1,048 results match your criteria: "Autism Research Centre[Affiliation]"

Understanding social behaviours across neurodiverse young people: roles of social cognition and self-regulation.

BJPsych Open

January 2025

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Canada; Department of Psychology, Faculty of Arts & Science, University of Toronto, Canada; Department of Psychiatry, The Hospital for Sick Children, Toronto, Canada; Autism Research Centre, Department of Psychiatry, University of Cambridge, UK; Department of Psychiatry, National Taiwan University Hospital, Taiwan; and Department of Psychiatry, National Taiwan University College of Medicine, Taiwan.

Background: Differences in social behaviours are common in young people with neurodevelopmental conditions (NDCs). Recent research challenges the long-standing hypothesis that difficulties in social cognition explain social behaviour differences.

Aims: We examined how difficulties regulating one's behaviour, emotions and thoughts to adapt to environmental demands (i.

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Probing Autism and ADHD subtypes using cortical signatures of the T1w/T2w-ratio and morphometry.

Neuroimage Clin

January 2025

The Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental conditions that share genetic etiology and frequently co-occur. Given this comorbidity and well-established clinical heterogeneity, identifying individuals with similar brain signatures may be valuable for predicting clinical outcomes and tailoring treatment strategies. Cortical myelination is a prominent developmental process, and its disruption is a candidate mechanism for both disorders.

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Autistic and transgender/gender diverse people's experiences of health and healthcare.

Mol Autism

January 2025

Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18B Trumpington Road, Cambridge, CB2 8AH, UK.

Background: Autistic people and transgender/gender diverse people experience poorer healthcare experiences and greater risk of diagnosed, suspected, and assessment recommended health conditions, compared to non-autistic and cisgender individuals, respectively. Despite this, there is a paucity of studies on the healthcare experiences and health outcomes of transgender/gender diverse autistic individuals.

Methods: We compared the healthcare experiences and health outcomes of cisgender autistic (n = 1094), transgender/gender diverse autistic (n = 174), and cisgender non-autistic adults (n = 1295) via an anonymous, self-report survey.

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Background: The rollout of the National Disability Insurance Scheme (NDIS) has transformed the Australian funding landscape for individuals with disability and their families. This study examined whether the profiles of autistic children and their families accessing an early intervention (EI) setting have changed following its introduction.

Methods: The cognition and behavioural profiles of children funded under the NDIS ( = 58) were compared to children who had received block government funding (= 58).

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Atypical face processing is commonly reported in autism. Its neural correlates have been explored extensively across single neuroimaging modalities within key regions of the face processing network, such as the fusiform gyrus (FFG). Nonetheless, it is poorly understood how variation in brain anatomy and function jointly impacts face processing and social functioning.

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Gender Inequalities in Employment of Parents Caring for Children With Autism Spectrum Disorder in China: Cross-Sectional Study.

JMIR Pediatr Parent

December 2024

School of Population Medicine and Public Health, Chinese Academy of Medical Sciences, Peking Union Medical College, Number 31, Road 3rd, Bei-Ji-Ge, Dongcheng District, Beijing, 100730, China, 86 13621224975.

Background: The increasing need for child care is placing a burden on parents, including those with children with autism.

Objective: The aim of this study was to examine the employment status of Chinese mothers and fathers with children with autism spectrum disorder (ASD), as well as to investigate the factors that affected their employment decisions.

Methods: An online national survey was completed by the parents of 5018 children and adolescents with ASD aged 2-17 years (4837 couples, 181 single mothers, and 148 single fathers).

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The placenta is a fetal endocrine organ that secretes many neuroactive factors, including steroids, that play critical roles in brain development. The study of the placenta-brain axis and the links between placental function and brain development represents an emerging research area dubbed "neuroplacentology." The placenta drives many circulating fetal steroids to very high levels during gestation.

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Purpose: Social support is a known facilitator of exercise for people with disability. A qualitative approach was used to understand current social support practices in community gyms for young adults with disability.

Methods: Embedded within a larger project "Getting Young adult Moving - Supporting Participation and Access to Recreation Centres" (GYM-SPARC), semi-structured interviews were completed with 25 gym staff, representing 29 community gym facilities across Victoria, Australia.

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Initial Validation of the Mandarin Translation of the Stanford Social Dimensions Scale (SSDS).

J Autism Dev Disord

December 2024

Aspect Research Centre for Autism Practice, Autism Spectrum Australia, Level 5, Tower B, The Zenith, 821 Pacific Highway, Chatswood, NSW, 2067, Australia.

This study aimed to validate the Mandarin translation of the Stanford Social Dimensions Scale (SSDS). The initial validation sample consisted of 480 children with Autism Spectrum Disorder (ASD) (M = 9.35).

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Chromosome X-wide common variant association study in autism spectrum disorder.

Am J Hum Genet

January 2025

The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; McLaughlin Centre and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

Autism spectrum disorder (ASD) displays a notable male bias in prevalence. Research into rare (<0.1) genetic variants on the X chromosome has implicated over 20 genes in ASD pathogenesis, such as MECP2, DDX3X, and DMD.

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Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome.

J Neurodev Disord

December 2024

Carolina Institute for Developmental Disabilities (CIDD), University of North Carolina at Chapel Hill, 101, Renee Lynne Court, Carrboro, NC, 27510, USA.

Background: Down syndrome (DS) is the most common congenital neurodevelopmental disorder, present in about 1 in every 700 live births. Despite its prevalence, literature exploring the neurobiology underlying DS and how this neurobiology is related to behavior is limited. This study fills this gap by examining cortical volumes and behavioral correlates in school-age children with DS.

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Self-injurious behaviors (SIB) commonly occur in autism spectrum disorder (ASD) and span diverse topographies of self-inflicted behaviors ranging from head banging to hitting oneself against hard objects. Despite the high rates of SIB in autistic individuals, relatively little research has focused on psychological factors associated with the development and maintenance of SIB in individuals with autism and moderate-profound intellectual disability (ID). This commentary synthesizes existing literature on SIB and highlights the need for more research focused on psychological correlates and mechanisms in autistic individuals with moderate-profound ID.

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Aim: To synthesize the experiences of 15- to 34-year-olds with cerebral palsy (CP) as they participate in key life situations of young adulthood.

Method: A mixed-methods scoping review was undertaken and six electronic databases searched (January 2001 to August 2023). Participation foci and thematic outcomes were mapped to the International Classification of Functioning, Disability and Health.

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Conflicting Definitions of Self-Regulation in Occupational Therapy: A Scoping Review.

Phys Occup Ther Pediatr

December 2024

School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.

Article Synopsis
  • The study aims to analyze how self-regulation is understood and utilized within occupational therapy literature, spanning from 2000 to mid-2023.
  • Using systematic review methods, 4,159 articles were screened, resulting in the inclusion of 64 studies that provided insights into the concept of self-regulation.
  • Content analysis identified five key constructs related to self-regulation, highlighting inconsistencies in how these concepts are defined and measured in occupational therapy practices.
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Article Synopsis
  • Very large sample sizes are essential for studying autism, and data sharing among diverse studies can help create a unified dataset through data harmonization, which aligns scores from different assessment tools.
  • The study used data from over 700 participants, comparing scores on two adaptive functioning measures (VABS and ABAS) and employed multiple regression techniques to predict VABS scores using ABAS scores and other demographic factors.
  • Results revealed significantly higher VABS scores in the autism group compared to the ABAS scores, with age being a key factor, and all regression techniques performed similarly in predicting outcomes, highlighting the importance of ABAS score, diagnosis, and age in the prediction model.
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Introduction: Patient engagement in research aims to foster meaningful partnerships, integrating patient experiences into the research process. This paper describes the development of a Terms of Reference (ToR) to support these meaningful partnerships. While engagement improves data collection and empowerment, ineffective engagement can lead to negative outcomes.

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Developmental and Functional Outcomes Amongst Culturally and Linguistically Diverse Autistic Children.

J Autism Dev Disord

November 2024

Olga Tennison Autism Research Centre, School of Psychology and Public Health, La Trobe University, Melbourne, Australia.

Children typically learn by attending to other people. Autism traits may impact access to social stimuli fundamental to early learning, increasing children's likelihood of a learning disability. Recent reports have highlighted that Autistic children from minority backgrounds have a higher likelihood of co-occurring intellectual disability.

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Self-injurious behaviors (SIB) encompass a heterogeneous set of self-inflicted aggressive behaviors that are highly prevalent in autistic youth. Existing research on SIB in autism spectrum disorder (ASD) has been limited by significant methodological and conceptual inconsistencies. Thus, the current study leveraged item-level data capturing the severity of unique SIB topographies to further understanding of factors associated with distinct SIB in a sample of 582 autistic youth (M = 12.

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How auditory processing influences the autistic profile: A review.

Autism Res

December 2024

Department of Linguistics, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.

We need to combine sensory data from various sources to make sense of the world around us. This sensory data helps us understand our surroundings, influencing our experiences and interactions within our everyday environments. Recent interest in sensory-focused approaches to supporting autistic people has fixed on auditory processing-the sense of hearing and the act of listening-and its crucial role in language, communications, and social domains, as well as non-social autism-specific attributes, to understand better how sensory processing might differ in autistic people.

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Background: Past research has found that overall anxiety and social anxiety symptoms are associated with the occurrence of social and communication challenges within autistic populations.

Objective: The aim of this study was to determine whether generalized anxiety disorder symptoms were associated with social and communication symptoms in autistic youth.

Method: The cross-sectional sample was comprised of 253 autistic youth aged 8-18 (196 Males, 57 Females).

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The influence of body posture on facial expression perception in Autism.

Sci Rep

November 2024

Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Maindy Road, CF24 4HQ, Cardiff, UK.

Article Synopsis
  • Facial expression perception is affected by body posture, with individuals more biased toward the emotional cue from the body.
  • Lower precision in facial expression recognition leads to a greater influence of body posture, especially in individuals with autism, who often have reduced discrimination abilities.
  • Both autistic and non-autistic adults show a strong body context influence on facial perception, but it is more pronounced in autistic individuals, highlighting a link between body posture effects and facial expression recognition precision in both groups.
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