185 results match your criteria: "Autonoma University of Barcelona[Affiliation]"

Robotic kidney transplantation.

Nat Rev Urol

September 2024

Department of Urology, Fundació Puigvert, Autonomous University of Barcelona, Barcelona, Spain.

Kidney transplantation is the best treatment option for patients with end-stage renal disease owing to improved survival and quality of life compared with dialysis. The surgical approach to kidney transplantation has been somewhat stagnant in the past 50 years, with the open approach being the only available option. In this scenario, evidence of reduced surgery-related morbidity after the introduction of robotics into several surgical fields has induced surgeons to consider robot-assisted kidney transplantation (RAKT) as an alternative approach to these fragile and immunocompromised patients.

View Article and Find Full Text PDF

Targeted therapy or immunotherapy in BRAF-mutated metastatic melanoma: a Spanish center's decade of experience.

Front Oncol

February 2024

Medical Oncology Department, Institut Catala d´Oncologia Badalona, Universitari Hospital Germans Trias i Pujol, Badalona-Applied Research Group in Oncology (B-ARGO), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.

Background: Targeted therapies and immunotherapy are currently considered the mainstay first-line treatment for advanced BRAF-mutated melanoma. However, the impact of treatment (targeted therapy and immunotherapy) and the prognostic factors are still not clear.

Material And Methods: Medical records of 140 patients diagnosed with advanced melanoma between 2011 and 2021 were retrospectively reviewed to extract demographic, BRAF status, treatment, performance status, and survival data.

View Article and Find Full Text PDF

Proposal of a standardized training curriculum for open and robot-assisted kidney transplantation.

Minerva Urol Nephrol

February 2024

Unit of Urological Robotic Surgery and Renal Transplantation, Careggi Hospital, University of Florence, Florence, Italy -

Standardized training programs for open (OKT) and robot-assisted kidney transplantation (RAKT) remain unmet clinical needs. To fill this gap, we designed a modified Delphi Consensus aiming to propose the first structured surgical curricula for both OKT and RAKT, involving a multispecialty international panel of experts. Two web-based surveys were built drafting two separate series of statements (for OKT and RAKT, respectively).

View Article and Find Full Text PDF

Context: Thulium fiber laser (TFL) emerged as a competitor of holmium:yttrium aluminum garnet (Ho:YAG) laser for the treatment of urinary stones.

Objective: To compare the efficacy between Ho:YAG and TFL for laser lithotripsy of renal and ureteral stones.

Evidence Acquisition: A literature search was conducted using PubMed/Medline, Embase, and Web of Science databases to identify reports published until May 2023.

View Article and Find Full Text PDF

Purpose: To access the current scenario of robotic-assisted radical prostatectomy training in multiple centers worldwide.

Methods: We created a multiple-choice questionnaire assessing all details of robotic-assisted radical prostatectomy training with 41 questions divided into three different categories (responder demography, surgical steps, and responder experience). The questionnaire was created and disseminated using the "Google Docs" platform.

View Article and Find Full Text PDF

The laparoscopic approach represents the standard of treatment for renal and adrenal diseases, and its use is increasing even outside referral centres. Although most procedures are routinely performed, intraoperative complications do not occur, and the rate and predictive factors of these complications have not been established. The aim of this study was to evaluate the incidence and type of intraoperative complications and to identify predictive factors in patients undergoing laparoscopic renal and adrenal surgery.

View Article and Find Full Text PDF

Objectives: To identify the predictive factors of prostate cancer extracapsular extension (ECE) in an institutional cohort of patients who underwent multiparametric MRI of the prostate prior to radical prostatectomy (RP).

Patients And Methods: Overall, 126 patients met the selection criteria, and their medical records were retrospectively collected and analysed; 2 experienced radiologists reviewed the imaging studies. Logistic regression analysis was conducted to identify the variables associated to ECE at whole-mount histology of RP specimens; according to the statistically significant variables associated, a predictive model was developed and calibrated with the Hosmer-Lomeshow test.

View Article and Find Full Text PDF

Purpose: This study aims to assess the effectiveness and safety of combining the Preserflo™ MicroShunt implant (MicroShunt) with a simultaneous Ologen™ implant in patients with glaucoma.

Methods: We conducted a retrospective study on consecutive patients with medically uncontrolled glaucoma who underwent MicroShunt + Ologen implantation as a standalone procedure or in combination with phacoemulsification (combined procedure). Success was defined as achieving an intraocular pressure (IOP) of 6-15 mmHg at 18 months post surgery, with a preoperative IOP reduction of at least 20%, and without (complete success) or with (qualified success) the need for antiglaucoma medications.

View Article and Find Full Text PDF

Purpose: Salvage robotic-assisted radical prostatectomy (S-RARP) has gained prominence in recent years for treating patients with cancer recurrence following non-surgical treatments of Prostate Cancer. We conducted a systematic literature review to evaluate the role and outcomes of S-RARP over the past decade.

Material And Methods: A systematic review was conducted, encompassing articles published between January 1st, 2013, and June 1st, 2023, on S-RARP outcomes.

View Article and Find Full Text PDF
Article Synopsis
  • - A new predictive model was developed to assess long-term kidney function impairment after partial nephrectomy (PN), using data from patients who underwent minimally invasive surgery between 2005 and 2022.
  • - A machine-learning approach, specifically the classification and regression tree (CART) method, identified key predictors of chronic kidney disease (CKD) stage changes in 381 patients over an average follow-up of 69 months, with 27% experiencing CKD progression.
  • - The model classified patients into four clusters based on their CKD progression risk, demonstrating that initial CKD stage and overall health status (ACCI) are crucial in determining long-term outcomes, potentially guiding more attentive patient monitoring post-surgery.
View Article and Find Full Text PDF

Background: Preclinical studies have shown that the sympathetic nervous system is involved in the development of metastases, suggesting a potential antitumor effect of beta-blockers. These findings sparked a controversy over the past decade regarding the direction of the association between beta-blocker use and prostate cancer (PCa) mortality. To investigate this association, we conducted a systematic review and meta-analysis.

View Article and Find Full Text PDF

Context: It is unclear whether a magnetic resonance imaging (MRI)-targeted transperineal (TP) biopsy can improve the detection of clinically significant prostate cancer (csPCa).

Objective: To compare the MRI-targeted TP and transrectal (TR) approaches for csPCa detection.

Evidence Acquisition: A literature search was conducted using the PubMed/Medline, Embase, and Web of Science databases to identify reports published until February 2023.

View Article and Find Full Text PDF

Purpose: To learn about the history and development of en bloc resection of bladder tumour (ERBT), and to discuss its future directions in managing bladder cancer.

Methods: In this narrative review, we summarised the history and early development of ERBT, previous attempts in overcoming the tumour size limitation, consolidative effort in standardising the ERBT procedure, emerging evidence in ERBT, evolving concepts in treating large bladder tumours, and the future directions of ERBT.

Results: Since the first report on ERBT in 1980, there has been tremendous advancement in terms of its technique, energy modalities and tumour retrieval methods.

View Article and Find Full Text PDF
Article Synopsis
  • This research aims to enhance the understanding of clear-cell renal cell carcinoma (ccRCC) with venous tumor thrombus (VTT) to better select candidates for additional therapy based on their recurrence risk.
  • The study retrospectively analyzed data from 604 patients with nonmetastatic ccRCC, finding that discrepancies in tumor grade between the primary tumor and VTT significantly influenced disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS).
  • Incorporating tumor grade discrepancy into predictive models improved their accuracy, indicating that this information can lead to more personalized and effective treatment strategies for patients.
View Article and Find Full Text PDF

Introduction: To determine associations between prostate cancer (PCa) tumor burden measured on biopsy or multiparametric magnetic resonance imaging (mpMRI) and outcomes in intermediate-risk (IR) International Society of Urological Pathology (ISUP) grade 2 men managed with primary radical prostatectomy (RP).

Methods: This retrospective, multicenter study was conducted in eight referral centers. The cohort included IR PCa patients who had ISUP 2 at biopsy.

View Article and Find Full Text PDF
Article Synopsis
  • The study reviews existing research on outpatient endoscopic enucleation of the prostate to assess its feasibility and outcomes for treating benign prostatic obstruction.
  • A thorough literature search identified ten studies for the systematic review, with a total of 1942 patients, and a meta-analysis involving 1228 patients, showing a high success rate for same-day discharge (84%) and a low unplanned readmission rate (3%).
  • The findings suggest that same-day discharge after this procedure is both feasible and safe for well-selected patients, with lower rates of postoperative readmission and complications compared to standard care protocols.
View Article and Find Full Text PDF

Single-port robotic partial nephrectomy: impact on perioperative outcomes and hospital stay.

Ther Adv Urol

June 2023

Renal Cancer Working Group, Young Academic Urologists (YAU), European Association of Urology (EAU), Arnhem, The Netherlands.

Article Synopsis
  • * Research indicates that outcomes of SP-robotic PN are comparable to traditional multi-arm robotic surgery, with some studies showing less postoperative pain and overall lower complexity in treated renal masses.
  • * Further prospective studies are needed to evaluate long-term effectiveness and safety, as current data suggests SP-robotic PN is feasible and safe, though cost-effectiveness remains unstudied.
View Article and Find Full Text PDF

Many patients with upper tract urothelial carcinoma (UTUC) outside of the low-risk criteria may possess low absolute risks of distant progression. Herein, we hypothesized that careful selection of high-risk patients undergoing an endoscopic approach could result in acceptable oncologic outcomes. Patients with high-risk UTUC managed endoscopically between 2015 and 2021 were retrospectively identified from a prospectively maintained single academic institution database.

View Article and Find Full Text PDF

Purpose Of Review: Kidney transplantation in low-weight recipients (<15 kg) is a challenging surgery with special characteristics. We proposed to perform a systematic review to determine the postoperative complication rate and the type of complications after kidney transplantation in low-weight recipients (<15 kg). The secondary objectives were to determine graft survival, functional outcomes, and patient survival after kidney transplantation in low-weight recipients.

View Article and Find Full Text PDF

Reduced- vs full-dose BCG in bladder cancer: A systematic review and meta-analysis.

Actas Urol Esp (Engl Ed)

April 2023

Department of Urology, Fundació Puigvert, Autonoma University of Barcelona, Barcelona, Spain. Electronic address:

Objective: To assess the oncologic outcomes and the safety profile of a reduced-dose versus full-dose BCG regimen in patients with non-muscle-invasive bladder cancer (NMIBC).

Material And Methods: We performed a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The PubMed, Embase, and Web of Science databases were searched in January 2022 for studies that analyzed oncological outcomes and compared between reduced- and full-dose BCG regimens.

View Article and Find Full Text PDF