La dolce vita: fueling chimeric antigen receptor (CAR) T cells with Glut1 to improve therapeutic efficacy.

The approval of chimeric antigen receptor (CAR) T cell therapies for the treatment of hematological cancers has marked a new era in cancer care, with seven products being FDA approved since 2017. However, challenges remain, and while profound effects are observed initially in myeloma, the majority of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immune evasion mechanisms, and poor infiltration and persistence.

A psychometric evaluation of the Indonesian version of the collaborative practice assessment tool (CPAT) for assessing interprofessional education and collaborative practice among health practitioners and students.

Research focus has transitioned from interprofessional collaborative practice among qualified health practitioners to the involvement of pre-qualifying students in practicing interprofessional education. It is essential to establish outcome measures to enhance the seamless integration of interprofessional education and collaborative practice. The aim of this study was to develop a culturally appropriate quality measure for assessing interprofessional education and collaborative practice for health practitioners and students in Indonesia by performing cross-cultural validation of the collaborative practice assessment tool (CPAT).

Cancer metastasis to the upper gastrointestinal tract-a case series.

Background: Metastasis of non-gastrointestinal (non-GI) cancers to the upper GI tract is a rare occurrence, with limited cases reported in the literature. Recognising this type of metastasis is crucial, as it presents unique diagnostic and therapeutic challenges. This case series adds to the literature by discussing seven rare cases of non-GI cancer metastasising to the upper GI tract, emphasising the complications and clinical manifestations.

Evidence-Based Teaching Strategies for Assessing Pressure Injuries in Older Nursing Home Residents With Darker Skin Tones.

Aim: To describe the development and implementation of evidence-based teaching strategies for assessing and classifying pressure injuries in older nursing home individuals ≥ 60 years old with darker skin tones.

Design: Pressure injury assessment learning interventions based on pre- and post-test assessments.

Methods: The learning interventions were developed by experts in pressure injury education and were based on empirical evidence, international clinical practice guidelines, and underpinned by social constructivism theory and the integrated interactive teaching model.

Strategic tips to successfully undertake research: a comprehensive roadmap for medical trainees.

Engaging in research during medical training is crucial for fostering critical thinking, enhancing clinical skills, and deepening understanding of medical science. Despite its importance, the shortage of physician-scientists lingers with many trainees and junior doctors encountering challenges navigating the research process. Drawing on current literature, this article provides a comprehensive roadmap, categorising 12 actionable strategies into five themes, to help medical trainees overcome common obstacles and optimise their research experience.

Boron controls apical dominance in Pea (Pisum sativum) via promoting polar auxin transport.

Plant architecture and subsequent productivity are determined by the shoot apical dominance, which is disturbed by the deficiency of boron, one of the essential trace elements for plant growth and reproduction. However, the mechanism by which B controls shoot apical dominance or axillary bud outgrows under B deficiency is still unclear. This work aimed to investigate the mechanistic basis of this process, with focus on the interaction between B and polar auxin transport.

Networks of support: Microboards for children with intellectual disability.

Friendships are an important aspect of social inclusion and can have a positive influence on a child's social and emotional wellbeing beyond childhood. A Microboard is a formal approach to building supportive relationships for people with intellectual disability. Establishing a Microboard during childhood may facilitate a peer support network that endures into adulthood.

Siblings of adults with intellectual disabilities in Chinese societies: A scoping review.

Adult siblings without disabilities play important roles in relation to their brothers and sisters with intellectual disabilities. This study reviewed knowledge about adult sibling relationships in Chinese societies, where one sibling has intellectual disability. Five English and two Chinese databases were searched for publications published up to 2022.

Supporting healthy ageing for people with intellectual disabilities in group homes: Staff experiences.

Background: This study explores the perceptions of supported accommodation staff and their managers of the support needs of residents ageing with intellectual disabilities, and their experiences of adjusting services for this group in the context of individualised funding.

Method: Qualitative interviews were conducted with 21 staff working in Australian supported accommodation services.

Findings: Four themes emerged.

The relationship of productivity-based wages to human rights and occupational justice - an exploratory study.

Background: Productivity-based wage systems are intended to enhance the labour market participation of people with disabilities. Limited scholarship exists regarding the impact of such policies in practice. This qualitative study explored stakeholder perspectives on the Australian Supported Wage System (SWS), including perceptions of fairness and equity.

Clinical supervision in positive behaviour support: A brief report on the perspectives of practitioners in Australia.

Purpose: To examine current practices and recommendations regarding clinical supervision from the perspective of Positive Behaviour Support (PBS) practitioners in Australia.

Methods: A qualitative study design consisting of semi-structured interviews with 14 PBS practitioners.

Results: Positive supervision experiences revealed the importance of "a supportive relationship", "supporting reflective practice", and "different supervisors fulfilling different needs.

Inclusive mainstream services for people with intellectual disabilities: A relational approach.

Background: Despite growing recognition of their right for inclusion in society, people with intellectual disabilities are often excluded from mainstream services, or experience poor service outcomes.

Method: Taking a relational approach that considers the interpersonal relations and interactions that occur in mainstream service settings in Australia, this paper examines the features of services that research participants considered more inclusive.

Results: Relations between service users with and without intellectual disabilities, mainstream service staff and disability support workers in inclusive mainstream services were characterised by; respect; warm, welcoming and convivial interpersonal engagement; active listening; proactive assistance; flexibility; mediation to create a safe environment; and collaboration and shared responsibility by both mainstream staff and disability support workers in supporting a service user with intellectual disability.

Work stress and professional quality of life in disability support workers: The mediating role of psychological flexibility.

Background: This study aimed to explore perceived work stress and its association with burnout, compassion fatigue, and compassion satisfaction and the mediating effect of psychological flexibility on these relationships.

Method: Two hundred and fifty-one disability support workers across Australia reported on work stress, psychological flexibility, burnout, compassion fatigue, and compassion satisfaction through an online anonymous survey.

Results: Perceived work stress was found to have a significant relationship with burnout, compassion fatigue, and compassion satisfaction.

Preconditions influencing the development of post-secondary training programs in universities for individuals with intellectual disabilities.

Background: Research on post-secondary training for individuals with intellectual disabilities has generally focused on programs, with little consideration of the structures and mechanisms that give rise to them. This article adopts a critical realist perspective to comparatively analyse and theorise about the contextual structures contributing to the introduction of post-secondary training programs in universities for individuals with intellectual disabilities.

Method: Six stages in critical realist explanatory research were followed.

A comparative analysis of the prevalence and predictors of chronic pain in older adults with and without intellectual disability in Australia.

Background: There is little research comparatively assessing prevalence of pain between older people either with or without intellectual disability. This paper explores health and social factors associated with chronic pain in these two groups.

Method: A cross-sectional survey was undertaken in New South Wales and Queensland, Australia.

Down syndrome or Rett syndrome in the family: Parental reflections on sibling experience.

Background: Siblings of children with intellectual disability have unique family experiences, varying by type of disability.

Methods: Parents of children with Down syndrome (156) or with Rett syndrome (149) completed questionnaires relating to sibling advantages and disadvantages, experiences of holidays and recreation, and perceived availability of parental time. Qualitative responses were analysed using thematic analysis.

Characteristics of children attending an autism specific early learning and care setting prior to and following introduction of the National Disability Insurance Scheme.

Background: The rollout of the National Disability Insurance Scheme (NDIS) has transformed the Australian funding landscape for individuals with disability and their families. This study examined whether the profiles of autistic children and their families accessing an early intervention (EI) setting have changed following its introduction.

Methods: The cognition and behavioural profiles of children funded under the NDIS ( = 58) were compared to children who had received block government funding (= 58).

The Back to Back Theatre film internship program for people with intellectual disability: A summative evaluation.

Background: Internships may be a successful pathway for increasing employment rates among people with intellectual disability. This paper presents a summative evaluation of a brief film internship program for people with intellectual disability.

Method: At the commencement and conclusion of the internship, semi-structured interviews were conducted with eight interns and 10 mentors.

The adaptation experience of families with children with developmental disabilities in Mainland China.

Background: Families of children with developmental disabilities face extraordinary changes in their life circumstances and needs that require adaptations to create sustainable and meaningful daily routines. The present study explored the adaptation of Chinese families of children with developmental disabilities from an ecocultural theoretical perspective.

Method: A total of 34 families of children with developmental disabilities were interviewed using the adapted Family Life Interview, and the data were analysed thematically.

The juncture and disjuncture of service delivery systems in post-parental care planning for rural people with intellectual disabilities.

Background: Australian research indicates that post-parental care transitions are rarely planned and primarily occur following a crisis for a primary carer. This paper examines disability staff perceptions of transitions for people with intellectual disability and their ageing carers in rural South Australia.

Method: A focus group interview model was used, with a semi-structured interview guide initiating group discussions.

Return to preinjury pivoting sports after anterior cruciate ligament reconstruction is different between males and females, as are the patient-reported reasons.

Purpose: To investigate return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR), differences based on sex and concomitant meniscal repair, and identify reasons why patients do not RTS.

Methods: Overall, 232 patients undergoing ACLR, with or without concomitant meniscal repair, that were actively participating in pivoting sports at the time of injury, were prospectively recruited. At 2 years, return to preinjury pivoting sport was investigated and, if they had returned, whether they felt their performance was at (or better) or below preinjury status.

What is ethically required to adapt to intellectual disability in cancer care? A case study of testicular cancer management.

Background: People with intellectual disability who require cancer services face several barriers and inequities, including delayed or unrecognised cancer diagnosis and inadequate attention paid to their specific concerns, needs and preferences about care.

Methods: In this case report, we present a case report of a 33-year-old male with severe intellectual disability requiring treatment for metastatic testicular cancer. The patient's intellectual disability required major adjustments to the delivery of chemotherapy.

Educating the educated: The impact of educational interventions on knowledge, attitudes and confidence of healthcare professionals in caring for patients with intellectual disability: A systematic review.

Background: The attitudes, perceptions and inherent biases of healthcare professionals (HCPs) have the potential to influence and inform health outcomes of people with intellectual disability. This review aimed to identify what educational interventions have been conducted to improve the attitude, knowledge, and confidence of HCPs in caring for people with intellectual disability.

Method: A systematic literature review was conducted using Medline, ERIC and PsycINFO.

Whose voice is it anyway? Adults with intellectual disabilities and future planning: A scoping review of qualitative studies.

Background: Future planning is a way of supporting people with intellectual disabilities and their families to think about their support needs as both groups age. Adults with intellectual disabilities, family members, and service providers are often involved in planning processes. However, it is unclear whose perspectives dominate in the literature and how these might vary.