embryonic microenvironment and also lineage-specific transcription agents, are involved in cell situation. Meaningly, besides the above factors, microRNAs are so special and have an impressive role in cell reprogramming.

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Background: Calcitriol, the active metabolite of vitamin D, is an essential regulator in the hematopoiesis and immunity. However, knowledge revealing its influence on the immune and hematologic reconstitution after hematopoietic stem cell transplantation (HSCT) in clinical trials is very limited.

Objectives: The effects of calcitriol on short-term and long-term hematopoietic recovery, relapse-free survival (RFS) and overall survival (OS) in multiple myeloma, Hodgkin's and non-Hodgkin's lymphoma following autologous peripheral blood HSCT were assessed.

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Glatiramer acetate attenuates renal ischemia reperfusion injury in rat model.

Exp Mol Pathol

February 2020

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, P.O. Box 13145-784, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, P.O. Box 13145-784, Iran. Electronic address:

Chronic renal failure can ultimately lead to kidney transplantation. Renal transplantation is associated with ischemia-reperfusion injury (I/R). The subsequent processes of kidney I/R can lead to irreversible damages to the kidney tissue.

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Background: Holistic care addresses the physical, psychological, social, and spiritual dimensions of the patient in which spiritual dimension plays a pivotal role in patient care.

Objective: The objective of this study is to investigate the association between spiritual intelligence with stress, anxiety, and depression coping styles in patients with cancer.

Methods: This analytic descriptive study was carried out on 276 patients with cancer receiving chemotherapy in university hospitals of Tehran University of Medical Sciences during 2013-2014.

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Background: Attending to psychological status in patients with breast cancer, because of expanded damage and mortality in these patients, is important. The present study investigated the effectiveness of Solution-Focused Brief Therapy (SFBT) on depression and Perceived Stress in Patients with breast cancer.

Materials And Methods: This research was a semi-experimental with pretest, post-test and follow-up (1 month), which was conducted from November to February, 2016.

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Background: Glutathione S-transferases (GSTs) polymorphisms may impact on chronic myeloid leukemia (CML) risk or heterogeneous responses to Imatinib mesylate (IM). The aim of this study was to evaluate the correlation between GSTs polymorphisms and CML risk, treatment response.

Methods: We genotyped GSTM1, GSTT1 null deletion polymorphisms, and GSTP1 Ile105Val polymorphism by PCR methods and BCR-ABL transcripts were analyzed by qRT-PCR in 104 CML patients and 104 sex- and age-matched healthy individuals.

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Background: This study aimed to determine the long-term survival rate of implants placed in fresh sockets of extracted maxillary molars with simultaneous sinus floor elevation and early loading protocol.

Methods: Nineteen maxillary molar teeth were extracted by tooth sectioning, and the sockets were debrided. Drilling for implant placement (Either Xive, Dentsply or Axiom, Antogyr) was terminated 1 mm short of the sinus floor with a pilot drill.

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Drought tolerance is an important quantitative trait with multipart phenotypes that are often further complicated by plant phenology. Different types of environmental stresses, such as high irradiance, high temperatures, nutrient deficiencies, and toxicities, may challenge crops simultaneously; therefore, breeding for drought tolerance is very complicated. Interdisciplinary researchers have been attempting to dissect and comprehend the mechanisms of plant tolerance to drought stress using various methods; however, the limited success of molecular breeding and physiological approaches suggests that we rethink our strategies.

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Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity.

Nanomaterials (Basel)

August 2018

Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University in Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.

Nanoparticles (NPs) are currently used in diagnosis and treatment of many human diseases, including autoimmune diseases and cancer. However, cytotoxic effects of NPs on normal cells and living organs is a severe limiting factor that hinders their use in clinic. In addition, diversity of NPs and their physico-chemical properties, including particle size, shape, surface area, dispersity and protein corona effects are considered as key factors that have a crucial impact on their safe or toxicological behaviors.

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The goal of the current study was to evaluate the efficiency of a phytotherapeutic intervention consisting of a combination of Nigella sativa and Vitex agnus-castus with citalopram in the control of hot flashes in healthy menopausal women. An 8 week, double-blind, randomized, placebo-controlled study was performed among 46 women aged between 40 and 60 years experiencing an average of more than four hot flashes per day recruited during July 2016 to June 2017. Data on severity of vasomotor symptoms were collected at the end of the eighth week.

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Cobalt oxide nanoparticles mediate tau denaturation and cytotoxicity against PC-12 cell line.

Int J Biol Macromol

October 2018

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University of Tehran (IAUPS), Iran. Electronic address:

It has not been well explored how NPs may induce some adverse effects on the biological systems. In this research, the interaction of cobalt oxide NPs (CoO NPs) with tau protein and PC-12 cell line, as nervous system models, was investigated with several approaches including fluorescence spectroscopy, CD spectroscopy, docking study, MTT, LDH, AO/EB dual staining, and flow cytometry assays. Fluorescence investigation displayed that CoO NPs spontaneously mediate the formation of a static complex with tau protein through hydrogen bonds and van der Waals forces.

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There is evidence that rural versus urban residence is a salient factor in predicting parenting practices. In what is most likely the very first video-observation study of parenting ever to come out of Iran, mothers and their 18-60-month-old children were observed for 30 min of free interaction at their homes in urban (n = 11) and rural (n = 15) Iran. None of the mothers made any comments about being filmed, none expressed insecurities about what to do, and only four mothers looked at the camera more than once or twice.

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Human exposure to nanoparticles (NPs) is inevitable as NPs become more widely applied and, as a result, nanotoxicology study is now gaining attention. Herein, the interaction of zero valent iron NPs (ZVFe-NPs) with human hemoglobin (Hb) was evaluated using a variety of techniques including fluorescence spectroscopy, far circular dichroism (CD) spectroscopy as well as docking study. Also, the cytotoxicity of ZVFe-NPs on the human lymphocyte cell line as a model of blood system cell line was investigated by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), acridine orange/ethidium bromide (AO/EB) staining, flow cytometry, and real-time PCR assays.

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Positron Emission Tomography (PET) is often underutilized in the field of musculoskeletal imaging, with key reasons including the excellent performance of conventional musculoskeletal MRI, the limited spatial resolution of PET, and the lack of reimbursement for PET for non-oncologic musculoskeletal indications. However, with improvements in PET/CT and PET/MR imaging over the last decade as well as an increased understanding of the pathophysiology of musculoskeletal diseases, there is an emerging potential for PET as a primary or complementary modality in the management of rheumatologic and orthopedic patients. Specific advantages of PET include the convenience of whole body imaging in a single session, the relative resilience of the modality in the imaging of metallic implants compared to CT and MRI, the ability to evaluate deep joints not amenable to palpation, and the potential for improved specificity of diagnosis with novel radiopharmaceuticals.

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Temporomandibular joint disorders (TMDs) usually present with symptoms and signs such as pain, mandibular movement, dysfunction, or joint sounds. Botulinum toxin type A (BTX-A) is a biologic toxin which inhibits skeletal muscle through hindering the production of acetylcholine in the nerve endings. This toxin is used for the treatment of hyperactivity of lateral pterygoid muscle and TMD symptoms.

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In the original publication of the article, the affiliation of the third author has been incorrectly published as University of Yazd. However, the correct affiliation is Yazd University.

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