Prognostic value of manual versus automatic methods for assessing extents of resection and residual tumor volume in glioblastoma.

Objective: The extent of resection (EOR) and postoperative residual tumor (RT) volume are prognostic factors in glioblastoma. Calculations of EOR and RT rely on accurate tumor segmentations. Raidionics is an open-access software that enables automatic segmentation of preoperative and early postoperative glioblastoma using pretrained deep learning models.

Exploring the Unique Properties and Superior Schwann Cell Guiding Abilities of Spider Egg Sac Silk.

Spider silk (SPSI) is a promising candidate for use as a filler material in nerve guidance conduits (NGCs), facilitating peripheral nerve regeneration by providing a scaffold for Schwann cells (SCs) and axonal growth. However, the specific properties of SPSI that contribute to its regenerative success remain unclear. In this study, the egg sac silk of is investigated, which contains two distinct fiber types: tubuliform (TU) and major ampullate (MA) silk.

Prohibiting Babel-A call for professional remote interpreting services in pre-operation anaesthesia information.

Introduction: Language barriers within clinical settings pose a threat to patient safety. As a potential impediment to understanding, they hinder the process of obtaining informed consent and uptake of critical medical information. This study investigates the impact of the current use of interpreters, with a particular focus on of engaging laypersons as interpreters, rather than professional interpreters potentially affecting patient safety.

Characteristics of ChatGPT users from Germany: Implications for the digital divide from web tracking data.

A major challenge of our time is reducing disparities in access to and effective use of digital technologies, with recent discussions highlighting the role of AI in exacerbating the digital divide. We examine user characteristics that predict usage of the AI-powered conversational agent ChatGPT. We combine behavioral and survey data in a web tracked sample of N = 1376 German citizens to investigate differences in ChatGPT activity (usage, visits, and adoption) during the first 11 months from the launch of the service (November 30, 2022).

Incidence and predictors of weaning failure from veno-arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock.

Aims: This study aimed to investigate incidence and predictors of weaning failure and in-hospital death after successful weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS).

Methods And Results: Overall, 685 patients with CS treated with VA-ECMO from 23 tertiary care centres in 7 countries were analysed (median age 57 [interquartile range 49-66] years, 542 [79.1%] male, median lactate 7.

Subintuitionistic logics and their modal companions: a nested approach.

In the present paper we deal with subintuitionistic logics and their modal companions. In particular, we introduce nested calculi for subintuitionistic systems and for modal logics in the modal cube ranging from to . The latter calculi differ from standard nested systems, as there are multiple rules handling the modal operator.

Mesenchymal stem cell therapies evidence in the treatment of irradiated salivary glands: A scoping review.

Background: Radiotherapy is one of the main treatments for head and neck cancer; however, due to its non-selectivity the glandular tissue can be affected. This scoping review aimed to identify the evidence about mesenchymal stem cell therapies for irradiated salivary gland regeneration.

Material And Methods: Two independent reviewers performed a literature search in MEDLINE/PubMed, Scopus, and Web of Science.

LPMO-Catalyzed Oxidation of Cellulosic Fibers with Controlled Addition of a Reductant and HO.

Cellulose-derived biomaterials offer a sustainable and versatile platform for various applications. Enzymatic engineering of these fibers, particularly using lytic polysaccharide monooxygenases (LPMOs), shows promise due to the ability to introduce functional groups onto cellulose surfaces, potentially enabling further functionalization. However, harnessing LPMOs for fiber engineering remains challenging, partly because controlling the enzymatic reaction is difficult and partly because limited information is available about how LPMOs modify the fibers.

Revision of the millipede family Dalodesmidae in Madagascar, with descriptions of two new Malagasy species of Cook, 1896 (Diplopoda, Polydesmida).

The family Dalodesmidae Cook, 1896 in the fauna of Madagascar is reviewed and shown to presently encompass eight species in three genera: Cook, 1896 (six species), Brölemann, 1916 (one species), and de Saussure & Zehntner, 1897 (one species). These genera are diagnosed, and their respective species keyed, all being endemic to Madagascar proper and/or the immediately adjacent islets of Nosy Be and/or Nosy Sakatia. currently contains six species, including two new, all supplied either with brief descriptive notes and available iconography or extensive descriptions and new illustrations, as follows: (Brandt, 1841), from an unspecified locality in Madagascar, now redescribed from a male specimen from Makira, northeastern Madagascar; (Attems, 1898), from Nosy Be Isle; Hoffman, 1974, from Ambohimitombo, central Madagascar; Cook, 1896 (= (de Saussure & Zehntner, 1897), ), originally described from an unspecified locality in central Madagascar, with a male type and additional males identified as recorded from the Andasibe National Park (= Périnet) in east-central Madagascar.

Effects of infection on neonates: a meta-analysis.

Objective: (UU) is an opportunistic pathogen transmitted from mother to fetus, potentially causing neonatal diseases. Despite extensive research, its association with these diseases remains uncertain. This study analyzes the effects of UU infection on newborns.

Enhanced energy storage in relaxor (1-x)BiNaTiO-xBaZrTiO thin films by morphotropic phase boundary engineering.

Perovskites at the crossover between ferroelectric and relaxor are often used to realize dielectric capacitors with high energy and power density and simultaneously good efficiency. Lead-free BiNaTiO is gaining importance in showing an alternative to lead-based devices. Here we show that ()BiNaTiO - BaZr Ti O (best: 0.

Multiple, Single Trait GWAS and Supervised Machine Learning Reveal the Genetic Architecture of Fraxinus excelsior Tolerance to Ash Dieback in Europe.

Common ash (Fraxinus excelsior) is under intensive attack from the invasive alien pathogenic fungus Hymenoscyphus fraxineus, causing ash dieback at epidemic levels throughout Europe. Previous studies have found significant genetic variation among genotypes in ash dieback susceptibility and that host phenology, such as autumn yellowing, is correlated with susceptibility of ash trees to H. fraxineus; however, the genomic basis of ash dieback tolerance in F.

Enhancing quality and yield of recombinant secretory IgA antibodies in Nicotiana benthamiana by endoplasmic reticulum engineering.

The production of complex multimeric secretory immunoglobulins (SIgA) in Nicotiana benthamiana leaves is challenging, with significant reductions in complete protein assembly and consequently yield, being the most important difficulties. Expanding the physical dimensions of the ER to mimic professional antibody-secreting cells can help to increase yields and promote protein folding and assembly. Here, we expanded the ER in N.

Redistribution of soil water by mature trees towards dry surface soils and uptake by seedlings in a temperate forest.

Hydraulic redistribution is considered a crucial dryland mechanism that may be important in temperate environments facing increased soil drying-wetting cycles. We investigated redistribution of soil water from deeper, moist to surface, dry soils in a mature mixed European beech forest and whether redistributed water was used by neighbouring native seedlings. In two experiments, we tracked hydraulic redistribution via (1) H labeling and (2) O natural abundance.

Reversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical Outcomes.

Background: Roux-en-Y gastric bypass may present long-term complications that require revisional surgery or even reversal to normal anatomy. Data on the indications, surgical technique, and outcomes of RYGB reversal remain scarce.

Methods: We identified 48 cases of RYGB reversals with complete 90-day follow-up within a multi-centric international retrospective database of elective secondary bariatric surgery.

Global Harmonization of Biosimilar Development by Overcoming Existing Differences in Regional Regulatory Requirements - Outcomes of a Descriptive Review.

Global harmonization of biosimilar developmental requirements will facilitate development leading to increased patient and societal benefits. However, there are several technical and regulatory hurdles that must be addressed to harmonize the regulatory requirements in different countries and regions. At times, there is a requirement for use of locally sourced reference product, forcing biosimilar developers to repeat analytical or clinical comparability studies against reference product batches sourced from within a given country.

Optimizing hydrophilic drug incorporation into SEDDS using dry reverse micelles: a comparative study of preparation methods.

Aim: It was the aim of this study to compare two different dry reverse micelle (RM) preparation methods for the incorporation of hydrophilic drugs into oral self-emulsifying drug delivery systems (SEDDS).

Methods: Cationic ethacridine lactate, anionic fluorescein sodium salt and the antibiotic peptide bacitracin were solubilized in RM containing sodium docusate, soy phosphatidylcholine and sorbitan monooleate in highly lipophilic oils such as squalane. In the dry addition (DA) method, drugs were directly added to empty RM in their powder form.

Renin-angiotensin-aldosterone system activation in plasma as marker for prognosis in critically ill patients with COVID-19: a prospective exploratory study.

Background: Acute respiratory distress syndrome (ARDS) associated with coronavirus infectious disease (COVID)-19 has been a challenge in intensive care medicine for the past three years. Dysregulation of the renin-angiotensin system (RAS) is linked to COVID-19, but also to non-COVID-19 ARDS. It is still unclear whether changes in the RAS are associated with prognosis of severe COVID-19.

Epilepsy and employment: A qualitative interview study with heads of human resources and occupational physicians in Austria - A call for legislative optimization according to the WHO Intersectoral Global Action Plan.

Objective: People with epilepsy (PWEs) often face difficulties in obtaining or keeping employment. To determine the views on this topic of the heads of human resources (HHRs) and occupational physicians (OCPs).

Method: Twelve HHRs and five OCPs underwent a telephone interview concerning the opportunities and limitations of job applications for PWEs.

Treatment of Venous Thromboembolism with Edoxaban over 18 Months: Results from ETNA-VTE Europe.

Background:  The benefits and risks of extending anticoagulant treatment beyond the first 3 to 6 months in patients with venous thromboembolism (VTE) in clinical practice are not well understood.

Methods:  ETNA-VTE Europe is a prospective, noninterventional, post-authorization study in unselected patients with VTE treated with edoxaban in eight European countries for up to 18 months. Recurrent VTE, major bleeding, and all-cause death were the primary study outcomes.

The parent-child relationship and child shame and guilt: A meta-analytic systematic review.

Empirical findings on the associations of positive and dysfunctional parent-child relationship (PPCR/DPCR) characteristics with child shame, adaptive guilt, and maladaptive guilt were synthesized in six meta-analyses. The 65 included samples yielded 633 effect sizes (N = 19,144; M = 15.24 years; 59.

Reference Ranges for Cerebral Oxygenation in Neonates During Immediate Transition After Birth: Differences Between Devices.

Aim: The aim was to define reference ranges for cerebral oxygen saturation (crSO-ROOT) during immediate transition after birth in stable neonates.

Methods: In a prospective observational study, the crSO-ROOT was continuously measured in neonates during the first 15 min after birth. The neonatal sensor was placed on the head and fixed with a bandage.

Smartphone application-based augmented reality for pre-clinical dental implant placement training: a pilot study.

Purpose: Precise implant placement is essential for optimal functional and aesthetic outcomes. Digital technologies, such as computer-assisted implant surgery (CAIS), have improved implant outcomes. However, conventional methods such as static and dynamic CAIS (dCAIS) require complex equipment.

[Pre-implementation of electronic patient-reported outcomes at reference centers for head and neck oncology : A roadmap towards patient-centered digitalization].

Background: Electronically captured patient reports (electronic patient-reported outcomes, ePROs) are digital questionnaires filled out by cancer patients. Despite indications of improved clinical care, the integration of ePROs into clinical head and neck oncology is uncharted territory.

Objective: This work outlines the implementation process for ePROs at the University Hospital for Otorhinolaryngology at the Medical University of Innsbruck (ENT Innsbruck).