Longitudinal Trajectories of Dental Attendance in Australian Adults.

Understanding how dental attendance evolves throughout life can inform targeted preventive health care policies by identifying key moments when people are more or less likely to seek dental care. Trajectory modeling of age and time trajectories takes a life course approach to understanding dental attendance, offering insights into both developmental perspectives (e.g.

Patterns and Duration of Antidepressant Use in Australian Women: Findings From the Australian Longitudinal Study on Women's Health.

Antidepressant use is common in women. However, characteristics associated with duration of use remain unclear. We conducted a descriptive study using data from the 1973-1978 and 1946-1951 birth cohorts of the Australian Longitudinal Study on Women's Health linked to antidepressant dispensing records from the Pharmaceutical Benefits Scheme, July 2012 to December 2019 to examine use patterns and their associated characteristics.

Exploring clinician perspectives on the DSM-5 eating disorder severity ratings: a qualitative study.

The DSM-5 introduced severity ratings in 2013 for anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED) based on BMI, compensatory behaviour frequency, and binge eating frequency, respectively. While several studies have assessed the validity of these ratings, little is known about their use in clinical practice. This study examined clinicians' use of DSM-5 severity ratings and their views on their clinical value.

CRISPR/Cas9 Mediated Editing of Bdtektin1 Gene Induces Sterility in Male Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae).

The Oriental fruit fly, Bactrocera dorsalis (B. dorsalis) is a highly invasive, widely distributed notorious pest restricting global fruit trade immensely. There are several approaches to managing this pest, still require newer approaches.

Diagnostic Integrity of DSM Categorized Eating Disorders: Exploration of Alternative Methods of Classification and the Implications for Genetic Research.

Research is only beginning to shape our understanding of eating disorders as metabolic-psychiatric illnesses. How eating disorders (EDs) are classified is essential to future research for understanding the etiology of these severe illnesses and both developing and tailoring effective treatments. The gold standard for classification for research and diagnostic purposes has primarily been and continues to be the (DSM-5).

Evolutionary implications of a deep-time perspective on insect pollination.

Plant pollination by insects represents one of the most transformative and iconic ecological relationships in the natural world. Despite tens of thousands of papers, as well as numerous books, on pollination biology published over the past 200 years, most studies focused on the fossil record of pollinating insects have only been published in the last few decades, and this field is still undergoing major developments. Current palaeontological evidence indicates that pollinating insects were diverse and participated in the reproduction of different gymnosperm lineages long before their association with flowering plants (angiosperms).

Maternal perinatal depression and the risk of disruptive behavioural disorder symptoms among offspring: A systematic review and meta-analysis.

Inconsistent findings exist regarding the association between maternal perinatal depression and the risk of Disruptive Behavioural Disorder (DBD) symptoms, including Conduct Disorder (CD) and Oppositional Defiant Disorder (ODD) symptoms in children and adolescents. This study aimed to estimate the overall risk of DBD symptoms in offspring of mothers who have experienced perinatal depression. PubMed, Medline, Embase, Scopus, CINAHL, and Psych INFO were searched.

Thymoma-Induced Severe Biventricular Failure without Myasthenia Gravis: Investigating Tachycardia-Induced Cardiomyopathy.

BACKGROUND Cardiomyopathy associated with thymoma is thought to be a cardiac manifestations of myasthenia gravis (MG). However, there are case reports of newly diagnosed thymoma presenting with cardiomyopathy without MG, and the mechanism remains unclear. The purpose of this report is to explore tachycardia-induced cardiomyopathy (TIC) as a potential mechanism for cardiomyopathy in thymoma without features of MG.

Co-design of a single session intervention chatbot for people on waitlists for eating disorder treatment: a qualitative interview and workshop study.

Background: Early treatment is critical to improve eating disorder prognosis. Single session interventions have been proposed as a strategy to provide short term support to people on waitlists for eating disorder treatment, however, it is not always possible to access this early intervention. Conversational artificial intelligence agents or "chatbots" reflect a unique opportunity to attempt to fill this gap in service provision.

Clinical staff's perceptions of transitional care from hospital to home for stroke patients: a qualitative study.

Background: The transition from hospital to home is a critical period for stroke survivors and their caregivers. This study explores the clinical staff's attitudes and perspectives on transitional care (from hospital to home) for stroke patients in the neurology department.

Methods: This qualitative descriptive phenomenological study involved semi-structured interviews with 15 clinical staff members in the neurology department of a tertiary hospital, conducted either face-to-face or via telephone.

Public perception of chiropractic in the Taiwanese population: a cross-sectional survey.

Background: Research on perception of chiropractic is abundant in Western contexts, yet sparse in Asia. This study aims to bridge this gap by examining the perceptions of chiropractic among Taiwanese adults, focusing on demographics, utilisation, beliefs, and understanding.

Methods: An adapted survey with 27 close-ended items was administered to assess Taiwanese adults' perception of chiropractic.

The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation.

Background: Endothelial dysfunction is a hallmark feature of cardiovascular disease (CVD), yet the underlying mechanisms are still poorly understood. This has impeded the development of effective therapies, particularly for peripheral artery disease. FK506-binding protein like (FKBPL) and its therapeutic peptide mimetic, AD-01, are crucial negative regulators of angiogenesis, however their roles in CVD are unknown.

Health service utilisation cost associated with residential fire incidents in New South Wales, Australia.

Background: Fire is a major contributor to global fatalities and disabilities and remains a prevalent threat to individuals in Australia. New South Wales (NSW) experiences over one-third of all structure fires, including residential ones, in the country and one-quarter of all associated deaths and hospital admissions. In an atmosphere of rising healthcare cost and heightened demand for its services, obtaining total cost data for residential fires is essential.

"Like a rollercoaster": carer experiences of residential treatment for eating disorders.

Background: Residential facilities for eating disorders are becoming increasingly common, providing recovery-oriented care in less restrictive environments compared to traditional hospital treatments. Despite their popularity, there is a lack of research regarding parent and carer experiences of residential programs. Furthermore, while the impact of eating disorders on parents and caregivers is well-documented, understandings of their lived experiences remain limited.

Health behaviour interventions to improve mental health outcomes for students in the university setting: a systematic review of randomised controlled trials.

Background: University students incur significantly elevated levels of stress compared to the general population and their non-student counterparts. Health risk behaviours are important modifiable determinants for the onset and aggravation of various mental health disorders, in which, university students generally exhibit poor engagement. Thus, this study aims to determine the efficacy of health behaviour interventions in relation to change in health behaviour and mental health outcomes, the impact of interventions (i.

Assessing the impact of a mandatory calorie labelling policy in out-of-home food outlets in England on consumer behaviour: a natural experimental study.

Background: Out-of-home (OOH) food tends to be energy-dense and nutrient-poor. In response, England implemented a mandatory calorie labelling policy in the OOH sector. We evaluated changes in consumer behaviours after the policy was implemented in April 2022.

Behavioural and psychological factors associated with pre-frailty in community-dwelling adults aged 40 and over: a cross-sectional study.

Frailty and pre-frailty are major public health concerns. While frailty is typically associated with older adults, evidence suggests that pre-frailty commonly starts in middle-age. This study examined associations between behavioural and psychological correlates of pre-frailty and frailty in adults from 40 years to help identify at-risk individuals and inform interventions.

International evidence-based recommendations for polycystic ovary syndrome in adolescents.

Background: During adolescence, accurate diagnostic criteria and/or identification of adolescents "at risk" of polycystic ovary syndrome (PCOS) are critical to establish appropriate screening, treatment, and lifelong health plans. The 2023 International Evidence-Based Guideline for PCOS aimed to provide the most up-to-date evidence-based recommendations to improve health outcomes for individuals with PCOS, emphasizing accurate and timely diagnosis of PCOS from adolescence.

Methods: The best practice methods following the Appraisal of Guidelines for Research and Evaluation (AGREE-II) criteria were applied.

Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile.

Background: The ataxia-telangiectasia mutated (ATM) kinase phosphorylates and activates several downstream targets that are essential for DNA damage repair, cell cycle inhibition and apoptosis. Germline biallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), and heterozygous pathogenic variant (PV) carriers are at increased risk of cancer, notably breast cancer. This study aimed to investigate whether DNA methylation profiling can be useful as a biomarker to identify tumors arising in ATM PV carriers, which may help for the management and optimal tailoring of therapies of these patients.

Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.

Objective: Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection.

Results: Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included.

Use of evidence to inform regional primary health care planning in Australia.

Background: Use of evidence to inform health policy and planning decisions is important to ensure effective, efficient and equitable interventions, yet there has been little examination of decentralized, regional health bodies. This study aimed to examine the extent, purposes and sources of evidence used by Australian Primary Health Networks (PHNs) to inform regional primary health care planning, and explore conceptions of, and attitudes towards evidence.

Methods: We conducted document analysis of all 31 PHNs' Needs Assessments, Activity Work Plans and Annual Reports, and conducted 29 interviews with key stakeholders from a sample of five PHNs.

Addressing health equity during design and implementation of health system reform initiatives: a scoping review and framework.

Background: Health equity is a commonly asserted goal of health systems. However, there is a limited understanding on how best to promote equity as a part of health system reform initiatives. We conducted a scoping review to (1) identify and characterise strategies that promote health equity during the design and implementation of health system reform initiatives; and (2) determine opportunities to strengthen health equity informed policy design and implementation processes and outcomes.

Long-term cost-effectiveness of health behaviour intervention to manage type 2 diabetes in Nepal.

Background: Long-term cost-effectiveness analyses of health behaviour interventions to effectively manage type 2 diabetes mellitus (T2DM) in low-income countries are crucial for minimising economic burden and optimising resource allocation. Therefore, this study aimed to estimate the long-term cost-effectiveness of implementing a health behaviour intervention to manage T2DM in Nepal.

Methods: A Markov model in combination with a decision tree was developed to compare the costs and outcomes of the health behaviour intervention against usual care among 481 (238-intervention and 243-control) participants from healthcare system and societal perspectives.