Reallocating Time Between 24-h Movement Behaviors for Obesity Management Across the Lifespan: A Pooled Data Meta-Analysis of More Than 9800 Participants from Seven Countries.

Background: The distribution of time across physical activity, sedentary behaviors, and sleep appears to be essential for the management of obesity. However, the impact of reallocating time among these behaviors, collectively known as 24-h movement behaviors, remains underexplored.

Objective: This study examines the theoretical effects of reallocating time between 24-h movement behaviors on obesity indicators across different age groups.

Mortality associated with moderate and severe mitral regurgitation in 608 570 men and women undergoing echocardiography.

Background: Although the prognostic implications of severe mitral regurgitation (MR) are well recognised, they are less clear in moderate MR. We therefore explored the prognostic impact of both moderate and severe MR within the large National Echocardiography Database Australia cohort.

Methods: Echocardiography reports from 608 570 individuals were examined using natural language processing to identify MR severity and leaflet pathology.

Assessment of an eye-tracking tool to discriminate between concussed and not concussed professional male rugby players: a cohort study.

Concussion is a common injury in rugby union ('rugby') and yet its diagnosis is reliant on clinical judgment. Oculomotor testing could provide an objective measure to assist with concussion diagnosis. NeuroFlex® evaluates oculomotor function using a virtual-reality headset.

Early Maladaptive Schemas and Dissociative Symptoms: A Systematic Review and Meta-Analysis.

Background: Dissociation is an underresearched and important clinical construct associated with impaired functioning and poor quality of life. Improved understanding of the modifiable correlates of dissociation can inform early detection and effective treatments. The aim of this systematic review and meta-analysis was to synthesise the evidence on the associations between dissociative symptoms and early maladaptive schemas (EMSs).

Blockchain Integration in UAV Networks: Performance Metrics and Analysis.

Blockchain technology has revolutionized the management of Unmanned Aerial Vehicle (UAV) networks by enhancing security, enabling decentralized control, and improving operational efficiency. This study assesses the efficiency of private blockchain architectures in UAV networks, specifically examining important performance metrics such as throughput, latency, scalability, and packet size. Furthermore, we evaluate the effectiveness of UAV networks when integrating private blockchain technologies, focusing particularly on key performance indicators such as area, altitude, and data rate.

Effects of Synbiotic Supplementation on Bone and Metabolic Health in Caucasian Postmenopausal Women: Rationale and Design of the OsteoPreP Trial.

Background/objectives: Correction of decreased diversity of the gut microbiome, which is characteristic of menopause, by supplementation with a synbiotic may attenuate or prevent dysbiosis processes and preserve bone mass. We describe the rationale and design of the OsteoPreP trial aimed at evaluating the effects of 12 months of supplementation with a synbiotic on bone and metabolic health in postmenopausal Caucasian women.

Methods: This is a randomized, double-blinded, placebo-controlled trial among 160 Caucasian, postmenopausal women with no current diagnosis of osteoporosis or supplementation with pro- or prebiotics, and no medical treatment affecting bone turnover.

Sirtuin Proteins and Memory: A Promising Target in Alzheimer's Disease Therapy?

Sirtuins (SIRTs), nicotine adenine dinucleotide (+)-dependent histone deacetylases, have emerged as critical regulators in many signalling pathways involved in a wide range of biological processes. Currently, seven mammalian SIRTs have been characterized and are found across a number of cellular compartments. There has been considerable interest in the role of SIRTs in the brain due to their role in a plethora of metabolic- and age-related diseases, including their involvement in learning and memory function in physiological and pathophysiological conditions.

Genetics, Fitness and Left Ventricular Remodeling: The Current State of Play.

Cardiorespiratory fitness (CRF) exists on a spectrum and is driven by a constellation of factors including genetic and environmental differences. This results in wide inter-individual variation in baseline CRF and the ability to improve CRF with regular endurance exercise training. As opposed to monogenic conditions, CRF is described as a complex genetic trait as it is believed to be influenced by multiple common genetic variants in addition to exogenous factors.

Developmental coordination disorder subtypes also vary in the pattern of behavioral and emotional problems.

Background: Behavioral and emotional problems in children with Developmental Coordination Disorder (DCD) are well documented. However, the heterogeneity of this group has been largely overlooked. Addressing this gap is important to develop individually-tailored interventions.

Older rural women's pre-visit planning and involvement in South Australian general practices: A candidacy theory perspective.

Objective: To explain older rural women's participation in clinical decision-making with GPs and explore factors associated with their pre-visit planning and involvement in treatment processes.

Methods: A sequential, theory-driven mixed-method study was conducted. Women aged 65 years or above who had visited a GP three months prior were recruited from five rural towns in South Australia through the local Rotary Club.

Experiences of participation in daily life of adolescents and young adults with cerebral palsy: A scoping review.

Aim: To synthesize the experiences of 15- to 34-year-olds with cerebral palsy (CP) as they participate in key life situations of young adulthood.

Method: A mixed-methods scoping review was undertaken and six electronic databases searched (January 2001 to August 2023). Participation foci and thematic outcomes were mapped to the International Classification of Functioning, Disability and Health.

Nurses' Perspectives on the Use of Prophylactic Dressings to Prevent Pressure Injury: A Qualitative Study.

Aim: To understand, from a nursing perspective, factors affecting the use of prophylactic dressings to prevent pressure injuries in acute hospitalised adults.

Background: Pressure injury causes harm to patients and incurs significant costs to health services. Significant emphasis is placed on their prevention.

The Role of Speed, Change of Direction, and Momentum by Position and Starting Status in Division 1 Collegiate Football Players.

Mann, JB, Cowley, N, and Weakley, J. The role of speed, change of direction, and momentum by position and starting status in Division 1 collegiate football players. J Strength Cond Res 39(1): 41-47, 2025-This study (a) investigated differences between big, mid, and skill positions in sprint and change of direction times and momentum; (b) compared starting and nonstarting athletes; and (c) investigated whether thresholds can be developed to distinguish between starting and nonstarting Division 1 collegiate football athletes.

Eyes on communication: strategies to facilitate uptake of clinical practice guidelines for implementation of eye-gaze control technology by people with cerebral palsy. A mixed methods study.

Guidelines for implementation of eye-gaze control technology by people with cerebral palsy were published in 2021. The purpose of this study was to identify barriers and facilitators clinicians perceive exist relating to use of these guidelines for eye-gaze control technology, and to explore potential resources that may be developed to support their implementation. A two-phased mixed methods explanatory sequential design was adopted.

Burden of disease scenarios by state in the USA, 2022-50: a forecasting analysis for the Global Burden of Disease Study 2021.

Background: The capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insights can facilitate effective planning, investment, and implementation strategies. Forecasting trends in disease and injury burden is not only crucial for policy makers but also garners substantial interest from the general populace and leads to a better-informed public. Through the integration of new data sources, the refinement of methodologies, and the inclusion of additional causes, we have improved our previous forecasting efforts within the scope of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to produce forecasts at the state and national levels for the USA under various possible scenarios.

Prevalence and characteristics of online child sexual victimization: Findings from the Australian Child Maltreatment Study.

Background: Online child sexual victimization is increasingly facilitated by technology, but evidence of its prevalence and characteristics remains scarce. Reliable population-based data is critical to understand the magnitude and nature of the problem, and inform evidence-based prevention.

Objective: To determine the prevalence of nonconsensual sharing of sexual images of the child by any perpetrator, and of online sexual solicitation by any adult perpetrator; and to determine the characteristics of these experiences.

Disclosure and non-disclosure of childhood sexual abuse in Australia: Results from a national survey.

Background: Little population-based evidence exists about prevalence of lifetime disclosure and non-disclosure of child sexual abuse (CSA). Evidence is lacking about disclosure by girls and women compared with boys and men, and gender diverse individuals. It is unclear if disclosure is more common in contemporary society, and if disclosure is influenced by abuse severity and perpetrator type.

"You need to be supported": An integrative review of nurses' experiences after death in neonatal and paediatric intensive care.

Background: The death of a child can have a profound impact on critical care nurses, shaping their professional practice and personal lives in diverse, enduring ways. Whilst end-of-life care is recognised as a core component of critical care nursing practice and a research priority, evidence about nurses' experiences after death in neonatal and paediatric intensive care is poorly understood.

Research Question: What is the experience of the nurse after death of a patient in neonatal and/or paediatric intensive care?

Method: Following registration with Open Science Framework, an integrative review of the empirical literature was undertaken.

Using multiplexed functional data to reduce variant classification inequities in underrepresented populations.

Background: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS).

Methods: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database.