Altered KEGG pathways are associated with different immunologic responses to antiretroviral therapy in HIV-infected men who have sex with men.

Background: The association between Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways and immunologic non-response among people living with HIV (PLHIV) on antiretroviral therapy (ART) is not well documented. This study aimed to characterize KEGG metabolic pathways among HIV-infected men who have sex with men (MSM) with different immunologic responses.

Methods: We recruited HIV-uninfected MSM (healthy controls, HC) and HIV-infected MSM on ART > 24 months in Guangzhou, June-October 2021.

Knowledge and practices of regional and rural general practitioners in the identification and management of intimate partner and family violence: a mixed methods study in Western Australia.

Background: General Practitioners (GPs) are well placed to identify and assist patients experiencing intimate partner violence (IPV) and family violence (FV). However, patients experiencing IPV/FV can be under-detected or inadequately assisted when GPs do not have the necessary confidence, knowledge, attitudes or skills for this. Given the high rates of IPV/FV in the Australian regional setting where this study was conducted, this investigation explored the confidence, knowledge, attitudes and practices of local GPs in identifying and managing patients who are experiencing IPV/FV.

Transcriptional profiles reveal physiological mechanisms for compensation during a simulated marine heatwave in Yellowtail Kingfish (Seriola lalandi).

Background: Changing ocean temperatures are already causing declines in populations of marine organisms. Predicting the capacity of organisms to adjust to the pressures posed by climate change is a topic of much current research effort, particularly for species we farm or harvest. To explore one measure of phenotypic plasticity, the physiological compensations in response to heat stress as might be experienced in a marine heatwave, we exposed Yellowtail Kingfish (Seriola lalandi) to sublethal heat stress, and used the transcriptome in gill and muscle, benchmarked against heat shock proteins and oxidative stress indicators, to characterise the acute heat stress response (6 h after the initiation of stress), and the physiological compensation to that response (24 and 72 h after the initiation of stress).

Differential gene expression and metabolic pathways in Toona sinensis: Influence on colour and aroma.

Toona sinensis, a plant species renowned for its culinary and medicinal properties, exhibits diverse colour variations that contribute to its aesthetic appeal and commercial value. Understanding the molecular mechanisms underlying colour and aroma traits in Toona sinensis is crucial for breeding programs and quality regulation in agriculture and the food industry. The present investigation included a comprehensive analysis of the transcriptomic and metabolomic profiles of Toona sinensis with different colours, including green, red, and red leaves with green stems.

The environmental impact of multi-specialty robotic-assisted surgery: a waste audit analysis.

Modern advances in medicine and technology have led to an increase in robotic-assisted surgery (RAS) cases. However, concerns have been raised about the potential environmental impact of RAS. Despite this, only limited quantitative evidence is currently available.

Characterization and machine learning analysis of hybrid alumina-copper oxide nanoparticles in therminol 55 for medium temperature heat transfer fluid.

Efficient heat dissipation is crucial for various industrial and technological applications, ensuring system reliability and performance. Advanced thermal management systems rely on materials with superior thermal conductivity and stability for effective heat transfer. This study investigates the thermal conductivity, viscosity, and stability of hybrid AlO-CuO nanoparticles dispersed in Therminol 55, a medium-temperature heat transfer fluid.

Urine electrooxidation for energy-saving hydrogen generation.

Urea electrooxidation offers a cost-effective alternative to water oxidation for energy-saving hydrogen production. However, its practical application is limited by expensive urea reactants and sluggish reaction kinetics. Here, we present an efficient urine electrolysis system for hydrogen production, using cost-free urine as feedstock.

'I'm glad my baby has weaned so I don't need to make that decision.' Understanding breastfeeding-related COVID-19 vaccine narratives on social media.

Issue Addressed: During the coronavirus disease 2019 (COVID-19) pandemic, the infodemic has been highly visible. Vaccine-related advice and evidence-based guidelines for breastfeeding women have lagged, and, at times have been contradictory and confusing. Breastfeeding is an important public health issue with long-lasting health benefits for infants and mothers.

ROSAH syndrome presenting with recurrent vitreous hemorrhage: a multimodal imaging study.

Background: ROSAH syndrome is an autosomal dominant systemic disease featuring etinal dystrophy, ptic nerve edema, plenomegaly, nhidrosis and migrainous eadache. Ocular manifestation of ROSAH syndrome can simulate posterior uveitis, vasculitis, generalized retinal dystrophy and neuroretinitis.

Purpose: To report a case of a 17-year-old female presenting with recurrent vitreous hemorrhage on a background of dental anomalies and anhidrosis.

Plasma glows and shifting water flows: Measuring the changes to water transport phenomena in seeds after plasma treatment.

Plasma discharges have been used as a treatment for seeds for a variety of food, horticultural and agricultural applications. It has generally been reported that plasma exposure increases the seed's water wettability, with some studies reporting increased water imbibition by seeds. It is speculated that increased water imbibition after plasma treatment is related to increased germination especially for food crops, yet there is little mechanistic understanding of why this may be so.

French validation of the Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) with determination of cutoff scores: A valuable tool in clinical practice.

Work difficulties are a primary issue of multiple sclerosis (MS). This is because disease onset usually occurs during a time when establishing a career and employment is of paramount importance. The MSWDQ-23 (Multiple Sclerosis Work Difficulties Questionnaire) was developed to assess work difficulties in MS.

Nurses' Readiness to Implement the Critical-Care Pain Observation Tool in the Intensive Care Unit-Instrument Adaptation and Psychometric Analysis.

Background: Ensuring effective pain assessment and management in intensive care units (ICUs) is crucial for promoting the well-being of patients.

Purpose: To develop and investigate the psychometric properties of an instrument designed to measure nurses' readiness for implementing the Critical-Care Pain Observation Tool in ICUs in Saudi Arabia.

Design: This study involved instrument adaptation and psychometric testing.

A general TD-Q learning control approach for discrete-time Markov jump systems.

This paper develops a novel temporal difference Q (TD-Q) learning approach, designed to address the robust control challenge in discrete-time Markov jump systems (MJSs) which are characterized by entirely unknown dynamics and transition probabilities (TPs). The model-free TD-Q learning method is uniquely comprehensive, including two special cases: Q learning for MJSs with unknown dynamics, and TD learning for MJSs with undetermined TPs. We propose an innovative ternary policy iteration framework, which iteratively refines the control policies through a dynamic loop of alternating updates.

So far away: threshold copying distances for multiple-choice answers in different exam room settings.

Clinical Relevance: Paper-based multiple-choice exams are commonly used to assess students. Answer sheets for these exams have a configuration which affords a potential opportunity for cheating.

Background: A proportion of students report cheating on assessments.

Impact of the Play Active policy intervention on early childhood educator's sedentary behaviour-related practices, psychosocial influences and meeting policy recommendations: Results from a pragmatic cluster randomized trial.

Background: High levels of sedentary behaviour are associated with poor child health outcomes such as obesity. Early childhood education and care (ECEC) services are a key intervention setting. Most ECEC policy-based interventions focus on children's nutrition and physical activity with few aimed at children's sedentary behaviour.

Remote health solutions in Far East Gippsland: a mixed-methods, co-designed evaluation of health service availability in isolated communities.

Introduction: Australians living in isolated communities are more likely to experience poorer health outcomes as a result of rurality. This article provides a needs assessment of healthcare services in a geographically isolated region of Victoria, Australia.

Methods: The research project employed a mixed-methods design.

Using trauma-informed approaches: research with climate disaster affected communities.

Climate disasters like floods and bushfires have increased in frequency and intensity in Australia. For many, these disasters are associated with trauma. In order to further our understanding of the impacts of these disasters on individuals and communities, we need to conduct research, but the research design and implementation need to be sensitive to that trauma and support the safety of both participants and researchers.

Quality Indicators for Non-Small Cell Lung Cancer in Queensland, Australia, 2012-2021.

Background: Quality indicators for non-small cell lung cancer (NSCLC) have been implemented in Queensland, Australia, to assess performance across 28 elements relating to diagnosis, access, treatment, and outcomes.

Methods: Linked data were sourced from the population-based Queensland Oncology Repository. Eligible people were diagnosed with NSCLC between 2012 and 2021, with follow-up on treatment and mortality available to 31 December 2022.

The Future of Arthroplasty in the Spine.

The evolution of spinal arthroplasty, a significant journey that began in the 1960s and 1970s, has seen remarkable progress. Initially designed to preserve motion at spinal segments and avoid complications associated with fusion surgeries, early designs faced setbacks due to rudimentary concepts and limited materials. However, the 1980s marked a turning point with the development of modern total disc replacement concepts, utilizing advanced materials such as titanium and polyethylene to improve implant longevity and integration.