55 results match your criteria: "Austrian Research Centers GmbH -ARC[Affiliation]"
A comparative analysis of polyurethane hydrogel for immobilization of IgG on chips.
Anal Chim Acta
June 2007
Austrian Research Centers GmbH-ARC, Department of Bioresources, 2444 Seibersdorf, Austria.
Hydrogels are considered an optimum material for protein chip surfaces, since they provide a quasi-liquid environment which allows protein activity to be maintained and shows good spot morphology as well as excellent immobilization capacity. In the following, we present a polyurethane (PU) chip that electrostatically binds IgG. The PU surface is optimized with regard to layer thickness (approximately 200 nm), hydrogel (2%) and immobilized antibody concentration (0.
View Article and Find Full Text PDFPharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil.
Epilepsia
September 2007
Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Vienna, AustriaDepartment of Radiopharmaceuticals, Austrian Research Centers GmbH - ARC, Seibersdorf, AustriaDivision of Neuroscience, Faculty of Medicine, Imperial College, and MRC Clinical Sciences Centre, Hammersmith Hospital, London, UKDepartment of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, United KingdomDepartment of Medical Computer Sciences, Medical University of Vienna, Vienna, AustriaDepartment of Neurology, Medical University of Vienna, Vienna, AustriaDepartment of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The NetherlandsInstitute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, AustriaDepartment of Radiology, Division of Neuroradiology, Medical University of Vienna, Vienna, AustriaDepartment of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Purpose And Methods: Regional overexpression of the multidrug transporter P-glycoprotein (P-gp) in epileptic brain tissue may lower target site concentrations of antiepileptic drugs and thus contribute to pharmacoresistance in epilepsy. We used the P-gp substrate R-[(11)C]verapamil and positron emission tomography (PET) to test for differences in P-gp activity between epileptogenic and nonepileptogenic brain regions of patients with drug-resistant unilateral temporal lobe epilepsy (n = 7). We compared R-[(11)C]verapamil kinetics in homologous brain volumes of interest (VOIs) located ipsilateral and contralateral to the seizure focus.
View Article and Find Full Text PDFHigh-resolution numerical model of the middle and inner ear for a detailed analysis of radio frequency absorption.
Phys Med Biol
April 2007
Austrian Research Centers GmbH-ARC, ITM, A-2444 Seibersdorf, Austria.
In order to enable a detailed analysis of radio frequency (RF) absorption in the human middle and inner ear organs, a numerical model of these organs was developed at a spatial resolution of 0.1 mm, based on a real human tissue sample. The dielectric properties of the liquids (perilymph and endolymph) inside the bony labyrinth were measured on samples of ten freshly deceased humans.
View Article and Find Full Text PDFPredicting initiation and termination of atrial fibrillation from the ECG.
Biomed Tech (Berl)
February 2007
Austrian Research Centers GmbH - ARC - eHealth Systems, Graz, Austria.
Article Synopsis
- Atrial fibrillation (AF) is a common heart arrhythmia affecting over two million people in the US, and there's a need for better ways to choose effective treatments for patients.
- A new software system has been developed to predict when AF will start or stop by analyzing ECG data, with successful predictions being made about 75% of the time for AF initiation.
- The prediction methods involve detecting unusual heartbeats and examining the shape of P waves, while terminating AF relies on measuring a significant frequency that tends to decrease before an episode ends.
Reliable allele detection using SNP-based PCR primers containing Locked Nucleic Acid: application in genetic mapping.
Plant Methods
February 2007
Bioresources Department, Austrian Research Centers GmbH-ARC, A-2444, Seibersdorf, Austria.
Background: The diploid, Solanum caripense, a wild relative of potato and tomato, possesses valuable resistance to potato late blight and we are interested in the genetic base of this resistance. Due to extremely low levels of genetic variation within the S. caripense genome it proved impossible to generate a dense genetic map and to assign individual Solanum chromosomes through the use of conventional chromosome-specific SSR, RFLP, AFLP, as well as gene- or locus-specific markers.
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