1 results match your criteria: "AustraliaDepartment of Medical BiologyThe University of Melbourne[Affiliation]"
PUMA regulates germ cell loss and primordial follicle endowment in mice.
Reproduction
August 2014
MIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria, AustraliaThe Walter and Eliza Hall Institute of Medical ResearchMelbourne, Victoria, AustraliaDepartment of Medical BiologyThe University of Melbourne, Melbourne, Victoria, AustraliaMIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaDepartment of Anatomy and Developmental BiologyMonash University, Clayton, Victoria, AustraliaThe Walter and Eliza Hall Institute of Medical ResearchMelbourne, Victoria, AustraliaDepartment of Medical BiologyThe University of Melbourne, Melbourne, Victoria, Australia
Article Synopsis
- The study identifies BBC3 (PUMA) as a crucial protein that regulates germ cell death during ovarian development, impacting the number of primordial follicles formed.
- Disruption of the Bbc3 gene led to a significant increase in germ cell counts in female mice, resulting in a nearly doubled number of primordial follicles by postnatal day 10.
- BBC3 is essential for controlling germ cell death early in development but does not influence germ cell proliferation or the subsequent loss of germ cells during later stages.