A Multiyear Longitudinal Harmonization Study of Quality Controls in Mass Spectrometry Proteomics Core Facilities.

Quality control procedures play a pivotal role in ensuring the reliability and consistency of data generated in mass spectrometry-based proteomics laboratories. However, the lack of standardized quality control practices across laboratories poses challenges for data comparability and reproducibility. In response, we conducted a harmonization study within proteomics laboratories of the Core for Life alliance with the aim of establishing a common quality control framework, which facilitates comprehensive quality assessment and identification of potential sources of performance drift.

The Role of Different Modalities of Regenerative Therapies in the Treatment of Erectile Dysfunction: A Global Survey and Global Andrology Forum Expert Recommendations.

Purpose: There is increased interest in regenerative therapies (RTs) to treat erectile dysfunction (ED). However, the need for society's guidelines has led to varied practices. This study aims to investigate current global practices, address the heterogeneity in treatment protocols and evaluations, and establish expert recommendations in clinical practice.

Association of Serum Afamin Concentrations With Kidney Failure in Patients With CKD: Findings From the German CKD Cohort Study.

Rationale & Objective: Afamin is a vitamin E-binding glycoprotein primarily expressed in liver and kidney. This study investigated whether serum afamin concentrations are associated with kidney function and incident kidney failure.

Study Design: Prospective cohort study with 6.

Radiological Outcome in Reverse Shoulder Arthroplasty does not correlate with patient satisfaction or quality of life.

Background: While outcomes following reverse shoulder arthroplasty (rTSA) have often been gauged through radiological assessments focusing on prosthesis position, there is increasing recognition of patient-reported outcomes, particularly satisfaction, as indicators of surgical success. The objective of this study was to correlate radiological findings with clinical outcomes, patient satisfaction, and health-related quality of life (HRQoL).

Materials And Methods: A retrospective evaluation was conducted on patients following rTSA at a minimum of two years postoperatively.

The effect of pipette- and laser-induced blastocyst collapse before vitrification on their re-expansion and clinical outcome after warming.

Research Question: What are the effects of pipette- versus laser-assisted artificial blastocyst collapse (ABC) on the morphokinetics of warmed blastocyst re-expansion, and what is the potential effect on treatment outcomes?

Design: Surplus blastocysts were extracted from 203 patients. These were divided into three groups: study group A, artificial collapsed by the aspiration of blastocoel fluid with a pipette; study group B, trophectoderm opened with a laser pulse; control group, no manipulation before vitrification was performed. During the 5-year study period, 257 associated single-warm blastocyst transfers were scheduled.

Framing wellbeing and societal challenge mechanisms via distinct outcomes of art experience? A brief revisit to the VIMAP.

In this brief contribution-happily afforded by the 20th anniversary of Physics of Life Reviews-we take the opportunity to reflect on our earlier published paper, which had introduced a theoretical framework, the VIMAP (Vienna Integrated Model of (Top-Down and Bottom-up processes in) Art Perception; (Pelowski et al., [1])) that has come to represent a major basis for organizing, anticipating, and empirically investigating the nuanced, multivariate visual art experience. We look back at the original model and its hypotheses, especially as these regard distinct "outcomes," which we had argued may provide a superstructure of supraordinate, shared varieties of art experience detected across individual meetings of viewer, context, and artworks.

The Prognostic Quality of Risk Prediction Models to Assess the Individual Breast Cancer Risk in Women: An Overview of Reviews.

Purpose: Breast cancer is the most common cancer among women globally, with an incidence of approximately two million cases in 2018. Organised age-based breast cancer screening programs were established worldwide to detect breast cancer earlier and to reduce mortality. Currently, there is substantial anticipation regarding risk-adjusted screening programs, considering various risk factors in addition to age.

Polymer Thermophoresis by Mesoscale Simulations.

We employ mesoscopic simulations to study the thermophoretic motion of polymers in a solvent via multiparticle collision dynamics (MPCD). As the usual solvent-monomer collision rules employed in MPCD involving polymers fail to cause thermophoresis, we extend the technique by introducing explicit solvent-monomer interactions, while the solvent molecules remain ideal with respect to one another. We find that with purely repulsive polymer-solvent interaction, the polymer exhibits thermophilic behavior, whereas to display thermophobic behavior, the polymer-solvent potential requires the presence of attractions between solvent particles and monomers, in accordance with previous experimental findings.

What about spiritual needs? Care robotics and spiritual care.

Health is a multidimensional phenomenon encompassing physical, mental, social, and spiritual aspects. Therefore, it is only logical that good care should be holistic and include all these dimensions. However, when examining the current field of health and care robotics, the spiritual aspect is notably neglected.

Launching Stealth AutoGuide robot for stereotactic biopsy procedures in a neurosurgical centre: learning curve and workflow optimization.

Background: Accurate histological analysis is crucial for confirming intracerebral neoplasia due to the diverse array of potential diagnoses presented by imaging. In the realm of biopsy techniques, the use of robot-based systems is on the rise, primarily owing to their heightened targeting accuracy. The objective of this study was to elucidate the practicality, learning curve and workflow associated with robot-guided biopsies upon their introduction to a neurosurgical centre.

EEG channel and feature investigation in binary and multiple motor imagery task predictions.

Introduction: Motor Imagery (MI) Electroencephalography (EEG) signals are non-stationary and dynamic physiological signals which have low signal-to-noise ratio. Hence, it is difficult to achieve high classification accuracy. Although various machine learning methods have already proven useful to that effect, the use of many features and ineffective EEG channels often leads to a complex structure of classifier algorithms.

Adoption of Digital Therapeutics in Europe.

Digital therapeutics (DTx) are an emerging medical therapy comprising evidence-based interventions that are regulatory approved for patient use, or are under development, for a variety of medical conditions, including hypertension, cancer, substance use disorders and mental disorders. DTx have significant potential to reduce the overall burden on healthcare systems and offer potential economic benefits. There is currently no specific legal regulation on DTx in the EU.

A Cross-Sectional Study Comparing Patient Information Guides Generated by ChatGPT and Google Gemini for Common Radiological Procedures.

Introduction: Artificial intelligence (AI) plays a significant role in creating brochures on radiological procedures for patient education. Thus, this study aimed to evaluate the responses generated by ChatGPT (San Francisco, CA: OpenAI) and Google Gemini (Mountain View, CA: Google LLC) on abdominal ultrasound, abdominal CT scan, and abdominal MRI.

Methodology: A cross-sectional original research was conducted over one week in June 2024 to evaluate the quality of patient information brochures produced by ChatGPT 3.

Posterolateral Knee Ligament Reconstruction Using the Arciero Technique Provides Greater Rotational Stability Than the Modified Larson Technique: A Biomechanical Study.

Background: It is still unknown if the double-femoral tunnel technique (Arciero [ARC]) provides better stability as compared with the single-femoral tunnel technique (modified Larson [LAR]) in posterolateral corner reconstruction. The ideal angle of fixation of the popliteofibular strand in ARC is also unknown.

Hypotheses: The ARC provides greater external rotation (ER) stability than the LAR (hypothesis 1); there is no difference in varus rotation (VR) stability between LAR and ARC (hypothesis 2); and femoral fixation of the popliteofibular strand at 60° during the ARC leads to greater ER stability than fixation at 30° or 90° of knee flexion (hypothesis 3).

Clinical remission in patients with severe eosinophilic asthma treated with mepolizumab: A analysis of RELIght study.

Remission of asthma can occur as part of the natural history of the disease; however, the use of biologics can result in disease remission in some patients. In this post hoc analysis of the RELIght study, we aimed to evaluate clinical remission in real life among patients treated with mepolizumab, to detect possible differences between "remitters" and "nonremitters," and to evaluate possible predictors of remission. Clinical remission was defined as the absence of asthma exacerbations, discontinuation of oral corticosteroids (OCS), achievement of asthma control (Asthma Control Test [ACT] ≥ 20), and stable or improved lung function.

Improving small-scale cultivation of Spodoptera frugiperda 9 cells by silanizing glassware.

Cultivating insect cells in glass vessels can be challenging. Due to uncontrolled cell adhesion and associated cell loss as well as clumping, the replication of experiments is put at risk. A cost-effective solution to improve and stabilize cultivation may be to silanize glass vessels, making them more hydrophobic and chemically inert.

Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway.

Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition.

Motivations for obtaining advance provision of medication abortion in the United States: a qualitative study.

Background: Advance provision of medication abortion, or the prescription of mifepristone and misoprostol before pregnancy occurs, is an unexplored care model aimed at expanding abortion access. We examine motivations for obtaining advance provision from the online telemedicine service, Aid Access, which supports people in the United States.

Methods: Between May and November 2023, we conducted semi-structured, in-depth interviews with 39 people who obtained advance provision between January 2022 and April 2023.

Prevention of Stroke in Intracerebral Haemorrhage Survivors with Atrial Fibrillation: Rationale and Design for PRESTIGE-AF Trial.

Adequate secondary prevention in survivors of intracerebral hemorrhage (ICH) who also have atrial fibrillation (AF) is a long-standing clinical dilemma because these patients are at increased risk of recurrent ICH as well as of ischemic stroke. The efficacy and safety of oral anticoagulation, the standard preventive medication for ischemic stroke patients with AF, in ICH patients with AF are uncertain. PRESTIGE-AF is an international, phase 3b, multi-center, randomized, open, blinded end-point assessment (PROBE) clinical trial that compared the efficacy and safety of direct oral anticoagulants (DOACs) with no DOAC (either no antithrombotic treatment or any antiplatelet drug).