Effects of Amino Acid Supplementation on the Growth Performance of Broiler Chicks Challenged With Coccidiosis: A Meta-Analysis.

This meta-analysis aimed to evaluate the effects of amino acid supplementation on the growth performance of broiler chicks challenged with coccidiosis. Data were collected on authorship, publication year, study sample characteristics and outcomes of interest related to growth performance. Effect sizes were calculated for both overall effects and the individual effects of each amino acid.

Network-based meta-analysis and confirmation of genes ATP1A2, FXYD1, and ADCY3 associated with cAMP signaling in breast tumors compared to corresponding normal marginal tissues.

Breast cancer (BC) is a global health concern with a growing prevalence. Since BC is a heterogeneous cancer, transcriptome analyzes were carried out on breast tumor tissues relative to their corresponding normal tissues in order to identify gene expression signatures and perform meta-analysis. Five expression profiling by array data sets from breast tumor tissues and non-tumor neighboring tissues were retrieved following a search in the GEO database (GSE70947, GSE70905, GSE10780, GSE29044, and GSE42568).

Unraveling the impacts of progressive drought stress on the photosynthetic light reaction of tomato: assessed by chlorophyll-a fluorescence and gene expression analysis.

The present study aimed to investigate the impact of progressive drought stress (100%, 75%, 50%, and 25% of field capacity) on photosynthetic light reactions of tomato plants. The imposed drought caused a gradual reduction in leaf RWC leading to a decline in pigment concentration and growth indices.  Significant alteration in the OJIP fluorescence transient curves and the formation of specific fluorescence bands (L, K, J, H, and G) gradually increased as drought severity increased.

Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches.

MicroRNAs (miRNAs) emerge as critical regulators of CD8 + T cell function within the complex tumor microenvironment (TME). This review explores the multifaceted interplay between miRNAs and CD8 + T cells across various cancers. We discuss how specific miRNAs influence CD8 + T cell activation, recruitment, infiltration, and effector function.

Translation and psychometric properties of the comfort behavioral scale-Persian version.

Background: Managing pain and the level of sedation of critically ill children admitted to the intensive care unit is a complex process and one of the most basic problems of nurses, which requires the use of an available valid, and reliable scale. The present study aimed to translate the comfort behavioral scale into Persian and check its validity and reliability.

Methods: This methodological research was carried out in the children's hospitals of Tehran Province (Iran) from Nov 2023 to Apr 2024.

Telomerase-based vaccines: a promising frontier in cancer immunotherapy.

Telomerase, an enzyme crucial for maintaining telomere length, plays a critical role in cellular immortality and is overexpressed in most cancers. This ubiquitous presence makes telomerase, and specifically its catalytic subunit, human telomerase reverse transcriptase (hTERT), an attractive target for cancer immunotherapy. This review explores the development and application of telomerase-based vaccines, focusing on DNA and peptide-based approaches.

Violence against infertile women in an Iranian setting.

Background: Infertility as a distressing condition, is associated with numerous psychological and social consequences for couples. In addition, there is evidence to suggest that infertility may contribute to the occurrence of violence against women. The aim of the study is to determine the prevalence and factors associated with violence against Iranian women with infertility.

Prognostic value of anion gap for patients with heart failure: a systematic review and meta-analysis.

Background: Heart failure (HF) is among the cardiovascular diseases with high morbidity and mortality worldwide. Due to the high burden of HF, finding easy-to-use prognostic factors has become important. Studies have investigated the correlation between anion gap (AG) and the HF prognosis.

Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents-challenges and limitations.

Globally, people widely recognize cancer as one of the most lethal diseases due to its high mortality rates and lack of effective treatment options. Ongoing research into cancer therapies remains a critical area of inquiry, holding significant social relevance. Currently used treatment, such as chemotherapy, radiation, or surgery, often suffers from other problems like damaging side effects, inaccuracy, and the lack of ability to clear tumors.

In vitro and in vivo study of the antifungal activity of extracellular products of cyanobacterium Neowestiellopsis persica strain A1387 against Fusarium wilt disease of cucumber.

Fusarium wilt of cucumber, caused by the fungus Fusarium oxysporum, is a major plant disease that causes significant economic losses. The extensive use of chemical fungicides for its control poses environmental and health risks. Due to growing concerns about the detrimental effects of chemical fungicides, finding safe and effective bio-based alternatives for plant disease control is of high importance.

The role of probiotics in restoring the Th1 to Th2 ratio in women experiencing recurrent implantation failure; a double-blind randomized clinical trial.

Background: Among the complex causes of infertility, Recurrent Implantation Failure (RIF) stands out as a challenging condition. Immunological aberrations are closely implicated in RIF, particularly the imbalance between T helper 1 (Th1) and T helper 2 (Th2) cytokines. Interest in harnessing probiotics to enhance fertility outcomes in RIF-affected women is growing.

Membrane vesicles from lactobacillus acidophilus reduce intestinal inflammation and increase 5-HT in the substantia nigra of rats with parkinson's disease.

Background: This study aimed to investigate the role of membrane vesicles (MVs) from the probiotic Lactobacillus acidophilus in reducing intestinal inflammation and increasing 5-hydroxytryptamine (5-HT) and tyrosine hydroxylase (TH) in the substantia nigra in the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD).

Methods: Twenty healthy male Wistar rats were randomly assigned to four groups (n = 5 per group), including a) control, b) 6-OHDA, c) 6-OHDA+MV, and d) sham groups. PD was induced by bilateral injection of 6-OHDA.

Presentation, management, and outcome of traumatic spine injuries in Africa: a systematic review and meta-analysis.

Objective: Traumatic spinal injury (TSI) involves diverse etiologies, posing different risks among patient populations worldwide. Discrepancies in TSI treatment and outcomes between high-income countries and low- and middle-income countries highlight the critical necessity for tailored management approaches for this global challenge. This study delves into the presentation, management, and outcomes of TSI in Africa.

Zinc oxide fabricated by rutin as potent anti-leukemia nanostructure.

Treatment of chronic myeloid leukemia (CML) is a significant therapeutic challenge, and exploration of novel treatment approaches is an urgent necessity. This work investigates the anticancer properties of rutin-conjugated zinc oxide nanoparticles (Rut-ZnO NPs) against CML cells. Physicochemical properties of the NPs were studied by FT-IR, FE-SEM, XRD, zeta potential, and DLS analyses.

A novel inhibitory strategy of using and killer toxins.

Aim: Leishmaniasis is a globally prevalent parasitic disease that has drawn significant attention. Killer yeasts offer a novel biological control method, presenting a potential alternative for treating leishmaniasis. This study evaluates the antileishmanial activity of and killer toxins against .

Relationship between workplace violence and attitudes towards the nursing profession in nursing students: A cross-sectional study in Iran.

Background: Nursing students are at risk of violence. When nursing students encounter violence in clinical environments, their functional abilities and their desire to stay in this profession are impressed. This research determines the relationship between violence in the workplace and the attitude towards the nursing profession (NP) among Iranian nursing students in 2021.

Effectiveness of cognitive-behavioral therapy on mental health, life expectancy, and happiness in patients receiving methadone maintenance treatment.

Background: Nowadays, the issue of substance abuse is one of the major problems facing most countries in the world. The present study aimed to evaluate the effectiveness of cognitive-behavioral therapy (CBT) on mental health, life expectancy, and happiness in patients receiving methadone maintenance treatment (MMT).

Materials And Methods: The present study was performed from February 2021 to January 2022.

Up-Regulation of miR-625-5p Correlates with Suppressed Sox2, Increased Apoptosis, and Cell Cycle Arrest via The PI3K/AKT Signalling Pathway in Acute Myeloid Leukaemia.

Up-regulation of the microRNA-625 and abnormal expression of the Sox2 gene have been studied and seen in several tumors. Few reports have also shown the aberrant expression of miR-625 and Sox2 expression in various cancers. Several studies have also confirmed that phosphatidylinositol 3' -kinase /protein kinase B pathways regulate hematological malignancies, including Acute Myeloid Leukemia (AML).

Prevalence and Phylogenetic Analysis of Rhinoviruses in Patients with Acute Respiratory Infections and Community-Acquired Pneumonia in a Referral Hospital, Tehran, Iran.

Background: Rhinoviruses are known as the leading pathogens of respiratory diseases. Determining the prevalence and phylogeny of rhinoviruses plays a pivotal role in producing vaccines and medications and preventing virus complications. This study investigated the frequency, and genetic variation of rhinoviruses detected in patients referred to Masih Daneshvari Hospital.

Extensive Left Ventricular Thrombosis after Recovery from COVID-19: A Case Report.

Coagulation disorder is common among COVID-19 patients, particularly those afflicted with the severe form of the disease. Manifestations of thrombotic complications such as pulmonary embolism, deep vein thrombosis (DVT), ischemic stroke, cardiac infarction and arterial embolism is high in COVID-19 patients which have been assessed in various studies (5).It seems that COVID-19-related coagulopathy is a combination of low-grade DIC and pulmonary thrombotic microangiopathy which can have a significant effect on organ dysfunction in patients with severe COVID-19 (6).

Physiological Responses to Facemask Use during a Graded Treadmill Test in Healthy Male Adolescents and Young.

Background: we aimed to investigate the physiological impact of facemasks use during a graded treadmill exercise test in male adolescents and young adults.

Materials And Methods: Twenty-one males aged 15 to 28 volunteered. Participants completed four sessions with a 72-hour gap between each session.

Expression of miR-155 and CEA and VEGF Proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer in Peripheral Blood.

Background: Cancer is a disease caused by manifestation and abnormal gene expression. Many of the genes that inhibit cancer by the microRNAs. The aim of this study was to investigate the Expression of miR155 gene and CEA and VEGF proteins as Diagnostic Markers in Early Stages of Non-Small Cell Lung Cancer (NSCLC).