1,076 results match your criteria: "Autonomic Dysreflexia in Spinal Cord Injury"

Article Synopsis
  • - Individuals with spinal cord injury (SCI) above T6 often experience issues with blood pressure regulation, leading to persistent low blood pressure.
  • - A study tested the effects of daily midodrine (10 mg) versus placebo over 30 days on blood pressure, cerebral blood flow velocity (CBFv), and cognitive performance in hypotensive SCI patients.
  • - Results showed that midodrine significantly increased systolic blood pressure and diastolic CBFv compared to placebo, but did not significantly affect cognitive performance, indicating a need for further research on effective treatments.
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Making the Invisible Visible: Understanding Autonomic Dysfunctions Following Spinal Cord Injury.

Phys Med Rehabil Clin N Am

February 2025

International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada; ICORD-BSCC, UBC, 818 West 10th Avenue, Vancouver, British Columbia V5Z 1M9, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; G.F. Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, British Columbia, Canada. Electronic address:

Autonomic dysfunctions are a major challenge to individuals following spinal cord injury. Despite this, these consequences receive far less attention compared with motor recovery. This review will highlight the major autonomic dysfunctions following SCI predominantly based on our present understanding of the anatomy and physiology of autonomic control and available clinical data.

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Empowering Women's Health after Spinal Cord Injuries: A Timely and Practical Update.

Phys Med Rehabil Clin N Am

February 2025

Division of Physical Medicine and Rehabilitation, Department of Neurosurgery, UofL Health Frazier Rehab Institute, University of Louisville, 220 Abraham Flexner Way, Louisville, KY 40202, USA.

Women encompass about 20% of all the traumatic spinal cord injury (SCI) population and there is increased incidence and prevalence of women with SCIs. The most recent data estimate that approximately 40,000-45,000 women with SCI are living in the United States, increasing from previous years, with the most common cause still being motor vehicle collisions. Throughout their lifespan, women with SCI present with unique healthcare needs compare to the male population.

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Reduction of lower limb spasticity after the suppression of intravesical noxious stimulus documented by gait analysis.

J Spinal Cord Med

November 2024

Service de Médecine Physique et Réadaptation, Hôpital Henry-Gabrielle, Hospices Civils de Lyon, Saint-Genis-Laval, France.

Context: Spasticity is characterized by muscle hypertonia due to a velocity-dependent increase in tonic stretch reflexes, mostly related to hyperactive spinal reflexes. After spinal cord injury, the impact of noxious stimuli on autonomic dysreflexia is well documented. It is admitted in clinical practice that sublesional noxious stimuli can also increase spasticity.

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Background: Adults with spinal cord injury/dysfunction (SCI/D) face challenges with medications they take to manage their secondary conditions (e.g., pain, urinary tract infections, autonomic dysreflexia).

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Prevalence of autonomic dysreflexia during spinal cord stimulation after spinal cord injury.

J Neurophysiol

November 2024

Rehabilitation Medicine Research Center, Department of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, Minnesota, United States.

Article Synopsis
  • Clinical trials indicate that spinal cord stimulation can potentially restore motor functions in individuals with spinal cord injuries, but safety concerns due to unknown side effects continue to arise.
  • A study involving 11 participants found that 22% of trials demonstrated autonomic dysreflexia (AD), mostly asymptomatic, highlighting the need for careful monitoring during trials.
  • The research suggests that episodes of AD were more frequent with specific stimulation techniques and configurations, indicating that further investigation into these risks is essential as spinal cord stimulation technology advances.
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Neuroprotective agents ineffective in mitigating autonomic dysreflexia following experimental spinal cord injury.

Exp Neurol

December 2024

International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada; Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, Canada; GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, Canada. Electronic address:

Article Synopsis
  • The study investigates the cardiovascular dysfunction caused by spinal cord injury (SCI) and assesses the efficacy of four neuroprotective agents in aiding cardiovascular recovery.
  • Male Wistar rats were given spinal contusions and treated with Fluoxetine, Glyburide, Valproic acid, and Indomethacin, with outcomes measured through blood pressure changes, locomotor function, and lesion area.
  • The results showed that Indomethacin and Valproic acid led to high mortality rates, while Fluoxetine and Glyburide were tolerated, but none of the treatments significantly improved blood pressure control or locomotor function compared to the control group.
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Objective: Endoscopic spine surgery is an emerging technique of minimally invasive spine surgery. However, headache, seizure, and autonomic dysreflexia are possible irrigation-related complications following full-endoscopic lumbar discectomy (FELD). Pressure elevation through fluid irrigation may contribute to these adverse events.

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Study Design: Longitudinal observational study. Measurements were undertaken between weeks 4-6 post-spinal cord injury (SCI), repeated at week 8 and every 4 weeks thereafter until week 20 or rehabilitation discharge, whichever occurred first.

Objectives: Observe variation in measured resting energy expenditure (REE) and body composition in males undergoing SCI rehabilitation, compare REE with SCI-specific prediction equations incorporating fat-free mass (FFM), and explore the prevalence of clinical factors that may influence individual REE.

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Health consequences associated with poor diet and nutrition in persons with spinal cord injuries and disorders.

Disabil Rehabil

September 2024

Department of Veterans Affairs, Center of Innovation for Complex Chronic Healthcare (CINCCH), Edward Hines Jr. VA Hospital, Hines, IL, USA.

Article Synopsis
  • The study explores the health impacts of poor diet on individuals with spinal cord injuries and disorders (SCI/D) by conducting in-depth interviews with healthcare providers.
  • Key findings highlight seven major health consequences linked to inadequate nutrition, including weight gain, cardiometabolic issues, bowel dysfunction, and poor mental health.
  • The authors recommend increasing awareness among SCI/D patients regarding these risks and the need for tailored nutrition interventions to address these health issues.
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Autonomic dysreflexia in patients with cancer and spinal cord injury: a case series.

Spinal Cord Ser Cases

September 2024

Rehabilitation Medicine Service, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Introduction: Autonomic dysreflexia (AD) is a potentially life-threatening syndrome that can occur in patients with traumatic injury to the spinal cord; however, it has not been well described in patients with non-traumatic spinal cord injury (SCI) from cancer and its treatments.

Case Presentation: We report four cases of autonomic dysreflexia secondary to primary spinal cord tumors and metastatic disease to the spine, and as sequela to cancer treatment. The clinical characteristics, diagnostic considerations, and therapeutic strategies used to mitigate the symptoms are discussed.

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Article Synopsis
  • The study aimed to evaluate how secondary health conditions impact the quality of life and wellbeing of Canadians with spinal cord injury using four different measurement tools.
  • The analysis included data from 364 adults living with spinal cord injuries, highlighting a trend where higher problem ratings from secondary health conditions related to lower quality of life scores.
  • Significant differences were found in the outcomes across the various instruments used, with certain conditions like respiratory issues and depression being linked to the lowest wellbeing ratings.
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Postganglionic cholinergic collaterals drive pathological sympathetic hyperactivity.

J Physiol

August 2024

Departments of Physiology and Pharmacology, Cardiac Sciences, Clinical Neurosciences, Biomedical Engineering, Libin Cardiovascular Institute, Hotchkiss Brain Institute, RESTORE.network, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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Study Design: Systematic review and meta-analysis.

Objectives: Many individuals with spinal cord injury (SCI) experience autonomic dysfunction, including profound impairments to bowel and cardiovascular function. Neurogenic bowel dysfunction (NBD) is emerging as a potential determinant of quality of life (QoL) after SCI.

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Background: People with spinal cord injury (SCI) are at high risk of developing pressure injuries. Reports in the SCI-community had indicated that a new class of wound treatment, MPPT (micropore-particle-technology), was effective in treating pressure injuries. The British Spinal Injuries Association therefore conducted a survey among MPPT-users to learn from their experiences.

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Article Synopsis
  • * Using data from a previous study, researchers recorded heart rhythms for 24 hours to analyze various HRV metrics, revealing similar daily patterns in both groups, with lower values in the late afternoon and peaks during the night.
  • * Overall, while participants with higher lesions showed generally lower HRV metrics compared to those with lower lesions, some specific measurements like RMSSD, HF, and LF peaked differently, indicating unique cardiovascular responses based on the injury level.
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Robust structural remodeling and synaptic plasticity occurs within spinal autonomic circuitry after severe high-level spinal cord injury (SCI). As a result, normally innocuous visceral or somatic stimuli elicit uncontrolled activation of spinal sympathetic reflexes that contribute to systemic disease and organ-specific pathology. How hyperexcitable sympathetic circuitry forms is unknown, but local cues from neighboring glia likely help mold these maladaptive neuronal networks.

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Risk factors of video urodynamics and bladder management for long-term complications in patients with chronic spinal cord injury.

Sci Rep

June 2024

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, No.707 Sec.3, Zhongyang Rd., Hualien City, 970473, Taiwan (R.O.C.).

This study explores 15-year urological complications in chronic spinal cord injury (SCI) patients and investigates the predictive factors from video-urodynamic study (VUDS) and bladder management. Analyzing 864 SCI patients with a mean 15.6-year follow-up, we assessed complications and utilized multivariate logistic regression for risk evaluation.

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Article Synopsis
  • * Healthcare professionals (HCPs) often lack the necessary confidence and specific knowledge about SCI to effectively support these mothers.
  • * An international panel developed a resource based on research and surveys to provide evidence-based recommendations for various HCPs to better support breastfeeding for mothers with SCI.
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Introduction: Individuals with spinal cord injury (SCI) commonly have autonomic dysreflexia (AD) with increased sympathetic activity. After SCI, individuals have decreased baroreflex sensitivity and increased vascular responsiveness.

Objective: To evalate relationship between baroreflex and blood vessel sensitivity with autonomic dysreflexia symptoms.

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Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement, reducing symptoms of autonomic dysreflexia, improving functions mediated by muscles of the pelvic floor (e.g.

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Methods: We used a Urethrotech catheterisation device in 57 male patients with spinal cord injury, in whom urethral catheterisation was unsuccessful or previous catheterisation was difficult.

Results: Urethrotech catheter could be inserted in 51 patients. No patient developed urinary tract infection.

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Study Design: Systematic review and meta-analysis.

Objectives: The current study aimed to assess the efficacy and safety of Onabotulinum toxin A (OBTX-A) treatment for neurogenic detrusor overactivity (NDO) in spinal cord injury (SCI) patients.

Setting: Iran.

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