915,186 results match your criteria: "Australia; The Baird Institute for Heart and Lung Surgical Research[Affiliation]"

Ravulizumab is a second-generation complement component 5 (C5) inhibitor (C5i) approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) following positive results from two pivotal trials in patients with PNH originally naive to C5i treatment and eculizumab-experienced patients with PNH. In both trials, after the 26week primary evaluation period, all patients received ravulizumab for up to 6 years. To report ravulizumab treatment outcomes in patients with PNH originally naive to C5i treatment and eculizumab-experienced patients with PNH treated for up to 6 years.

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Background: Enterotoxigenic F4 E. coli (F4-ETEC) pose an economic threat to the swine industry through reduced growth, increased mortality and morbidity, and increased costs associated with treatment. Prevention and treatment of F4-ETEC often relies on antimicrobials; however, due to the threat of antimicrobial resistance, antimicrobial use is being minimized, and hence alternative control methods are needed.

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A systematic review to determine the effect of strategies to sustain chronic disease prevention interventions in clinical and community settings.

Transl Behav Med

January 2025

School of Medicine and Public Health, The University of Newcastle, Newcastle, University Drive, Callaghan, 2308 New South Wales, Australia.

This review assessed the effect of strategies designed to sustain the delivery of evidenced based interventions (EBIs) which target behavioural risk factors linked to leading causes of chronic disease in clinical and community settings. Seven electronic databases were searched for randomised controlled studies published from earliest record to November 2022. Studies were included if they tested a strategy to sustain the delivery of an EBI within clinical or community settings.

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BCL6 coordinates muscle mass homeostasis with nutritional states.

Proc Natl Acad Sci U S A

January 2025

Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037-1002.

Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional status; however, the detailed mechanisms remain to be fully elucidated. Here, we show that the transcriptional repressor B cell lymphoma 6 (BCL6) maintains muscle mass by sustaining GH action.

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This study investigates the functional network underlying response inhibition in the human brain, particularly the role of the basal ganglia in successful action cancellation. Functional magnetic resonance imaging (fMRI) approaches have frequently used the stop-signal task to examine this network. We merge five such datasets, using a novel aggregatory method allowing the unification of raw fMRI data across sites.

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Early childhood education and care (ECEC) settings are key for improving health behaviors, including physical activity (PA) and nutrition. In 2017, the province of British Columbia (BC) implemented a provincial-level Active Play policy supported by a capacity-building intervention. Significant improvements in all PA policies and practices and the majority of nutrition policies were observed post-implementation.

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Atrial septal defect closure via a partial lower ministernotomy.

Multimed Man Cardiothorac Surg

January 2025

• Department of Cardiothoracic Surgery, Royal Children's Hospital, Melbourne, Australia • Department of Paediatrics, University of Melbourne, Melbourne, Australia • Heart Research Group, Murdoch Children's Research Institute, Melbourne, Australia.

Patients with secundum atrial septal defects preferentially undergo device closure;  however, this procedure is not always feasible. Instead, patients can safely undergo surgical closure. At a time when minimally invasive surgery can now be utilized with improved cosmetic results and the same excellent outcomes as a conventional sternotomy for an atrial septal defect closure, we propose the partial lower ministernotomy as the new standard for surgical atrial septal defect closure.

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Sonographer Experiences of Interprofessional Ultrasound Education: A Qualitative Study.

J Contin Educ Health Prof

January 2025

Ms. Cormack: Adjunct Senior Lecturer, Medical Imaging and Radiation Sciences Department, Faculty of Medicine, Nursing and Health Sciences, Monash University, and PhD Candidate, Education Portfolio, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.

Introduction: Point-of-care ultrasound (POCUS) technology has evolved rapidly and is being embraced by many health professionals as a valuable clinical tool. Sonographers are now teaching ultrasound skills to other health professionals in the clinical setting, including doctors, nurses, midwives, paramedics, and physiotherapists. The purpose of this study was to understand the breadth of the opportunities, transitions, and challenges experienced by sonographer educators navigating new interprofessional teaching roles.

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Antigen 43 associated with membrane vesicles contributes to bacterial cell association and biofilm formation.

Microbiol Spectr

January 2025

Department of Microbiology, Anatomy, Physiology, and Pharmacology, La Trobe University, Melbourne, Victoria, Australia.

Bacterial membrane vesicles (MVs) are produced by all bacteria and contribute to numerous bacterial functions due to their ability to package and transfer bacterial cargo. In doing so, MVs have been shown to facilitate horizontal gene transfer, mediate antimicrobial activity, and promote biofilm formation. Uropathogenic is a pathogenic Gram-negative organism that persists in the urinary tract of its host due to its ability to form persistent, antibiotic-resistant biofilms.

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COVID-19 impacted many men's intimate partner relationships, with distressed and disrupted partnerships consistently featured in commentaries with linkages to mental health challenges. The current study draws from interviews with 23 Canadian-based men, 19-50 years old, who experienced a break-up during COVID-19. Addressing the research question, "What are the connections between masculinities, men's mental health, and intimate partner relationship break-ups during COVID-19?", three thematic findings were derived: (1) Virtually Together and Growing Apart, (2) Mentally Trapped, and Failing Fast and Slow, and (3) Introspections and Moving On.

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Peripheral arterial chemoreceptors monitor the levels of arterial blood gases and adjust ventilation and perfusion to meet metabolic demands. These chemoreceptors are present in all vertebrates studied to date but have not been described fully in reptiles other than turtles. The goals of this study were to 1) identify functional chemosensory areas in the South American rattlesnake (Crotalus durissus) 2) determine the neurochemical content of putative chemosensory cells in these areas and 3) determine the role each area plays in ventilatory and cardiovascular control.

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Unlabelled: Stroke patients are rarely asked about their responses to specific design attributes. Virtual reality (VR) offers a promising tool to explore how hospital environments are experienced after stroke.

Purpose: To gather perspectives and emotional responses regarding physical design attributes of hospital patient rooms after stroke.

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is a free, weekly organized mass participation physical activity event providing a remarkable example of at-scale dissemination, with over 1 million participants and 150,000 volunteers in Australia. This qualitative study draws on stakeholders' experiences to explore how succeeded with its dissemination and sustainability in Australia. Maximum variation and snowball sampling methods were used to select interviewees representing three stakeholder groups: Australia employees; volunteer organizers (event directors and ambassadors); and local external stakeholders (e.

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Conjugation of PDLA onto MgO microspheres: comparison between solution grafting and melt grafting methods.

J Mater Chem B

January 2025

Engineering Research Centre for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Magnesium oxide (MgO) is known for its bioactivity and osteoconductivity when incorporated into biodegradable poly(lactic acid) (PLA), whereas the weak interfacial bonding between MgO microspheres (mMPs) and PLA often leads to suboptimal composite properties with uncontrollable functionality. Conjugation of mMPs with PLA may offer a good way to enhance their compatibility. In this study, we systematically investigated two grafting techniques, solution grafting (Sol) and melt grafting (Mel), to decorate poly (D-lactic acid) (PDLA) on mMPs pre-treated by prioritized hydration to obtain Sol MPs and Mel MPs, in order to optimize the grafting efficiency and improve their controllability in the properties including the crystal structure and surface morphology.

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Autistic people experience more mental health conditions like depression or anxiety than non-autistic people. They are also more likely to experience difficulties in accessing mental health supports Clinicians have published suggestions on how to improve therapy for autistic people. However, whether these ways to adapt (i.

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Background: Parkinson's disease (PD) is the most common neurodegenerative movement disease. Human endogenous retroviruses (HERVs) are proviral remnants of ancient retroviral infection of germ cells that now constitute about 8% of the human genome. Under certain disease conditions, HERV genes are activated and partake in the disease process.

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The sulfosugar sulfoquinovose (SQ) is catabolized through the sulfoglycolytic Entner-Doudoroff pathway, beginning with the oxidation of SQ to sulfogluconolactone by SQ dehydrogenase. We present a comprehensive structural and kinetic characterization of Pseudomonas putida SQ dehydrogenase (PpSQDH). PpSQDH is a tetrameric enzyme belonging to the short-chain dehydrogenase/reductase (SDR) superfamily with a strong preference for NAD+ over NADP+.

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Background: After-hours pediatric anesthesia may pose increased risks, with a heightened potential for sudden cardio-respiratory decline. While mortality rates are low in Australia and New Zealand, critical events and morbidity occur more frequently and present ongoing challenges. However, little is known about how trainees are supervised during these high-risk periods.

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The multifaceted role of XCL1 in health and disease.

Protein Sci

February 2025

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

The chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability to stimulate the directional migration of cells. All chemokines adopt a very similar folded structure that binds a specific G protein-coupled receptor (GPCR), and most chemokines bind extracellular matrix glycosaminoglycans, often in a dimeric or oligomeric form. Owing in part to the lack of a disulfide bond that is conserved in all other chemokines, XCL1 interconverts between two distinct structures with distinct functions.

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The existing research on sexual violence has primarily concentrated on instances where cisgender, heterosexual men have perpetrated sexual violence against cisgender, heterosexual women, with knowledge about LGBTQ+ people underdeveloped. However, there is a growing body of literature examining the experiences of LGBTQ+ people. No previous review has critically synthesized both quantitative and qualitative scholarly studies on adult LGBTQ+ sexual violence globally.

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LGBTQ+ Adult Sexual Violence Critical Scoping Review: Victimization Risk Factors.

Trauma Violence Abuse

January 2025

Criminology, School of Social and Political Sciences, The University of Melbourne, Melbourne, VIC, Australia.

Sexual violence experienced by LGBTQ+ adults is a rapidly expanding field of academic study. Therefore, there is a need for a synthesis and critical analysis of the research. The aim of this review was to conduct a critical review of the academic literature on adult LGBTQ+ sexual violence and to provide recommendations for future research.

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Metformin use and pancreatic ductal adenocarcinoma outcomes: a narrative review.

ANZ J Surg

January 2025

Department of Surgery, Western Health, St. Albans, Victoria, Australia.

Background: Metformin is a diabetes medication with anti-mitotic properties. A narrative review was performed to investigate people using metformin and the risk of developing pancreatic ductal adenocarcinoma (PDAC) as well as survival outcomes in established PDAC.

Methods: Relevant studies on metformin use and PDAC were retrieved from PubMed including observational studies on metformin and the risk of developing PDAC and survival outcomes in PDAC, and randomized controlled trials of metformin as a treatment in PDAC.

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