2 results match your criteria: "Austria [2] Center for Molecular Medicine (CeMM)[Affiliation]"
Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies.
J Lipid Res
February 2015
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Krems, Austria.
Article Synopsis
- Oxidation-specific epitopes (OSEs) on apoptotic cells and oxidized LDL are recognized by the immune system and play a role in inflammation, particularly in cardiovascular diseases.
- The study found that circulating microparticles (MPs) from both healthy individuals and patients with heart attacks carry OSEs, mainly the malondialdehyde (MDA) type, and these MPs can stimulate immune responses.
- Researchers discovered that MDA(+) MPs are more prevalent at the sites of heart damage in patients, suggesting that IgM antibodies targeting these OSEs may help protect against cardiovascular diseases.
Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine.
J Lipid Res
October 2014
Department of Medicine, University of California, San Diego, La Jolla, CA Department of Biomedical Sciences, University of Copenhagen, Denmark.
Immunization with homologous malondialdehyde (MDA)-modified LDL (MDA-LDL) leads to atheroprotection in experimental models supporting the concept that a vaccine to oxidation-specific epitopes (OSEs) of oxidized LDL could limit atherogenesis. However, modification of human LDL with OSE to use as an immunogen would be impractical for generalized use. Furthermore, when MDA is used to modify LDL, a wide variety of related MDA adducts are formed, both simple and more complex.
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