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T Follicular Helper Cells in Transplantation.
Transplantation
August 2016
1 Department of Immunology and Infectious Disease, John Curtin School of Medical Research and Centre for Personalised Immunology, Australian National University, Canberra, Australia.2 Department of Renal Medicine, The Canberra Hospital, Canberra, Australia.3 Australian National University Medical School, Canberra, Australia.
The recently described T follicular helper (Tfh) cell is required for the production of high affinity antibody. After contact with follicular dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by direct B cell-T cell interaction and production of IL-21. This drives proliferation, differentiation, and affinity maturation of the B cells to produce plasma cells capable of secreting high-affinity antibody.
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