Microgels of N-Isopropylacrylamide Copolymerized with an Amphiphilic Acid for the Delivery of Doxorubicin.

This study aims to design microgels that are thermo- and pH-sensitive for controlled doxorubicin (Dox) release in response to tumor microenvironment changes. N-isopropylacrylamide (NIPAAm) is widely used for thermoresponsive tumor-targeted drug delivery systems for the release of therapeutic payloads in response to temperature changes. Herein, a NIPAAm microgel (MP) that is responsive to temperature and pH was designed for the smart delivery of Dox.

Circadian Regulation of Fatty Acid Metabolism in Humans: Is There Evidence of an Optimal Time Window for Maximizing Fat Oxidation During Exercise?

Exercise training performed at the intensity that elicits maximal fat oxidation improves cardiovascular function and metabolic health while simultaneously reducing visceral adipose tissue in patients with obesity and type 2 diabetes. Indeed, it is currently considered an efficient non-pharmacological approach for the prevention and treatment of cardiometabolic disorders. Over the last 5 years, several studies have reported a diurnal variation in both resting fat oxidation as well as maximal fat oxidation recorded during submaximal intensity exercise.

Fabrication and evaluation of a sensitive electrochemical sensor based on double hydroxide in nickel-aluminum nanolayers for the quantification of pyrocatechol.

Pyrocatechol, also known as catechol, is a commonly used compound in various industries; however, it can be toxic when used in high concentrations. Therefore, developing a highly sensitive electrochemical sensor for detecting pyrocatechol is important. Our study utilized a co-precipitation technique to fabricate a nanostructured nickel aluminum layered double hydroxide (Ni-Al-LDH).

Analysing the gene expression profiles of the orphan nuclear receptors NR4A1, NR4A2 and NR4A3 in premalignant lesions of the cervix and cervicitis.

Objective: The main objective of the present study was to evaluate the expression of nuclear orphan receptors in the development of Uterine Cervical Cancer (UCC). The principal cause of dysplastic changes in cervical epithelium is the presence of the human papilloma virus leading to the development of cervical intraepithelial neoplasia I (CIN I), high-grade lesions (CIN II and CIN III) and, finally, invasive cancer. Despite the existence of various treatments and vaccines, there is still a high mortality rate.

Effect of Genotype on the Response to Diet in Cardiovascular Disease-A Scoping Review.

Background/objectives: Nutrigenetics investigates the role of genetic variants that contribute to the inter-individual variation in response to food intake. Risk factors for cardiovascular disease (CVD) are influenced by the complex interplay of genetic and environmental factors, including the diet. The aim of this scoping review is to analyze the literature on the effect of genotypes on the response to dietary interventions for the treatment of CVD risk factors.

Impact of Exercise Training at Maximal Fat Oxidation Intensity on Metabolic and Epigenetic Parameters in Patients with Overweight and Obesity: Study Protocol of a Randomized Controlled Trial.

Exercise is an essential pillar for human health, as it contributes to physical, mental, and emotional well-being. Well-recognized international organizations, such as the World Health Organization, advocate for integrating exercise into healthy lifestyles, recognizing its importance in disease prevention and improving quality of life. However, despite the consensus on its value, there is no universal agreement on specific prescriptions for vulnerable groups, highlighting the need for personalized approaches that consider the unique characteristics and needs of everyone.

Application of some cationic pullulan and curdlan derivatives as flocculants in fungicides-containing wastewater purification.

The ability of some cationic pullulan (TMAP-P) and curdlan (TMAP-C) derivative to remove different fungicide particles from synthetic wastewater has been studied. Commercial fungicides formulations of different type, Bordeaux mixture (BM), Dithan M45 (Dt) and Melody Compact49 WG (MC) have been used. The influence of some parameters related to the dispersion characteristics (suspension pH and salinity) and the polysaccharide derivatives (polymer dose, the ionic groups content, flexibility) on the separation process have been assessed.

Interaction of CETP rs708272 Polymorphism on Trans Fatty Acid Intake and Glucose Metabolism Markers.

Dietary fats influence gene expression and several metabolic pathways. Therefore, it is crucial to study the role of personal genotypes in the interaction between fat consumption and cardiometabolic markers. This research aimed to determine the interaction of the rs708272 polymorphism of and the fatty acid intake with changes in the HOMA-IR in adults living with overweight or obesity.

Comparison of Metabolic Syndrome, Autoimmune and Viral Distinctive Inflammatory Related Conditions as Affected by Body Mass Index.

: Metabolic inflammation (MI), long COVID (LC) and systemic lupus erythematosus (SLE) share some metabolic common manifestations and inflammatory pathophysiological similarities. Health-related quality of life (HRQoL) and metabolic age are indicators of health status. The "METAINFLAMMATION-CM Y2020/BIO-6600" project, a prospective controlled study, aimed to identify differential diagnostic tools and clinical features among three inflammatory conditions by comparing obesity status (low BMI vs.

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia.

Introduction: L-Asparaginase (L-Asp) is a key drug in the treatment of acute lymphoblastic leukemia (ALL); however, it is commonly associated with the occurrence of adverse events (AE). Risk factors such as age, sex, nutritional status, and some single nucleotide variants (SNVs) in specific genes could be related to hypersensitivity reactions to L-Asp. The objective of this study was to identify the influence of individual characteristics and three SNVs in the and genes on the occurrence of the most significant adverse events caused by the use of L-Asp in Mexican children with ALL.

Synthesis and characterization of a crosslinked deacetylated chitin modified chicken bone waste-derived hydroxyapatite and TiO biocomposite for defluoridation of drinking water.

This work represents an innovative approach to the synthesis and characterization of a chitosan-based biocomposite for fluoride adsorption. The work involved the development of a biocomposite based on modified chicken bone waste-derived hydroxyapatite and TiO. The composite was characterized using scanning electron microscopy with Energy Dispersive X-ray analysis (SEM-EDX), X-ray diffraction (XRD), Fourier-transform infrared analysis (FTIR), thermal-gravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS).

An Update of the Promise of Glycine Supplementation for Enhancing Physical Performance and Recovery.

Glycine, the simple amino acid, is a key component of muscle metabolism with proven cytoprotective effects and hypothetical benefits as a therapeutic nutrient. Cell, in vitro, and animal studies suggest that glycine enhances protection against muscle wasting by activating anabolic pathways and inhibiting proteolytic gene expression. Some evidence indicates that glycine supplementation may enhance peak power output, reduce lactic acid accumulation during high-intensity exercise, and improve sleep quality and recovery.

Acute Effect of Three Aerobic Exercise Intensities on Glomerular Filtration Rate in Healthy Older Adults.

Unlabelled: No consensus exists on whether acute aerobic exercise alters the glomerular filtration rate in older adults.

Objective: To assess the immediate effects of three aerobic exercise intensities on the estimated glomerular filtration rate (eGFR) in healthy, sedentary older adults.

Methods: Eighteen healthy, sedentary older adults (ten men and eight women) voluntarily participated in this study.

Somatotype, anthropometric characteristics, body composition, and global flexibility range in artistic gymnasts and sport hoop athletes.

The objective of the study was to analyze the somatotype, anthropometric characteristics, body composition, and the global flexibility battery test. A total of 48 athletes of both sexes from Women's Artistic Gymnastics, Men's Artistic Gymnastics, and Hoop Sport (mean ± standard deviation, age 12.50 ± 2.

Highlighting the adsorption mechanism of a fluoroquinolone antibiotic from wastewater on carbon xerogel by experiments, characterization, modelling and DFT simulation.

The application of a synthesized carbon xerogel (RFX) for the adsorptive removal from water of ciprofloxacin (CPX), a widely used fluoroquinolones-group antibiotic for humans and animals, has been reported in this work. The carbon xerogel was characterized by N adsorption-desorption isotherms, FTIR, Raman spectroscopy, TPD studies, elemental analysis, determination of isoelectric point (pH) and scanning electron microscopy (SEM). CPX adsorption experiments were conducted in batch mode, using results obtained with F400 commercial activated carbon for comparison purposes.

Streamlined chemical fixation method for morphological investigation of with scanning electron microscopy.

This method describes the preparation of specimen for scanning electron microscopy (SEM), starting from specimen collection to obtaining SEM images. Our approach involves preserving cellular structure and preventing cell degradation through chemical fixation and post-fixation without Osmium tetroxide (OsO), followed by air dried specimen placed onto Si substrate. Additionally, the method outlines the steps for mounting the prepared specimen onto SEM sample holder aluminum stubs, followed by coating with an ultrathin gold layer via thermal evaporation to enhance specimen/substrate/stub conductivity.

E-cigarette retail outlets in Mexico: a country that bans the sale.

Introduction: Restrictive e-cigarette policies have not allowed for the characterization of the sale of these tobacco products in the countries where they are implemented. This is because it is believed that there are no stores. However, the use of e-cigarettes persists in these countries.

An affordable operational oil spill monitoring system in action: A diachronic multiplatform analysis of recent incidents in the southern Gulf of Mexico.

The coexistence of marine sensitive areas with the oil industry requires robust preparedness and rapid response capabilities for monitoring and mitigating oil spill events. Scientifically proven satellite-based methods for the visual detection of oil spills are widely recognized as effective, low-cost, transferable, scalable, and operational solutions, particularly in developing economies. Following meticulous design and implementation, we adopted and executed a relatively low-cost operational monitoring and alert system for oil spill detection over the ocean surface and alert issuance.

Diverse applications of versatile quaternized chitosan salts: A review.

In the ever-evolving world of materials science, modifying natural polymers has garnered significant attention across diverse industries, driven by their inherent availability and cost-effectiveness. Among these, chitosan, a pseudo-natural cationic polymer, has emerged as a versatile player, finding applications in medical, pharmaceutical, filtration, and textile sectors, owing to its exceptional biodegradability, non-allergenicity, antimicrobial properties, and eco-friendly nature. However, the limitations of chitosan, such as low surface area, poor solubility at neutral to alkaline pH, and inadequate thermal-mechanical properties, have prompted researchers to explore innovative modification strategies, including graft copolymerization, quaternization, and cross-linking.