Introducing subgen. a new and very small lineage sharing with () an identical, largely circum-Pacific distribution pattern.

The application of DNA data on a worldwide sampling has revolutionized the infrageneric classification of the highly diverse ectomycorrhizal genus . Based on collections made in New Zealand, East Asia and North America, this study describes a new subgenus , the ninth subgenus of . Even though BLASTn of the ITS sequences suggested affinities with species of subgenera and the phylogenetic analysis based on a five-locus DNA dataset placed the target samples in an independent major clade that is taxonomically equivalent to subgenus.

Meta-analyses of the effects of high-intensity interval training in elite athletes-part I: mean effects on various performance measures.

Introduction: Meta-analysts have found that high-intensity interval training (HIIT) improves physical performance, but limited evidence exists regarding its effects on highly trained athletes, measures beyond maximum oxygen uptake ( O), and the moderating effects of different types of HIIT. In this study, we present meta-analyses of the effects of HIIT focusing on these deficits.

Methods: The effects of 6 types of HIIT and other moderators were derived from 34 studies involving highly trained endurance and elite athletes in percent units via log-transformation from separate meta-regression mixed models for sprint, time-trial, aerobic/anaerobic threshold, peak speed/power, repeated-sprint ability, O, and exercise economy.

Assessing XEN microstent's one-year efficacy: independent of site variability.

Aim: To evaluate the short-term efficacy of XEN45 Gel Stent (XEN) implantation for primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma across two university eye clinics, aiming to assess the impact of varying center-specific protocols during the first postoperative year.

Methods: We retrospectively examined 282 patients (183 in center 1, 99 in center 2), who underwent XEN microstent implantation for uncontrolled POAG or PEX glaucoma. Parameters including intraocular pressure (IOP), IOP-lowering medication count, best corrected visual acuity (BCVA), and postoperative complications were evaluated over 12mo.

Normothermic Liver Machine Perfusion At a Large European Center -Real World Outcomes Following 238 Applications.

Objective: To report outcomes from routine clinical practice of liver transplantation (LT) following normothermic liver machine perfusion (NLMP) and compare to LT after static cold storage (SCS).

Background: NLMP is emerging as a clinical routine in LT as has recently received renewed attention, however outcomes outside of clinical trials are lacking.

Methods: All adult LT between February 2018 and January 2023 were included.

Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.

Aims: Despite receiving guideline-directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH-LHD) experience higher mortality and hospitalization rates than the general HF population. AZD3427 is a functionally selective, long-acting mimetic of relaxin, a hormone that has the potential to induce vasodilation and prevent fibrosis. In a phase 1b study conducted in patients with HF, AZD3427 demonstrated a favourable safety and pharmacokinetic profile.

A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study).

Background: Options for 'treatment-resistant bipolar depression' (TRBD) are limited. Two small, short-term, trials of pramipexole suggest it might be an option.

Aims: To evaluate the clinical effectiveness and safety of pramipexole in the management of TRBD.

In-Hospital Outcomes after Robotic Open Radical Nephroureterectomy.

To test whether the contemporary robot-assisted nephroureterectomy (RNU) is associated with more favorable in-hospital outcomes than historical RNU, relative to the same endpoints in open NU (ONU). Within the National Inpatient Sample (2008-2019), we identified RNU and ONU patients. Multivariable logistic and Poisson regression models were fitted.

Long-Term Follow-Up After the Charles Procedure: Possibilities for Minimally Invasive Reconstructive Lymphedema Surgery With Lymphaticovenous Anastomosis: A Report of Four Cases.

The Charles procedure (CP) is a potentially devastating treatment; however, in cases of an end stage of untreated or improperly treated lymphedema, it is the ultimate surgical therapy. As a life-saving solution, it quickly relieves patients with giant, hypertrophic extremities, mostly in ambulation and hygiene maintenance. Nevertheless, long-term results may disappoint both doctors and patients, who struggle with social stigma, the need for lifelong compression, massive lymphoedema in the distal parts of the feet, badly fitting shoes, excessive skin fibrosis, severe keratinization of skin-grafted surfaces, periodic lymphorrhea from the resected areas, or acute and chronic inflammation.

Auxin fluctuation and PIN polarization in moss leaf cell reprogramming.

Auxin and its PIN-FORMED (PIN) exporters are essential for tissue repair and regeneration in flowering plants. To gain insight into the evolution of this mechanism, we investigated their roles in leaves excised from Physcomitrium patens, a bryophyte known for its remarkable cell reprogramming capacity. We used various approaches to manipulate auxin levels, including exogenous application, pharmacological manipulations, and auxin biosynthesis mutants.

3D Technology for Autologous Breast Reconstruction: Increased Aesthetic Outcomes and Quality of Life Using Patient-Specific Templates.

Background: In autologous breast reconstruction accomplishing aesthetically pleasing outcomes represents an integral challenge. 3-dimensional technology may aid in accurate flap shaping and subsequent breast appearance.

Objectives: The aim of this study was to evaluate the applicability of 3-dimensional technology for surgical planning and its influence on outcomes for breast reconstruction.

Molecular Mechanisms of Response to Different Sources of Oxidative Stress.

Oxidative stress is a biological principle affecting all life on Earth and is also an important factor in the pathogen-host relationship. The pathogenic free-living amoeba has several pathways to cope with reactive oxygen species and the damage that they cause. In this study, we aimed to provide a comprehensive analysis of the amoeba's response to different sources of oxidative stress.

Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses.

Cytochrome P450 (CYP) 3A4 plays a major role in drug metabolism. Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of drug response. For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans.

Molecular profiling of BRCA1/BRCA2 gene variants in Pakistani breast cancer patients.

Objectives: To determine the frequency of genetic variants in breast cancer types 1 and 2 gene in breast cancer Pakistani patients.

Methods: The case-control study was conducted at the Islamic International Medical College and Pakistan Railway Hospital, Rawalpindi, Pakistan, from October 2022 to August 2023, and comprised females with breast cancer in group A, with an age range of 23-83 years (mean 51.9 ± 10.

Navigating life's twists and turns: characteristics of life events across adulthood.

This study examines whether there are age-related differences in the experience of life events across adulthood. We hypothesized that older adults would report life events that are less anticipated, less normative, less controllable, less positive, and more strenuous than younger adults due to increasing developmental losses and decreasing gains. We investigated how age (linear, quadratic, and cubic) relates to life-event characteristics by comparing different events and analyzing the same events across individuals, to distinguish between the effects observed across life events and those that emerge after accounting for the specific life event in question.

Computational frameworks transform antagonism to synergy in optimizing combination therapies.

While drug combinations are increasingly important in disease treatment, predicting their therapeutic interactions remains challenging. This review systematically analyzes computational methods for predicting drug combination effects through multi-omics data integration. We comprehensively assess key algorithms including DrugComboRanker and AuDNNsynergy, and evaluate integration approaches encompassing kernel regression and graph networks.

The influence of prosthetic treatments and implant-supported prostheses on posterior mandibular ridge atrophy: a retrospective cohort study.

Aims: Bone preservation is a requirement for long-term stability of dental prostheses, which is all the more important in the posterior mandible, given the particular challenges these areas pose to prosthetic treatment. The objective was to investigate the implications of different prostheses on the atrophy of posterior alveolar bone after tooth loss.

Materials And Methods: A total of 457 treatment cases were retrieved from the medical documentation and information network.

Trajectory of Cardiogenic Dementia: A New Perspective.

The functions of the heart and brain are closely linked and essential to support human life by the heart-brain axis, which is a complex interconnection between the heart and brain. Also, cardiac function and cerebral blood flow regulate the brain's metabolism and function. Therefore, deterioration of cardiac function may affect cognitive function and may increase the risk of dementia.

Mechanisms of Lipid-Associated Macrophage Accrual in Metabolically Stressed Adipose Tissue.

Adipose tissue (AT) inflammation, a hallmark of the metabolic syndrome, is triggered by overburdened adipocytes sending out immune cell recruitment signals during obesity development. An AT immune landscape persistent throughout weight loss and regain constitutes an immune-obesogenic memory that hinders long-term weight loss management. Lipid-associated macrophages (LAMs) are emerging as major players in diseased, inflamed metabolic tissues and may be key contributors to an obesogenic memory in AT.

Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial.

Background: Obesity during pregnancy is related to fetal overgrowth. Effective interventions that can mitigate this risk are needed.

Objectives: This study aimed to investigate the effect of a lifestyle intervention for pregnant women with obesity on fetal growth trajectories.

Heart rate and salivary cortisol as indicators of arousal and synchrony in clients, therapy horses and therapist in equine-assisted therapy.

Background: This exploratory study aimed to analyse physiological interaction processes in equine-assisted-therapy (EAT) between client, therapy horse and therapist.

Methods: We measured heart rate (HR), heart rate variability (HRV) and cortisol levels before, during and after a standardized therapy session and a control condition in one therapist, four therapy horses and ten female clients in emerging adulthood (Mn = 21.8 years, SD = 3.

Nano-zirconium-silicate solid-phase extraction method for the rapid quantification of pyrrolizidine alkaloids from plant extracts by UHPLC-QTOF-MS.

The aim of this work was to develop and validate a rapid dispersive-solid-phase extraction method for the quantification of pyrrolizidine alkaloids (PA) from plant extracts. The method was focused on the significant removal of the intricate matrix to ensure good sensitivity for the subsequent instrumental analysis of PA. This was achieved by employing nano-zirconium silicate (NZS) as a dispersive-SPE sorbent.

Automation of on-site microbial water quality monitoring from source to tap: Challenges and perspectives.

Ensuring the provision of safe drinking water necessitates thorough monitoring of microbial water quality. While traditional culture-based enumeration of bacterial indicators has served as the gold standard in compliance monitoring since the late 19th century, recent advancements in microbial sensor technology, driven by automation and digitalization, are revolutionizing on-site monitoring capabilities. These innovations offer unparalleled potential for automated, high temporal frequency monitoring with remote, real-time data transmission.