Predictors of pelvic acceleration during treadmill running across various stride frequency conditions.

Pelvic running injuries often require extensive rehabilitation and pelvic girdle pain is a barrier to running engagement in population sub-groups, such as perinatal women. However, exploration into how external pelvic loading may be altered during running is limited. This study assessed which biomechanical variables influence changes in external peak pelvic acceleration during treadmill running, across various stride frequency conditions.

Transcriptomic Landscape of Polypide Development in the Freshwater Bryozoan Cristatella mucedo: From Budding to Degeneration.

Colonial invertebrates consist of iterative semi-autonomous modules (usually termed zooids) whose lifespan is significantly shorter than that of the entire colony. Typically, module development begins with budding and ends with degeneration. Most studies on the developmental biology of colonial invertebrates have focused on blastogenesis, whereas the changes occurring throughout the entire zooidal life were examined only for a few tunicates.

Lettuce fortification through vitamin B-producing bacteria - proof of concept study.

Background: Vitamin B (cobalamin) can be produced de novo only by certain bacteria and archaea. It plays a crucial role in the health of animals and humans, which obtain it only through diet, mainly from animal products. This study aimed to identify endophytic bacterial strains capable of synthesizing vitamin B and enriching edible plants with it as a potential solution for vitamin B deficiency in vegetarians, vegans, and people with poor diets.

Departing from standard practices: Strategic application of value engineering in the anatomy laboratory to enhance formaldehyde extraction using high-impact, low-cost, and low-maintenance solutions.

This study describes the process of developing a high-impact, low-cost, and low-maintenance air ventilation system for anatomy facilities. It employed the strategic application of Value Engineering (VE), assuring that the air ventilation system meets contemporary threshold limit values (TLVs) for formaldehyde in the working zone of dissection tables. A creative-innovative construction methodology was used, combining the Theory of Inventive Problem Solving (TRIZ/TIPS) and VE for an anatomy laboratory air ventilation concept.

Electrochemical Fluorination of Organic Compounds Using a Hexafluorosilicate Salt as an Inexpensive and Widely Available Fluorine Source.

The introduction of fluorine into organic molecules is of the utmost importance in the preparation of active pharmaceutical ingredients (APIs). While a wide range of fluorine sources for organic synthesis have been used over the past decades, the associated safety risks, cost, or environmental impact are still serious limitations. Hexafluorosilicate salts are one of the most inexpensive and readily available sources of nucleophilic fluorine, but they have so far not been used in organic synthesis.

The concepts of irreversibility and reversibility in research on anthropogenic environmental changes.

The concept of "irreversibility" and its counterpart "reversibility" have become prominent in environmental and ecological research on human-induced changes, thresholds, climate tipping points, ecosystem degradation, and losses in the cryosphere and biosphere. Through a systematic literature review, we show that in these research fields, these notions are not only descriptive terms, but can have different semantic functions and normative aspects. The results suggest that, in the context of environmental and ecological research the concepts of irreversibility and reversibility have taken on additional usages in comparison to their contexts in theoretical thermodynamics and mechanics.

First Observation of a Nuclear Recoil Peak at (100eV) with Crab: A Potential New Calibration Standard for Cryogenic Detectors.

Any experiment aiming to measure rare events, like Coherent Elastic neutrino-Nucleus Scattering (CE NS) or hypothetical Dark Matter scattering, via nuclear recoils in cryogenic detectors relies crucially on a precise detector calibration at sub-keV energies. The Crab collaboration developed a new calibration technique based on the capture of thermal neutrons inside the target crystal. Together with the Nucleus experiment, first measurements with a moderated Cf neutron source and a cryogenic detector were taken.

Examining the prevention approach in National Dementia Plans from European and North American countries.

Objectives: This paper aims to provide a comprehensive review of National Dementia Plans (NDPs) from selected European and North American countries, focusing on the distinct prevention strategies outlined and the approaches employed for reducing dementia risk.

Method: The sample consisted of 16 NDPs from Austria, Canada, Finland, France, Germany, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Malta, the Netherlands, Spain, Switzerland, the UK, and the USA. These NDPs were retrieved from the Alzheimer's Disease International (ADI) database, with regular updates checked on official governmental websites.

Management of patients with venous thromboembolism and a high recurrence risk estimated by the Vienna Prediction Model: a prospective cohort study.

Background: The Vienna Prediction Model (VPM) identifies patients with a first unprovoked deep vein thrombosis of the leg and/or pulmonary embolism who have a low recurrence risk and may, therefore, not benefit from extended-phase anticoagulation.

Objectives: The aim of this study was to evaluate patients with a predicted high risk of recurrent venous thromboembolism (VTE).

Methods And Results: We prospectively followed 266 patients in whom the VPM had predicted a recurrence risk of more than 5.

A transdisciplinary, comparative analysis reveals key risks from Arctic permafrost thaw.

Permafrost thaw poses diverse risks to Arctic environments and livelihoods. Understanding the effects of permafrost thaw is vital for informed policymaking and adaptation efforts. Here, we present the consolidated findings of a risk analysis spanning four study regions: Longyearbyen (Svalbard, Norway), the Avannaata municipality (Greenland), the Beaufort Sea region and the Mackenzie River Delta (Canada) and the Bulunskiy District of the Sakha Republic (Russia).

Confocal Raman Microscopy with Adaptive Optics.

Confocal Raman microscopy, a highly specific and label-free technique for the microscale study of thick samples, often presents difficulties due to weak Raman signals. Inhomogeneous samples introduce wavefront aberrations that further reduce these signals, requiring even longer acquisition times. In this study, we introduce Adaptive Optics to confocal Raman microscopy for the first time to counteract such aberrations, significantly increasing the Raman signal and image quality.

Mechanisms of aortic dissection: From pathological changes to experimental and models.

Aortic dissection continues to be responsible for significant morbidity and mortality, although recent advances in medical data assimilation and in experimental and models have improved our understanding of the initiation and progression of the accumulation of blood within the aortic wall. Hence, there remains a pressing necessity for innovative and enhanced models to more accurately characterize the associated pathological changes. Early on, experimental models were employed to uncover mechanisms in aortic dissection, such as hemodynamic changes and alterations in wall microstructure, and to assess the efficacy of medical implants.

On the directional asymptotic approach in optimization theory.

As a starting point of our research, we show that, for a fixed order , each local minimizer of a rather general nonsmooth optimization problem in Euclidean spaces is either M-stationary in the classical sense (corresponding to stationarity of order 1), satisfies stationarity conditions in terms of a coderivative construction of order , or is asymptotically stationary with respect to a critical direction as well as order in a certain sense. By ruling out the latter case with a constraint qualification not stronger than directional metric subregularity, we end up with new necessary optimality conditions comprising a mixture of limiting variational tools of orders 1 and . These abstract findings are carved out for the broad class of geometric constraints and , and visualized by examples from complementarity-constrained and nonlinear semidefinite optimization.

Introducing subgen. a new and very small lineage sharing with () an identical, largely circum-Pacific distribution pattern.

The application of DNA data on a worldwide sampling has revolutionized the infrageneric classification of the highly diverse ectomycorrhizal genus . Based on collections made in New Zealand, East Asia and North America, this study describes a new subgenus , the ninth subgenus of . Even though BLASTn of the ITS sequences suggested affinities with species of subgenera and the phylogenetic analysis based on a five-locus DNA dataset placed the target samples in an independent major clade that is taxonomically equivalent to subgenus.

Meta-analyses of the effects of high-intensity interval training in elite athletes-part I: mean effects on various performance measures.

Introduction: Meta-analysts have found that high-intensity interval training (HIIT) improves physical performance, but limited evidence exists regarding its effects on highly trained athletes, measures beyond maximum oxygen uptake ( O), and the moderating effects of different types of HIIT. In this study, we present meta-analyses of the effects of HIIT focusing on these deficits.

Methods: The effects of 6 types of HIIT and other moderators were derived from 34 studies involving highly trained endurance and elite athletes in percent units via log-transformation from separate meta-regression mixed models for sprint, time-trial, aerobic/anaerobic threshold, peak speed/power, repeated-sprint ability, O, and exercise economy.

Assessing XEN microstent's one-year efficacy: independent of site variability.

Aim: To evaluate the short-term efficacy of XEN45 Gel Stent (XEN) implantation for primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma across two university eye clinics, aiming to assess the impact of varying center-specific protocols during the first postoperative year.

Methods: We retrospectively examined 282 patients (183 in center 1, 99 in center 2), who underwent XEN microstent implantation for uncontrolled POAG or PEX glaucoma. Parameters including intraocular pressure (IOP), IOP-lowering medication count, best corrected visual acuity (BCVA), and postoperative complications were evaluated over 12mo.

Normothermic Liver Machine Perfusion At a Large European Center -Real World Outcomes Following 238 Applications.

Objective: To report outcomes from routine clinical practice of liver transplantation (LT) following normothermic liver machine perfusion (NLMP) and compare to LT after static cold storage (SCS).

Background: NLMP is emerging as a clinical routine in LT as has recently received renewed attention, however outcomes outside of clinical trials are lacking.

Methods: All adult LT between February 2018 and January 2023 were included.

Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.

Aims: Despite receiving guideline-directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH-LHD) experience higher mortality and hospitalization rates than the general HF population. AZD3427 is a functionally selective, long-acting mimetic of relaxin, a hormone that has the potential to induce vasodilation and prevent fibrosis. In a phase 1b study conducted in patients with HF, AZD3427 demonstrated a favourable safety and pharmacokinetic profile.

A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study).

Background: Options for 'treatment-resistant bipolar depression' (TRBD) are limited. Two small, short-term, trials of pramipexole suggest it might be an option.

Aims: To evaluate the clinical effectiveness and safety of pramipexole in the management of TRBD.

In-Hospital Outcomes after Robotic Open Radical Nephroureterectomy.

To test whether the contemporary robot-assisted nephroureterectomy (RNU) is associated with more favorable in-hospital outcomes than historical RNU, relative to the same endpoints in open NU (ONU). Within the National Inpatient Sample (2008-2019), we identified RNU and ONU patients. Multivariable logistic and Poisson regression models were fitted.

Long-Term Follow-Up After the Charles Procedure: Possibilities for Minimally Invasive Reconstructive Lymphedema Surgery With Lymphaticovenous Anastomosis: A Report of Four Cases.

The Charles procedure (CP) is a potentially devastating treatment; however, in cases of an end stage of untreated or improperly treated lymphedema, it is the ultimate surgical therapy. As a life-saving solution, it quickly relieves patients with giant, hypertrophic extremities, mostly in ambulation and hygiene maintenance. Nevertheless, long-term results may disappoint both doctors and patients, who struggle with social stigma, the need for lifelong compression, massive lymphoedema in the distal parts of the feet, badly fitting shoes, excessive skin fibrosis, severe keratinization of skin-grafted surfaces, periodic lymphorrhea from the resected areas, or acute and chronic inflammation.

Auxin fluctuation and PIN polarization in moss leaf cell reprogramming.

Auxin and its PIN-FORMED (PIN) exporters are essential for tissue repair and regeneration in flowering plants. To gain insight into the evolution of this mechanism, we investigated their roles in leaves excised from Physcomitrium patens, a bryophyte known for its remarkable cell reprogramming capacity. We used various approaches to manipulate auxin levels, including exogenous application, pharmacological manipulations, and auxin biosynthesis mutants.

3D Technology for Autologous Breast Reconstruction: Increased Aesthetic Outcomes and Quality of Life Using Patient-Specific Templates.

Background: In autologous breast reconstruction accomplishing aesthetically pleasing outcomes represents an integral challenge. 3-dimensional technology may aid in accurate flap shaping and subsequent breast appearance.

Objectives: The aim of this study was to evaluate the applicability of 3-dimensional technology for surgical planning and its influence on outcomes for breast reconstruction.