Functional and effective connectivity between reward and inhibitory control networks underlying subclinical binge eating.

Background: Knowledge is growing on the essential role of neural circuits involved in aberrant cognitive control and reward sensitivity for the onset and maintenance of binge eating.

Aims: To investigate how the brain's reward (bottom-up) and inhibition control (top-down) systems potentially and dynamically interact to contribute to subclinical binge eating.

Method: Functional magnetic resonance imaging data were acquired from 30 binge eaters and 29 controls while participants performed a food reward Go/NoGo task.

Non-linear interactions of lower limb clinical measures associated with asymptomatic Achilles tendon pathology in ballet dancers.

Context: Tendon abnormalities on imaging are commonly observed in individuals with Achilles tendinopathy. Those abnormalities can also be present in asymptomatic individuals, which is an important risk factor for developing tendon symptoms. Ballet dancers are particularly vulnerable due to the high loads placed on their Achilles tendons.

Global distribution and sustainable management of Asian corn borer (ACB), (Lepidoptera: Crambidae): recent advancement and future prospects.

The Asian corn borer (ACB), (Guenée, 1854), is a serious pest of several crops, particularly a destructive pest of maize and other cereals throughout most of Asia, including China, the Philippines, Indonesia, Malaysia, Thailand, Sri Lanka, India, Bangladesh, Japan, Korea, Vietnam, Laos, Myanmar, Afghanistan, Pakistan and Cambodia. It has long been known as a pest in South-east Asia and has invaded other parts of Asia, Solomon Islands, parts of Africa and certain regions of Australia and Russia. Consequently, worldwide efforts have been increased to ensure new control strategies for management.

Palovarotene in fibrodysplasia ossificans progressiva: review and perspective.

Introduction: Palovarotene is a retinoic acid receptor gamma agonist that was studied in phase-2 and phase-3 clinical trials for the inhibition of new heterotopic ossification (HO) in fibrodysplasia ossificans progressiva (FOP). Despite numerous setbacks and regulatory delays, palovarotene is now the first approved FOP treatment in the U.S.

Resonance, self-reflection, and preparedness through a web-based intervention for family caregivers of patients with life-threatening illness receiving specialised home care.

Objectives: In home-based care for severely ill patients, family caregivers' contributions are crucial. This study aimed to explore how a web-based psychoeducational intervention influences family caregivers' experiences in addressing challenges while caring for a patient with life-threatening illnesses during specialized home care.

Methods: This qualitative study undertook semi-structured interviews with family caregivers of patients with life-threatening illness receiving specialized home care.

Integrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms.

Thrombosis, a major cause of morbidity and mortality worldwide, presents a complex challenge in cardiovascular medicine due to the intricacy of clotting mechanisms in living organisms. Traditional research approaches, including clinical studies and animal models, often yield conflicting results due to the inability to control variables in these complex systems, highlighting the need for more precise investigative tools. This review explores the evolution of thrombosis models, from conventional polydimethylsiloxane (PDMS)-based microfluidic devices to advanced hydrogel-based systems and cutting-edge 3D bioprinted vascular constructs.

Synthesis and Investigation of Peptide-Drug Conjugates Comprising Camptothecin and a Human Protein-Derived Cell-Penetrating Peptide.

Drug targeting strategies, such as peptide-drug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs. Here we investigated the ability of PDCs comprising a human protein-derived cell-penetrating peptide-platelet factor 4-derived internalization peptide (PDIP)-as a targeting strategy to improve the selectivity of camptothecin (CPT), a topoisomerase I inhibitor that suffers from off-target toxicity. The intranuclear target of CPT allowed exploration of PDC design features required for optimal potency.

Return to On-Snow Performance in Ski Racing After Anterior Cruciate Ligament Reconstruction.

Background: The individual variation in on-snow performance outcomes after anterior cruciate ligament (ACL) reconstruction (ACLR) in elite alpine ski racers has not been reported and may be influenced by specific injury characteristics.

Purpose: To report the performance statistics of elite ski racers before and after ACLR and to identify surgical and athlete-specific factors that may be associated with performance recovery.

Study Design: Descriptive epidemiological study.

Association between 24-hour movement behaviors and adiposity in children and adolescents: A compositional data meta-analysis.

Purpose: To quantitatively synthesize published evidence on the association between 24-hour movement behavior composition with adiposity in children and adolescents aged 3-18 years.

Methods: Systematic literature searches were conducted in five electronic databases to identify papers published between January 2015 and January 2024. A machine learning-assisted systematic review was conducted to identify studies applying compositional data analysis to examine the association between 24-hour movement behaviors and adiposity in children and youth.

Reinvestigation into the role of lipopolysaccharide Glycosyltransferases in protein glycosylation.

Protein glycosylation has been considered as a fundamental phenomenon shared by all domains of life. In , glycosylation of flagellins A and B with pseudaminic acid have been rigorously confirmed and shown to be essential for flagella assembly and bacterial colonization. In addition to flagellins, several other proteins including RecA, AlpA/B, and BabA/B in have also been reported to be glycosylated and to be dependent on the lipopolysaccharide (LPS) biosynthetic pathway.

A scoping review of psychosocial interventions delivered by non-mental health workers following disaster events.

Individuals exposed to disasters are at high risk of developing mental health conditions, yet the availability of mental health practitioners is often limited. The aim of this scoping review was to examine the quality of the evidence for psychosocial interventions that can be delivered by non-mental health workers in the context of disasters. Searches were performed in PsycInfo, EMBASE, Family & Society Studies Worldwide, CINAHL, Global Health, PubMed, and SCOPUS, from inception through to November 2024, to identify studies of relevance.

Evaluation of EGFR-TKIs and ICIs treatment stratification in non-small cell lung cancer using an encrypted multidimensional radiomics approach.

Background: Radiomics holds great potential for the noninvasive evaluation of EGFR-TKIs and ICIs responses, but data privacy and model robustness challenges limit its current efficacy and safety. This study aims to develop and validate an encrypted multidimensional radiomics approach to enhance the stratification and analysis of therapeutic responses.

Materials And Methods: This multicenter study incorporated various data types from 506 NSCLC patients, which underwent preprocessing through anonymization methods and were securely encrypted using the AES-CBC algorithm.

Engaging health system, service and consumer representatives in the co-design of a multi-criteria decision-making framework for commissioning overweight and obesity programs and services.

Background: Obesity is a multi-faceted problem that requires complex health system responses. While no single program or service is sufficient to meet every individual's needs, some criteria that increase the likelihood of program/service quality delivery to produce effective outcomes exist. However, although research on health commissioning is available internationally and is growing within the Australian context, no evidence exists of a multi-criteria decision-making framework to address the complexity required for effective commissioning of overweight and obesity early intervention and weight management programs or services.

Health literacy and medication adherence in adults from ethnic minority backgrounds with Type 2 Diabetes Mellitus: a systematic review.

Background: For people living with Type 2 Diabetes Mellitus (T2DM), achieving optimal health outcomes requires optimal self-management and adherence to medical treatment. While some studies suggest an association between poor medication adherence and lower levels of health literacy, the evidence for this association remains inconclusive. This systematic review aimed to synthesise the evidence on the association between health literacy and medication adherence among adults from ethnic minority backgrounds living with T2DM.

Rehabilitation, reablement, and restorative care approaches in the aged care sector: a scoping review of systematic reviews.

Background: Ageing populations are set to drive up demand for aged care services, placing strain on economies funding social care systems. Rehabilitation, reablement, and restorative care approaches are essential to this demographic shift as they aim to support independent function and quality of life of older people. Understanding the impact of these approaches requires nuanced insights into their definitions, funding, and delivery within the aged care context.

Communicating certainty via verbal probability phrases: comparing health contexts with no context.

Introduction: Medical professionals often use verbal phrases to communicate uncertainties and certainties with their patients and the general public.

Objectives: This study aimed to investigate factors that can influence people's interpretation of probability phrases of certainty and uncertainty communicated by doctors in health and medical settings.

Methods: An experimental study with a randomized factorial design was conducted to examine both context-related factors and individual difference factors on participants' interpretation across directions of phrases and frames of the context.

Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2.

Background: Pancreatic cancer (PDAC: pancreatic ductal adenocarcinoma, the commonest form), a lethal disease, is best treated with surgical excision but is feasible in less than a fifth of patients. Around a third of patients presentlocally advanced, inoperable, non-metastatic (laPDAC), whose stadrd of care is palliative chemotherapy; a small minority are down-sized sufficiently to enable surgical excision. We propose a phase II clinical trial to test whether a combination of standard chemotherapy (gemcitabine & nab-Paclitaxel: GEM-NABP) and repurposing All Trans Retinoic Acid (ATRA) to target the stroma may extend progression-free survival and enable successful surgical resection for patients with laPDAC, since data from phase IB clinical trial demonstrate safety of GEM-NABP-ATRA combination to patients with advanced PDAC with potential therapeutic benefit.

Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data.

Background: Imaging-based spatial transcriptomics technologies allow us to explore spatial gene expression profiles at the cellular level. Cell type annotation of imaging-based spatial data is challenging due to the small gene panel, but it is a crucial step for downstream analyses. Many good reference-based cell type annotation tools have been developed for single-cell RNA sequencing and sequencing-based spatial transcriptomics data.

Electrostatic and Electronic Effects on Doped Nickel Oxide Nanofilms for Water Oxidation.

An ideal water-splitting electrocatalyst is inexpensive, abundant, highly active, stable, selective, and durable. The anodic oxygen evolution reaction (OER) is the main bottleneck for H production with a complex and not fully resolved mechanism, slow kinetics, and high overpotential. Nickel oxide-based catalysts (NiO) are highly active and cheaper than precious metal catalysts.

Auditing Cause of Death Reporting to Australia and New Zealand's Dialysis and Transplant Registry: A Retrospective Cohort Study.

Aim: National data registries provide a valuable source of data for epidemiological research but may be subject to inaccuracies. Whilst studies have compared agreement between cause of death (COD) data from Australia and New Zealand's dialysis and transplant registry (ANZDATA) to other databases, no studies have manually compared agreement with electronic medical records (EMR). This study aimed to assess the agreement between COD for dialysis patients in the Western Sydney renal service according to ANZDATA and EMR.