Availability and Key Characteristics of National Early Warning Systems for Emerging Profiles of Antimicrobial Resistance in High-Income Countries: Systematic Review.

Background: The World Health Organization (WHO) recently advocated an urgent need for implementing national surveillance systems for the timely detection and reporting of emerging antimicrobial resistance (AMR). However, public information on the existing national early warning systems (EWSs) is often incomplete, and a comprehensive overview on this topic is currently lacking.

Objective: This review aimed to map the availability of EWSs for emerging AMR in high-income countries and describe their main characteristics.

Migrant parents' perceptions of the benefits, barriers, and facilitators of young children's physical activity and sedentary behavior: A systematic review of qualitative studies.

Introduction: Despite increasing global migration, children from migrant backgrounds are underrepresented in physical activity research. This systematic review aimed to consolidate existing qualitative evidence on parental perceptions of the benefits, barriers, and facilitators of promoting physical activity and limiting sedentary behavior of their first- or second-generation migrant children aged 0-6 years.

Methods: Six electronic databases (Medline, CINAHL, PsycINFO, SPORTDiscus, Global, and Health EMBASE) were searched for qualitative peer-reviewed English language studies using terms covering migrants, parents, perceptions, physical activity, and sedentary behavior.

Internalized Transnegativity, Self-Warmth, Self-Coldness, and Eating Disorder Symptomatology Among Transgender and Nonbinary Adults.

Eating disorders (EDs) are highly prevalent among transgender and nonbinary (TNB) adults, and internalized transnegativity is a key risk factor for ED symptomatology. Although extant literature has established that self-compassion protects against EDs among the cisgender population, research among TNB adults is nascent. The current study sought to identify whether internalized transnegativity and components of self-compassion (i.

Impact of Heat and Mitigation Strategies on Healthcare Professionals: A Scoping Review.

Background: Rising global temperatures and increased use of personal protective equipment has led to increased risk of heat stress amongst healthcare professionals. This review synthesizes recent research on the impact of heat and heat mitigation strategies on healthcare professionals across disciplines and settings.

Method: Databases were systematically searched using keywords and data from included studies were extracted for content analysis.

Recognising vicarious trauma in research: the experiences of researchers who work with victimisation data and the support they need.

Background: The vicarious trauma people who provide direct clinical care may experience is well documented. However, there is limited information about the vicarious trauma that researchers working with victim-survivors of domestic and family violence (DFV) or victimisation-related data may experience.

Aim: To describe and reflect on the vicarious trauma experienced by people researching DFV who have repeatedly been exposed to significant, traumatic data.

Physician knowledge, use, and perceptions of genetic biomarker testing for the management of patients with newly diagnosed advanced ovarian cancer: an international physician survey.

Aims: To explore physician-reported knowledge, use, and perceptions of genetic testing for advanced ovarian cancer management.

Materials & Methods: Gynecology/oncology specialists ( = 390) in the US, Europe, Canada, Japan, and Australia completed an online survey spanning March 2021 to April 2022.

Results: Physician-reported breast cancer gene mutation (BRCAm) testing rates increased over the 2 years before the survey; most patients underwent testing in the preceding 6 months.

A Drug-Drug Interaction Study of Mobocertinib and Midazolam, a Cytochrome P450 3A Substrate, in Patients With Advanced Non-Small Cell Lung Cancer.

Mobocertinib is a kinase inhibitor designed to selectively target epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations in non-small cell lung cancer. This drug-drug interaction study assessed the effect of multiple-dose administration of mobocertinib on the pharmacokinetics (PK) of midazolam, a sensitive cytochrome P450 3A substrate. Patients with locally advanced or metastatic non-small cell lung cancer refractory/intolerant to standard available therapy were enrolled.

Perceptions and Use of Extended-Duration Exposure Therapy Amongst Psychologists.

Background: Extended-duration exposure therapy, in which treatment is delivered over a single prolonged session or cluster of long-duration sessions, is a highly efficacious and efficient treatment for anxiety disorders such as specific phobias. Despite this, little is known about the use of extended-duration exposure therapy in clinical practice.

Methods: In the present study we investigated the perceptions and use of extended-duration exposure therapy amongst a sample of Australian psychologists via a survey, and the Therapist Beliefs about Exposure Scale.

Food Allergy and Mental Health in Children and Adolescents-The Role of Shared Familial Environment.

Background: Evidence suggests a link between food allergy and poor mental health, however, this may be explained by shared genetic and environmental factors. We aimed to investigate the association between food allergy of different severity and mental health in children, and the role of familial factors.

Methods: This population-based, longitudinal cohort study is based on the Child and Adolescent Twin Study in Sweden with questionnaire data reported by parents and/or children.

Sitosterolemia-An Underdiagnosed and Heterogeneous Lipid Disorder. A Case Series From a Tertiary Care Centre in Australia.

Aims: Sitosterolemia, is a disorder of increased plant sterol levels leading to a variable presentation and haematological manifestations. Although considered rare, the prevalence is likely underestimated due to the variable phenotype and challenges in diagnosis. The delayed diagnosis may lead to cardiovascular complications.

Negative interpretation bias and repetitive negative thinking as mechanisms in the association between insomnia and depression in young adults.

Objectives: Despite evidence supporting sleep's role in the development and maintenance of depression, mechanisms underlying this association in young people are less established. Negative interpretation bias (the tendency to interpret ambiguous situations negatively) and repetitive negative thinking (RNT) are important candidate mechanisms. Whilst negative interpretation bias is implicated in depression development, it is a transdiagnostic process and may result from insomnia.

Advances in Oxygen Evolution Reaction Electrocatalysts via Direct Oxygen-Oxygen Radical Coupling Pathway.

Oxygen evolution reaction (OER) is a cornerstone of various electrochemical energy conversion and storage systems, including water splitting, CO/N reduction, reversible fuel cells, and rechargeable metal-air batteries. OER typically proceeds through three primary mechanisms: adsorbate evolution mechanism (AEM), lattice oxygen oxidation mechanism (LOM), and oxide path mechanism (OPM). Unlike AEM and LOM, the OPM proceeds via direct oxygen-oxygen radical coupling that can bypass linear scaling relationships of reaction intermediates in AEM and avoid catalyst structural collapse in LOM, thereby enabling enhanced catalytic activity and stability.

Assessment of healthcare facilities' readiness to provide antenatal care in Ethiopia: facility based study using service provision assessment data.

Background: Readiness of healthcare facilities is essential for delivering quality healthcare services. There is limited evidence on the antenatal care (ANC) readiness of healthcare facilities in Ethiopia. This study aimed to assess the readiness of ANC services and its influencing factors in Ethiopian healthcare facilities.

Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China.

Background: Hemorrhagic fever with renal syndrome (HFRS) is a climate-sensitive zoonotic disease that poses a significant public health burden worldwide. While previous studies have established associations between meteorological factors and HFRS incidence, there remains a critical knowledge gap regarding the heterogeneity of these effects across diverse epidemic regions. Addressing this gap is essential for developing region-specific prevention and control strategies.

Feasibility of home-based urine collection in children under 5 years in the ORIGINS birth cohort study: mixed method protocol and sample completion results.

Background: Urine is an attractive biospecimen for nutritional status and population health surveys. It is an excellent non-invasive alternative to blood for appropriate biomarkers in young children and is suitable for home-based collection, enabling representative collections across a population. However, the bulk of literature in this population is restricted to collection in primary care settings.

Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression.

Background: Inclusion Body Myositis is an acquired muscle disease. Its pathogenesis is unclear due to the co-existence of inflammation, muscle degeneration and mitochondrial dysfunction. We aimed to provide a more advanced understanding of the disease by combining multi-omics analysis with prior knowledge.

A rare haplotype of the GJD3 gene segregating in familial Meniere's disease interferes with connexin assembly.

Background: Familial Meniere's disease (FMD) is a rare polygenic disorder of the inner ear. Mutations in the connexin gene family, which encodes gap junction proteins, can also cause hearing loss, but their role in FMD is largely unknown.

Methods: We retrieved exome sequencing data from 94 individuals in 70 Meniere's disease (MD) families.

Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus.

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood glucose levels, thereby minimizing diabetes-related complications. However, given the injectable nature of exogenous insulin, apprehensions regarding its safety and the difficulties associated with its administration have hindered its widespread and prompt utilization.

Opioid-related harms and experiences of care among people in justice settings in New South Wales, Australia: evidence from the National Ambulance Surveillance System.

Background: People in justice settings experience higher rates of psychiatric morbidity, including alcohol and drug use disorders, compared with the general population. However, our understanding of opioid-related harms in justice settings is limited. This study used ambulance data to examine opioid-related harms and experiences of care in New South Wales (NSW), Australia, during periods of incarceration or detention.

Cost-utility and cost-benefit analysis of a multi-component intervention (NEXpro) for neck-related symptoms in Swiss office workers.

Background: Neck pain is a significant public health issue, especially among office workers, with a prevalence ranging from 42 to 68%. This study aimed to evaluate the cost-utility and cost-benefit of a multi-component intervention targeting neck pain in the general population of office workers in Switzerland. The 12-week multi-component intervention consisted of neck exercises, health promotion information workshops, and workplace ergonomics sessions.