2,454 results match your criteria: "Azabu University; Kanagawa 229-8501[Affiliation]"

In this study, we investigated whether monitoring the ventral tail base surface temperature (ST) using a wearable wireless sensor could be effective for fever detection in calves with experimentally induced pneumonia after inoculation with Histophilus somni strain 2336. We found a significant difference in the changes in ST values between the control and H. somni-inoculated groups after 24 h of inoculation and detected fever; however, the rectal temperature showed a significant difference between the groups after 12 h of inoculation.

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Regulatory mechanisms underlying interleukin-6 expression in murine brown adipocytes.

Cell Biochem Funct

January 2024

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.

Three types of adipocytes, white, brown, and beige, regulate the systemic energy balance through the storage and expenditure of chemical energy. In addition, adipocytes produce various bioactive molecules known as adipokines. In contrast to white adipocyte-derived molecules, less information is available on the adipokines produced by brown adipocytes (batokine).

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Article Synopsis
  • The study investigated the long-term relationship between mitochondrial DNA copy number (mtDNA-CN) in leukocytes and the risk of all-cause mortality in a Japanese population over roughly 30 years.
  • It involved 814 participants aged between 38 to 80 years and measured mtDNA-CN using blood samples, categorizing levels into low, middle, and high.
  • Results indicated that low mtDNA-CN levels significantly reduced survival rates, particularly in the middle-aged group, highlighting its potential as a predictor for future mortality risk.
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Some reports have been published on clinical features in dogs with early recurrence of type I thoracolumbar intervertebral disk herniation (TL-IVDH), but there is little understanding of the changes involved. This retrospective study describes the clinical features, including radiographic image results at the time of recurrence, of dogs with type I TL-IVDH that had undergone hemilaminectomy but then suffered early recurrence. Our medical records were searched between June 2007 and December 2022.

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The matrilineal transmission of maternal behavior has been reported in several species. Studies, primarily on rats, have suggested the importance of postnatal experience and the involvement of epigenetic mechanisms in mediating these transmissions. This study aims to determine whether the matrilineal transmission of maternal behavior occurs in mice and whether the microbiota is involved.

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Breed-Specific Skull Morphology Reveals Insights into Canine Optic Chiasm Positioning and Orbital Structure through 3D CT Scan Analysis.

Animals (Basel)

January 2024

Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, 35-1 Higashi 23 Ban-Cho, Towada 034-8628, Aomori, Japan.

Article Synopsis
  • The study analyzed skull shape variations in 50 adult dogs, categorizing them into brachycephalic, mesocephalic, and dolichocephalic types based on skull index (SI).
  • Significant differences were found in skull and facial lengths, with brachycephalic dogs having shorter measurements, as well as shorter orbital depths compared to other types.
  • The study concluded that the optic canal angles and zygomatic bone structure play crucial roles in breed-specific orbital variations, linking facial structure to the base of the skull.
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Brain Temperature as an Indicator of Cognitive Function in Traumatic Brain Injury Patients.

Metabolites

December 2023

Laboratory for Biomarker Imaging Science, Graduate School of Biomedical Science and Engineering, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-8638, Japan.

Whether brain temperature noninvasively extracted by magnetic resonance imaging has a role in identifying brain changes in the later phases of mild to moderate traumatic brain injury (TBI) is not known. This prospective study aimed to evaluate if TBI patients in subacute and chronic phases had altered brain temperature measured by whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) and if the measurable brain temperature had any relationship with cognitive function scores. WB-MRSI was performed on eight TBI patients and fifteen age- and sex-matched control subjects.

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Oral squamous cell carcinoma (oSCC) is a highly invasive malignant neoplasm in cats. Recently, tumor stroma, known as tumor microenvironments, have been considered to play an essential role in tumor progression. However, their role in feline squamous cell carcinoma (SCC) remains unclear.

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Pulmonary aspergillosis occurring in captive penguins living in zoos and aquariums is a fatal disease owing to its high mortality rate. On conducting computed tomography, two gentoo penguins (Pygoscelis papua) with respiratory clinical signs that were housed at an aquarium in Hokkaido, Japan were found to have a certain amount of fluid in their air sacs. This fluid was collected and cultured for bacteria and fungi, the results of which both came back negative.

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In a windowless poultry house raising layer chickens in Kanagawa prefecture, Japan, a slight increase in the mortality of chickens and a decrease in egg production were observed. Necropsy revealed numerous tapeworms and proglottids in chicken intestines. Histopathologically, gut-associated lymphoid tissues were observed in the lamina propria of the jejunum; however, no significant changes were observed in the other organs.

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Curing produces a characteristic pink color during meat processing through the production of nitrosyl myoglobin (NOMb), which requires nitric oxide (NO). Nitrites and nitrates in coloring agents are crucial NO sources; however, a reducing agent is necessary to facilitate their chemical conversion to NO. This study aimed to investigate the effect of the reducing properties of whey protein hydrolysate (WPH) on the reddening of cured meat products.

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Characterization of a nuclear transport factor 2-like domain-containing protein in Plasmodium berghei.

Malar J

January 2024

Department of Environmental Science, School of Life and Environmental Science, Azabu University, Kanagawa, 252-5201, Japan.

Article Synopsis
  • * Researchers created a deletion mutant (Δ1019700) to assess its impact on parasite growth and virulence, finding that PBANKA_1019700 deletion affects the sexual reproductive phase of the parasite but does not impact the asexual phase.
  • * Live-cell imaging and mass spectrometry revealed that PBANKA_1019700 is cytoplasmic and interacts with ubiquitin-related proteins, suggesting its role in mRNA export is distinct from that of traditional nuclear proteins. *
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Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice.

Sci Rep

January 2024

Laboratory of Food Function and Safety, Department of Animal Science, School of Veterinary Medicine, Kitasato University, Towada, Japan.

Skeletal muscle is one of the largest metabolic tissues in mammals and is composed of four different types of muscle fibers (types 1, 2A, 2X, and 2B); however, type 2B is absent in humans. Given that slow-twitch fibers are superior to fast-twitch fibers in terms of oxidative metabolism and are rich in mitochondria, shift of muscle fiber types in direction towards slower fiber types improves metabolic disorders and endurance capacity. We previously had reported that oleic acid supplementation increases type 1 fiber formation in C2C12 myotubes; however, its function still remains unclear.

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Article Synopsis
  • The Japanese food composition database was updated in 2020, expanding the variety and measurements of sugars, amino acids, and fatty acids, prompting a validation study using a food frequency questionnaire (long-FFQ).
  • A study involving 240 participants aged 40-74 compared the long-FFQ with a 12-day weighed food record, assessing validity through Spearman's correlation coefficients.
  • The long-FFQ showed reasonable validity in estimating nutrient intakes, particularly sugars, amino acids, and fatty acids, but highlighted the need for caution with certain nutrients, making it a useful tool for future studies.
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Analysis of Alternative Methods of Environmental Monitoring for Listeria in Food Production Facilities.

J Food Prot

February 2024

School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.

Validated alternative test methodologies may be used in place of culture-based methods recommended for environmental monitoring programs (EMPs) for Listeria in food production facilities. In order to help guide decisions on which testing method to use to simplify Listeria EMP implementation in food production facilities, alternative methods were compared to the culture-based method in actual EMPs for Listeria. Seventy-two samples collected from two facilities of souzai production businesses that use meat and meat products as ingredients, one facility of processed meat product production business, and one facility of processed meat product and souzai production business were applied to EMPs for Listeria using the culture-based method, 3M Molecular Detection System (MDS), and InSite L.

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Article Synopsis
  • Building friendly relationships is key for good mental health, and robots may help in this area, though evidence is limited.
  • Studies showed that people who own companion robots had higher levels of oxytocin and displayed more intimate behaviors compared to those without robots.
  • Interaction with robots, even for just 15 minutes, lowered stress hormone cortisol in both groups, indicating that robot relationships can positively impact mental health.
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Objective: To establish a threshold value of bovine leukemia virus (BLV) proviral load (PVL) to identify increased risk of severe clinical mastitis, and to examine the prognosis and economic loss of clinical mastitis based on the newly established PVL cut-off value.

Animals: 97 lactating Holstein cows with clinical mastitis.

Methods: Blood and milk samples were collected aseptically from each cow.

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Effects of the Calls and Presence of Roosters on Egg Incubation Behavior of Nagoya Laying Hens.

J Poult Sci

December 2023

Laboratory of Animal Genetics and Breeding, Azabu University, Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa 252-5201, Japan.

The incubation behavior of the Japanese Nagoya chicken breed is a commercial issue because it often causes a sudden and sharp drop in egg production. In this study, whether the incidence of incubation behavior in Nagoya laying hens was associated with calls and the presence of roosters in the same laying house was investigated. Four experiments were conducted using commercial layer-type Nagoya hens where the hatching time of the experimental birds and the treatment order in the presence of males were changed .

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Cutaneous anaphylactoid reaction to polyoxyethylene hydrogenated castor oil in dogs.

Vet Dermatol

June 2024

Laboratory of Veterinary Radiology, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.

Background: Polyoxyethylene hydrogenated castor oil (HCO ethoxylates) is a nonionic surfactant used as an excipient for ointments and injections in human and veterinary drugs. Several polyethylene glycol (PEG) derivatives can be obtained depending on the number of moles of ethylene oxide (EO). HCO ethoxylates have the potential to cause anaphylactoid reactions.

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Focal segmental glomerulosclerosis, characterized by decreased numbers of podocytes in glomeruli, is a common cause of refractory nephrotic syndrome. Recently, we showed that enhanced glycosphingolipid GM3 expression after administration of valproic acid, an upregulator of ST3GAL5/St3gal5, was effective in preventing albuminuria and podocyte injury. We also revealed the molecular mechanism for this preventive effect, which involves GM3 directly binding nephrin that then act together in glycolipid-enriched membrane (GEM) fractions under normal conditions and in non-GEM fractions under nephrin injury conditions.

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Several hundred disease-causing mutations are currently known in domestic dogs. Breeding management is therefore required to minimize their spread. Recently, genetic methods such as direct-to-consumer testing have gained popularity; however, their effects on dog populations are unclear.

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First report of the whole-genome sequence analysis of avian rotavirus A from Japanese chickens.

Virus Genes

February 2024

Laboratory of Veterinary Infectious Diseases, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-8509, Japan.

Article Synopsis
  • Rotavirus A is a virus that causes gastrointestinal diseases in many mammals, including humans and birds like chickens, but there is limited information on its impact on chicken populations in Japan.
  • This study presents the first complete genome analysis of avian rotavirus A strains found in Japanese chickens, revealing specific genetic characteristics and their relationship to other strains.
  • The genetic analysis indicates that the Japanese ARVA strains are genetically closer to Korean strains than to European ones, but more research is needed to understand their origins and relationships fully.
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A feline spinal dermoid cyst treated with surgical intervention.

J Vet Med Sci

January 2024

Laboratory of Veterinary Surgery, Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka, Japan.

A 5-year-old neutered female mixed cat presented with reduced activity and ataxia of the hind limbs. Computed tomography and magnetic resonance imaging revealed an extradural mass compressing the spinal cord on the dorsal aspects from the 7th to 8th thoracic vertebra. Dorsal laminectomy was performed on the 7-8th thoracic vertebra and the cyst was totally removed, giving full resolution of the clinical signs.

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Influence of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) on Glycolytic Metabolism of Canine Glioma: A Potential Improvement in Cancer Metabolism.

Cancers (Basel)

November 2023

Laboratory of Veterinary Surgery, Graduate School of Life and Environmental Sciences, Osaka Metropolitan University, 1-58 Rinku-Oraikita, Izumisano 598-8531, Japan.

Article Synopsis
  • HIF-1α drives glycolysis in gliomas under low oxygen, supporting tumor growth and indicating higher risks of poor outcomes in affected dogs.
  • Evofosfamide (EVO) targets hypoxic tumor regions and shows promise as a treatment by inhibiting glycolytic metabolism in cancer cells.
  • Preclinical studies reveal that EVO reduces tumor development and alters cancer metabolism by eliminating HIF-1α-positive cells, which may benefit treatment strategies for canine gliomas.
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Aims: The developmental origin of health and disease (DOHaD) theory postulates that poor nutrition during fetal life increases the risk of disease later in life. Excessive fructose intake has been associated with obesity, diabetes, and nonalcoholic fatty liver disease, and maternal fructose intake during pregnancy has been shown to affect offspring health. In this study, we investigated the effects of high maternal fructose intake on the liver stem/progenitor cells of offspring.

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