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Comparison of 2 weight-loss diets of different protein content on bone health: a randomized trial.

Am J Clin Nutr

November 2013

From Food and Nutritional Sciences, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia (DJ, JK, and PC); the Centre of Clinical Research Excellence in Human Nutrition, University of Adelaide, Adelaide, Australia (DJ and PC); the Endocrinology Department, The Queen Elizabeth Hospital, Adelaide, Australia (DJ); Clinical Chemistry, South Australia Pathology, Adelaide, Australia (BECN); and the University of South Australia, Frome Road, Adelaide, Australia (JK and PC).

Background: It has been hypothesized that hip-fracture rates are higher in developed than in developing countries because high-protein (HP) Western diets induce metabolic acidosis and hypercalciuria. Confounders include interactions between dietary protein and calcium, sodium, and potassium.

Objective: We determined whether an HP or a high-normal-protein (HNP) weight-loss diet caused greater loss in bone mineral density (BMD) over 24 mo.

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