Scope+: An open source generalizable architecture for single-cell RNA-seq atlases at sample and cell levels.

Summary: With the recent advancement in single-cell RNA-sequencing technologies and the increased availability of integrative tools, challenges arise in easy and fast access to large collections of cell atlas. Existing cell atlas portals rarely are open sourced and adaptable, and do not support meta-analysis at cell level. Here, we present an open source, highly optimised and scalable architecture, named Scope+, to allow quick access, meta-analysis and cell-level selection of the atlas data.

TG-MS Analysis for Elemental Composition of Organic Matters and Their Structural Properties.

A novel approach for determining the elemental content of organic matter through thermal gravimetric analysis coupled online with a mass spectrometer (TG-MS) is disclosed. This method not only yields results equivalent to ASTM analysis but also provides insight into the covalent bond structure within the sample. The principle of this technique consists of the combustion of organic matter in an oxygen-enriched environment within the thermogravimetric (TG) system.

Next-Generation Desalination Membranes Empowered by Novel Materials: Where Are We Now?

Membrane desalination is an economical and energy-efficient method to meet the current worldwide water scarcity. However, state-of-the-art reverse osmosis membranes are gradually being replaced by novel membrane materials as a result of ongoing technological advancements. These novel materials possess intrinsic pore structures or can be assembled to form lamellar membrane channels for selective transport of water or solutes (e.

Water-soluble polysaccharides from Torreya grandis nuts: Structural characterization and anti-inflammatory activity.

Torreya grandis (T. grandis) nuts are widely consumed as a functional food in China. In this study, we investigated the structural characteristics of T.

High-pressure homogenization transformed salmon protein filament into micelle structure: Improvement on the stability and swallowing rheology of dysphagia-oriented salmon emulsion gels.

The aging population is stimulating increased demand for dysphagia-oriented foods, yet most current options are made of ultra-processed macronutrients and lack high-quality protein and ω-3 fatty acids. This study explores the use of whole salmon fillets as a myofibrillar protein source to stabilize salmon backbone oil, creating ω-3-rich emulsion gels (50-60 vol%) for dysphasia individuals. Two-step high-pressure homogenization (HPH; 50 MPa) improved emulsion texture, storage stability, and swallowability (IDDSI level 4) by reducing oil droplet size (from 20 to 2 μm) and increasing elastic modulus by 6-8 times and viscosity by more than 10 times.

Mantle oxidation by sulfur drives the formation of giant gold deposits in subduction zones.

Oxidation of the sub-arc mantle driven by slab-derived fluids has been hypothesized to contribute to the formation of gold deposits in magmatic arc environments that host the majority of metal resources on Earth. However, the mechanism by which the infiltration of slab-derived fluids into the mantle wedge changes its oxidation state and affects Au enrichment remains poorly understood. Here, we present the results of a numerical model that demonstrates that slab-derived fluids introduce large amounts of sulfate (S) into the overlying mantle wedge that increase its oxygen fugacity by up to 3 to 4 log units relative to the pristine mantle.

Development of a Nanobody-Alkaline Phosphatase Fusion Protein for Detection of SARS-CoV-2 Spike Protein in a Fluorescence Enzyme Immunoassay.

The continuous spread and evolution of severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) necessitate the development of convenient and rapid detection methods. In this study, we developed a fluorescence enzyme immunoassay (FEIA) based on a nanobody (Nb)-alkaline phosphatase (ALP) fusion protein for detection of SARS-CoV-2 spike protein. The genetically modified anti-SARS-CoV-2 S-RBD Nb, Nb61, gene was fused with the ALP gene sequences via a flexible linker.

Inflammatory Myofibroblastic Tumor of the Orbit: A Case Series and Literature Review.

Purpose: Orbital inflammatory myofibroblastic tumors (IMTs) are a rare tumor with intermediate biological potential. We analyzed a series of orbital IMTs to determine their unique features.

Methods: Records from patients with pathologically confirmed IMT at Beijing Tongren Hospital, Capital Medical University, between January 2004 and August 2022, were reviewed for their ocular presentation and treatment outcomes.

Asciminib add-on to imatinib demonstrates sustained high rates of ongoing therapy and deep molecular responses with prolonged follow-up in the ASC4MORE study.

Background: Up to 65% of patients with chronic myeloid leukemia (CML) who are treated with imatinib do not achieve sustained deep molecular response, which is required to attempt treatment-free remission. Asciminib is the only approved BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket. This unique mechanism of action allows asciminib to be combined with adenosine triphosphate-competitive tyrosine kinase inhibitors to prevent resistance and enhance efficacy.

Association between high-density-lipoprotein cholesterol and risk of abdominal aortic aneurysm among males and females aged 60 years and over.

Objective: Whether high-density-lipoprotein cholesterol (HDL-c) has a protective role against abdominal aortic aneurysm (AAA) development in both older males and females remains uncertain. This study aims to assess the sex-specific association between HDL-c and incident AAA in older adults from the UK Biobank.

Methods: This cohort study included 86,184 males and 95,682 females aged ≥60 years from the UK biobank.

Near telomere-to-telomere genome assembly of Mongolian cattle: implications for population genetic variation and beef quality.

Background: Mongolian cattle, a unique breed indigenous to China, represent valuable genetic resources and serve as important sources of meat and milk. However, there is a lack of high-quality genomes in cattle, which limits biological research and breeding improvement.

Findings: In this study, we conducted whole-genome sequencing on a Mongolian bull.

Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision.

Single-nucleotide variants (SNVs) are extremely prevalent in human cancers, although most of these remain clinically unactionable. The programmable RNA nuclease CRISPR-Cas13 has been deployed to specifically target oncogenic RNAs. However, silencing oncogenic SNVs with single-base precision remains extremely challenging due to the intrinsic mismatch tolerance of Cas13.

One Stone for Multiple Birds: Copolymer with Multifunctional Groups Boosts the Cycling Stability of Lithium Cobalt Oxide Cathodes at 4.5 V.

High-voltage LiCoO is a promising cathode material for ultrahigh-energy lithium-ion batteries, particularly in the commercialization of 5G technology. However, achieving long-term operational stability remains a significant challenge. Herein, a quaterpolymer additive with multiple functional groups is introduced to enhance the electrochemical performance of LiCoO cathode at 4.

How Users' Personality Traits Predict Sentiment Tendencies of User-Generated Content in Social Media: A Mixed Method of Configuration Analysis and Machine Learning.

Objective: Social media content created by users with different personality traits presents various sentiment tendencies, easily leading to irrational public opinion. This study aims to explore the relationships between users' personality traits and sentiment tendencies of user-generated content (UGC).

Method: We crawled 18,686 tweets of 1, 215 users from Twitter to figure out the relationships between personality traits and sentiment tendencies.

Barley2035: A decade vision on barley research and breeding.

Barley (Hordeum vulgare ssp. vulgare) is one of the oldest founder crops in early human civilization, and has been widely dispersed around the globe to supply human life through livestock feeding and brewing industries. It has been used in innovative research of cytogenetics, biochemistry, and genetics since the early half of the 20 century, facilitated by its mode of reproduction through self-pollination, its true diploid status which has contributed to the accumulation of a plethora of germplasm and mutant resources.

Implications of the choroid plexus in Niemann-Pick disease Type C neuropathogenesis.

Background: Niemann-Pick Disease Type C (NPC) is an ultra-rare disorder characterized by progressive psychiatric and neurologic manifestations, with late infantile, juvenile, and adolescent/adult presentations. We examined morphological properties of the choroid plexus, a protective blood-cerebrospinal fluid barrier, in NPC, and their relationship with neurodegeneration, clinical status, and circulatory markers. This study also determined whether choroid plexus morphology differentiates between NPC and more prevalent illnesses, schizophrenia (SZ) and bipolar disorder (BD), which have overlapping psychiatric symptoms with adolescent and adult-onset NPC and are associated with misdiagnosis.

Selective adsorption of copper by amidoxime modified low-temperature biochar: Performance and mechanism.

Biochars prepared at 300-700 °C were functionalized with amidoxime groups to evaluate their selective adsorptive removal capabilities towards Cu(II), Cd(II), and Pb(II). The results show that the amidoxime modification significantly enhanced the the Cu(II) adsorption capacity of the biochar prepared at 300 °C (AOBC300) by 1.6 times, reaching 0.

Anionic Doping in Layered Transition Metal Chalcogenides for Robust Lithium-Sulfur Batteries.

Lithium-sulfur batteries (LSBs) are among the most promising next-generation energy storage technologies. However, a slow Li-S reaction kinetics at the LSB cathode limit their energy and power densities. To address these challenges, this study introduces an anionic-doped transition metal chalcogenide as an effective catalyst to accelerate the Li-S reaction.

Reversible Carrier Modulation in InP Nanolasers by Ionic Liquid Gating with Low Energy Consumption.

Nanoscale light sources are demanded vigorously due to rapid development in photonic integrated circuits (PICs). III-V semiconductor nanowire (NW) lasers have manifested themselves as indispensable components in this field, associated with their extremely compact footprint and ultra-high optical gain within the 1D cavity. In this study, the carrier concentrations of indium phosphide (InP) NWs are actively controlled to modify their emissive properties at room temperature.

Research of digital management on sport: An analysis of bibliometrics using CiteSpace Software.

Digital management on sport (DMS) has become a hot topic around sports management. However, a more comprehensive and in-depth investigation into the structure and progression of this field is necessary. We used CiteSpace software to conduct a bibliometric analysis, revealing dynamic patterns in the evolution of co-citation, collaboration, and keyword co-occurrence within this field.

Non-Myopic Beam Scheduling for Multiple Smart-Target Tracking in Phased Array Radar Networks.

This paper addresses beam scheduling for tracking multiple smart targets in phased array radar networks, aiming to mitigate the performance degradation in previous myopic scheduling methods and enhance the tracking performance, which is measured by a discounted cost objective related to the tracking error covariance (TEC) of the targets. The scheduling problem is formulated as a restless multi-armed bandit problem, where each bandit process is associated with a target and its TEC states evolve with different transition rules for different actions, i.e.

CASSAD: Chroma-Augmented Semi-Supervised Anomaly Detection for Conveyor Belt Idlers.

Idlers are essential to conveyor systems, as well as supporting and guiding belts to ensure production efficiency. Proper idler maintenance prevents failures, reduces downtime, cuts costs, and improves reliability. Most studies on idler fault detection rely on supervised methods, which depend on large labelled datasets for training.

Mechanisms of anthraquinone dye Vat Blue 4 biodegradation by Pseudomonas aeruginosa WYT and genotoxicity assessment of its transformation products.

Dye biodegradation products may cause genotoxicity, raising concerns about the safety of bioremediated water. The underlying biotransformation mechanism and related genotoxicity during anthraquinone degradation remain unclear. In this study, we employed Pseudomonas aeruginosa WYT (PaWYT) to investigate the biotransformation of Vat Blue 4 (VB4), a dye with a typical anthraquinone structure and low bioavailability.

In-situ generation and stabilization of gas bubbles for multiphase catalysis.

Introducing stable gas bubbles in liquid is important for the industrial synthesis of chemicals and intermediates via multiphase reactions because of limited solubility of gaseous reactants such as H and O. Herein, a bubble-stabilized system is constructed via in-situ nucleation of bubbles at the surfaces of various polymer nanofibers that circumvents the repulsive interactions between gas-liquid interfaces and nanofibers. During bubble growth processes, nanofibers are self-assembled and interwoven to build spatial nanofiber network surrounding bubbles, firmly trapping bubbles in the liquid phase.

The relationship between lifecourse traumatic events and pain in an older rural South African population: A cross-sectional study.

Background: Pain in older adults is an increasing concern in low- and middle-income countries (LMICs), with literature suggesting an association with past traumatic events (TEs) in high-income settings. We aim to investigate this relationship in a population-representative sample of older adults with high burden of TEs in a rural South African community.

Methods: The Health and Aging in Africa: A longitudinal Study of an INDEPTH Community in South Africa (HAALSI) study collected data pain intensity, using the Brief Pain Inventory, and TEs with a 16-item questionnaire, from 2411 participants aged 40-79 in 2014-15.